PAX2 expression is correlated with better survival in tamoxifen-treated breast carcinoma patients

2018 ◽  
Vol 52 ◽  
pp. 135-142 ◽  
Author(s):  
Rosa Jahangiri ◽  
Fatemeh Mosaffa ◽  
Masoumeh Gharib ◽  
Amir Nader Emami Razavi ◽  
Afshin Abdirad ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Treated Breast ◽  
Pax2 Expression

scholarly journals Bio-Field Array: The Influence of Junction Mediating and Regulatory Protein Expression on Cytoskeletal Filament Behavior During Apoptosis in Triple-Negative Breast Cancer

2019 ◽  
Vol 13 ◽  
pp. 117822341983098
Author(s):  
Marcy C Purnell
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Quantitative Polymerase Chain Reaction ◽  
Regulatory Protein ◽  
Cancer Cell Line ◽  
Treated Breast ◽  
Poor Outcomes ◽  
The Unfolded Protein Response

Introduction: The Bio-Field Array (BFA) is a device that generates a dielectrophoretic electromagnetic field (DEP-EMF) when placed in a hypotonic saline solution and a direct current (dc) of ~3 amperes is applied. Human triple-negative breast cancer (MDA-MB-231 cells) is known to have a high percentage of apoptotic ( P53) deficient cells and some patients can have poor outcomes with current treatments. Objectives: Previously, we reported a strong upregulation of the apoptotic arm of the unfolded protein response, via reverse transcription–quantitative polymerase chain reaction (RT-qPCR), as well as positive annexin staining in this human breast carcinoma, when grown in media prepared with BFA’s dc DEP-EMF treated saline. Here we will examine and discuss cytoskeletal microtubule changes that were noted in the treated breast carcinoma that are strongly suggestive of apoptosis and the possible correlation of these microtubule changes to the upregulation of Junction Mediating and Regulatory Protein ( JMY, a P53/TP53 cofactor) that is known to drive cytoskeleton microfilaments (actin) function. Methods: In addition to microarray and RT-qPCR analyses, we conducted 7 days of fluorescent microscopic analyses of tubulin assays in these treated versus control MDA-MB-231 cells. Results: These data suggest 2 possible forms of apoptosis, rounded and irregular, may be occurring and possibly facilitated by the significant upregulation (via microarray and RT-qPCR) of an important but poorly understood Nucleation-Promoting Factor (NPF), JMY. Conclusions: The ability of the BFA dc DEP-EMF to significantly upregulate JMY and possibly influence the regulation of unbranched (nucleation-microtubule spikes) and branched forms (autophagy) of actin in the cytoplasmic domains may facilitate a “two coffins” or round and irregular necrosis-like apoptosis for this highly aggressive and often apoptotic-deficient breast cancer cell line.

scholarly journals Excision of metastatic breast cancer from sternum and reconstruction in two patients with solitary metastatic spread

2020 ◽  
Vol 2020 (8) ◽  
Author(s):  
Saifullah Mohamed ◽  
Khurum Mazhar ◽  
Ahmed Osman ◽  
Akshay Patel ◽  
Lakshmi Srinivasan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Carcinoma ◽  
Previous History ◽  
Metastatic Breast ◽  
Extent Of Resection ◽  
Left Breast ◽  
Term Survival ◽  
Metastatic Breast Carcinoma ◽  
History Of ◽  
Treated Breast

Abstract Metastatic breast carcinoma is a relatively common clinical entity. However, the prognosis of oligometastatic and polygometastatic disease differs considerably pertaining to five-year survival. Metastatic breast carcinoma to the sternum has been described as early as 1988. We describe two cases in our institution who presented with solitary sternal metastases with a previous history of treated breast cancer. In both cases, there had been a history of previous left breast cancer treated aggressively with surgical resection and adjuvant oncological therapy and maintenance hormonal therapy. Partial sternectomy or total sternectomy for solitary metastatic sternal deposits is well established with relatively low morbidity and mortality and improvement in quality of life and possible improvement in long-term survival. Furthermore, reconstructive options are inherently dependent on extent of resection performed. These techniques can incorporate the use of sternal plates in order to approximate defects and reinforce the sternum in the setting of partial sternectomy.

Tamoxifen-treated breast carcinoma patients and the risk of acute myocardial infarction and newly-diagnosed angina

Cancer ◽  
2005 ◽  
Vol 103 (6) ◽  
pp. 1114-1121 ◽  
Author(s):  
Brian D. Bradbury ◽  
Timothy L. Lash ◽  
James A. Kaye ◽  
Susan S. Jick
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Breast Carcinoma ◽  
Newly Diagnosed ◽  
Treated Breast

Sentinel lymph node biopsy using periareolar injection of radiocolloid for patients with neoadjuvant chemotherapy-treated breast carcinoma

Cancer ◽  
2004 ◽  
Vol 100 (12) ◽  
pp. 2555-2561 ◽  
Author(s):  
Kenzo Shimazu ◽  
Yasuhiro Tamaki ◽  
Tetsuya Taguchi ◽  
Kenji Akazawa ◽  
Tomoo Inoue ◽  
...  
Keyword(s):  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Breast Carcinoma ◽  
Neoadjuvant Chemotherapy ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Treated Breast

HER-2/neu Assessment in Primary Chemotherapy Treated Breast Carcinoma: No Evidence of Gene Profile Changing

2003 ◽  
Vol 80 (2) ◽  
pp. 207-214 ◽  
Author(s):  
Gian Paolo Dagrada ◽  
Alessandra Mezzelani ◽  
Loredana Alasio ◽  
Mario Ruggeri ◽  
Roberta Romanò ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Primary Chemotherapy ◽  
Gene Profile ◽  
Her 2 ◽  
Treated Breast

Surveillance for uterine abnormalities in tamoxifen-treated breast carcinoma survivors

Cancer ◽  
2000 ◽  
Vol 89 (4) ◽  
pp. 800-810 ◽  
Author(s):  
Michelle D. Althuis ◽  
Mary Sexton ◽  
Patricia Langenberg ◽  
Trudy L. Bush ◽  
Katherine Tkaczuk ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Treated Breast

Breast carcinoma in children

JAMA ◽  
1966 ◽  
Vol 195 (5) ◽  
pp. 388-390 ◽  
Author(s):  
R. W. McDivitt
Keyword(s):  
Breast Carcinoma
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