Combined biological and chemical catalysis in the preparation of oxycodone

Tetrahedron ◽  
2004 ◽  
Vol 60 (3) ◽  
pp. 561-568 ◽  
Author(s):  
Adam J Walker ◽  
Neil C Bruce
Keyword(s):  
Chemical Catalysis

Protein Flexibility Catalyzes a Cell Signaling Reaction of the Ras-GAP Complex

2019 ◽  
Author(s):  
Keiei Kumon ◽  
Masahiro Higashi ◽  
Shinji Saito ◽  
Shigehiko Hayashi
Keyword(s):  
Cell Signaling ◽  
Conformational Changes ◽  
Catalytic Reaction ◽  
Protein Complex ◽  
Enzyme Mechanism ◽  
Activation Free Energy ◽  
Chemical Catalysis ◽  
Simple Chemical ◽  
A Cell ◽  
Enzyme Molecules

Many enzyme molecules exhibit characteristic global and slow dynamics which furnish them with allostery realizing remarkable molecular functionalities more than simple chemical catalysis. However, molecular mechanism of a catalytic reaction associated with the molecular flexibility of enzymes is not well-understood. Here we report a hybrid molecular simulation study on GTPase activity of a Ras-GAP protein complex for cell signaling termination. We unveiled that extensive conformational changes of the protein complex and exclusion of internal water molecules are induced upon the transition state (TS) formation in the catalytic reaction and significantly lower the reaction activation free energy. We also revealed that tumor-related mutations perturb those conformational changes upon the TS formation, leading to reduction of the catalytic activity. The findings of the remarkably dynamic protein conformation directly linking to the catalytic reaction have broad implications for understanding of enzyme mechanism and for developments of allosteric drugs and novel catalysts.

Oxygen defects-stabilized heterogeneous single atom catalysts: preparation, property and catalytic application

2021 ◽  
Author(s):  
Lei Zhang ◽  
Xiu-Fei Zhao ◽  
Zhengqiu Yuan ◽  
Ming Wu ◽  
Hu Zhou
Keyword(s):  
Electronic Structure ◽  
Single Atom ◽  
Metal Species ◽  
Coordination Environment ◽  
Chemical Catalysis ◽  
Catalytic Application ◽  
Oxygen Defects ◽  
Catalysts Preparation

Single atom catalysts (SACs) show outstanding activity and selectivity in chemical catalysis owing to its unique electronic structure and unsaturated coordination environment, in which every dispersed metal species on support...

Cryptic functions of enzymes in chemical catalysis

1983 ◽  
Vol 114 (10) ◽  
pp. 1059-1069 ◽  
Author(s):  
A. Previero ◽  
M-A. Coletti-Previero ◽  
L. Galzigna
Keyword(s):  
Chemical Catalysis

scholarly journals Characterization of the Amino Acids fromNeisseria meningitidisMethionine Sulfoxide Reductase B Involved in the Chemical Catalysis and Substrate Specificity of the Reductase Step

2007 ◽  
Vol 282 (44) ◽  
pp. 32397-32405 ◽  
Author(s):  
Fabrice Neiers ◽  
Sanjiv Sonkaria ◽  
Alexandre Olry ◽  
Sandrine Boschi-Muller ◽  
Guy Branlant
Keyword(s):  
Amino Acids ◽  
Substrate Specificity ◽  
Chemical Catalysis

scholarly journals (2Sp,4R,6R,8Sp)-4,6-Dimethyl-1-phenyl-diferroceno-1-phosphines

Molbank ◽  
10.3390/m1098 ◽  
2019 ◽  
Vol 2019 (4) ◽  
pp. M1098 ◽  
Author(s):  
Philipp Honegger ◽  
Michael Widhalm
Keyword(s):  
Chemical Catalysis ◽  
Single Diastereomer

Ferrocene-based compounds are powerful asymmetric ligands usable for chemical catalysis. We present the synthesis of six new homochiral diferroceno cycles potentially useful as P,O-, P,N- or P,S-ligands. Due to the stereoconservative nature of the SN1 reaction at carbons adjacent to ferrocene units, we obtained a single diastereomer of the 8-membered diferroceno[c,f]heterophosphocines in all cases.

Chemical catalysis of the isomerisation of peroxidising herbicidal thiadiazolidines

1999 ◽  
Vol 55 (6) ◽  
pp. 657-658 ◽  
Author(s):  
Istvan Jablonkai ◽  
Tamas Kömives ◽  
Peter Böger ◽  
Yukiharu Sato ◽  
Ko Wakabayashi
Keyword(s):  
Chemical Catalysis
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