Role of respiratory uncoupling in drug-induced mitochondrial permeability transition

2021 ◽  
pp. 115659
Author(s):  
Tomoyuki Sato ◽  
Akinori Takemura ◽  
Kousei Ito
Keyword(s):  
Mitochondrial Permeability Transition ◽  
Permeability Transition ◽  
Drug Induced ◽  
Mitochondrial Permeability ◽  
Respiratory Uncoupling

scholarly journals Calcium preconditioning inhibits mitochondrial permeability transition and apoptosis

2001 ◽  
Vol 280 (2) ◽  
pp. H899-H908 ◽  
Author(s):  
Meifeng Xu ◽  
Yigang Wang ◽  
Kyoji Hirai ◽  
Ahmar Ayub ◽  
Muhammad Ashraf
Keyword(s):  
Mitochondrial Permeability Transition ◽  
Adenine Nucleotide ◽  
Permeability Transition ◽  
Cytochrome C Release ◽  
Mitochondrial Permeability ◽  
Lactate Dehydrogenase Release ◽  
Viable Cells ◽  
Reoxygenation Injury ◽  
Injury Protection

We tested the hypothesis whether calcium preconditioning (CPC) reduces reoxygenation injury by inhibiting mitochondrial permeability transition (MPT). Cultured myocytes were preconditioned by a brief exposure to 1.5 mM calcium (CPC) and subjected to 3 h of anoxia followed by 2 h of reoxygenation (A-R). Myocytes were also treated with 0.2 μM/l cyclosporin A (CsA), an inhibitor of MPT, before A-R. A significant increase of viable cells and reduced lactate dehydrogenase release was observed both in CPC- and CsA-treated myocytes compared with the A-R group. Cytochrome c release was predominantly observed in the cytoplasm of myocytes in the A-R group in contrast with CPC- or CsA-treated groups, where it was restricted only to mitochondria. Similarly, the cell death by apoptosis was also markedly attenuated in these groups. Electron-dense Ca2+ deposits in mitochondria were also less frequent. Atractyloside (20 μM/l), an adenine nucleotide translocase inhibitor, caused changes similar to those in the A-R group, suggesting a role of MPT in A-R injury. Protection by inhibition of MPT by CsA and CPC suggests that MPT plays an important role in reoxygenation/reperfusion injury. The data further suggest that preconditioning inhibits MPT by inhibiting Ca2+accumulation by mitochondria.

scholarly journals Xenon Preconditioning: The Role of Prosurvival Signaling, Mitochondrial Permeability Transition and Bioenergetics in Rats

2009 ◽  
Vol 108 (3) ◽  
pp. 858-866 ◽  
Author(s):  
Yasushi Mio ◽  
Yon Hee Shim ◽  
Ebony Richards ◽  
Zeljko J. Bosnjak ◽  
Paul S. Pagel ◽  
...  
Keyword(s):  
Mitochondrial Permeability Transition ◽  
Permeability Transition ◽  
Mitochondrial Permeability

Role of mitochondrial permeability transition in fetal brain damage in rats

2004 ◽  
Vol 30 (4) ◽  
pp. 247-253 ◽  
Author(s):  
Akihito Nakai ◽  
Yukino Shibazaki ◽  
Yoshinari Taniuchi ◽  
Hidehiko Miyake ◽  
Atsuko Oya ◽  
...  
Keyword(s):  
Brain Damage ◽  
Mitochondrial Permeability Transition ◽  
Fetal Brain ◽  
Permeability Transition ◽  
Mitochondrial Permeability
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