Preventing excess replication origin activation to ensure genome stability

2021 ◽  
Author(s):  
Bhushan L. Thakur ◽  
Anagh Ray ◽  
Christophe E. Redon ◽  
Mirit I. Aladjem
Keyword(s):  
Replication Origin ◽  
Genome Stability ◽  
Origin Activation

scholarly journals BRPF 3‐ HBO 1 regulates replication origin activation and histone H3K14 acetylation

2015 ◽  
Vol 35 (2) ◽  
pp. 176-192 ◽  
Author(s):  
Yunpeng Feng ◽  
Arsenios Vlassis ◽  
Céline Roques ◽  
Marie‐Eve Lalonde ◽  
Cristina González‐Aguilera ◽  
...  
Keyword(s):  
Replication Origin ◽  
Origin Activation ◽  
H3k14 Acetylation

The programme of DNA replication: beyond genome duplication

2013 ◽  
Vol 41 (6) ◽  
pp. 1720-1725 ◽  
Author(s):  
Blanca Gómez-Escoda ◽  
Pei-Yun Jenny Wu
Keyword(s):  
Dna Replication ◽  
Cell Growth ◽  
Dna Synthesis ◽  
Genetic Information ◽  
Replication Origin ◽  
Genome Duplication ◽  
Replication Initiation ◽  
Origin Activation ◽  
Key Steps ◽  
Cell Growth And Proliferation

The accurate duplication and transmission of genetic information is critical for cell growth and proliferation, and this is ensured in part by the multi-layered regulation of DNA synthesis. One of the key steps in this process is the selection and activation of the sites of replication initiation, or origins, across the genome. Interestingly, origin usage changes during development and in different pathologies, suggesting an integral interplay between the establishment of replication initiation along the chromosomes and cellular function. The present review discusses how the spatiotemporal organization of replication origin activation may play crucial roles in the control of biological events.

The regulation of replication origin activation

1999 ◽  
Vol 9 (1) ◽  
pp. 62-68 ◽  
Author(s):  
Anne D Donaldson ◽  
J Julian Blow
Keyword(s):  
Replication Origin ◽  
Origin Activation

scholarly journals Subcellular Proteomics Reveals a Role for Nucleo-cytoplasmic Trafficking at the DNA Replication Origin Activation Checkpoint

2013 ◽  
Vol 12 (3) ◽  
pp. 1436-1453 ◽  
Author(s):  
Claire M. Mulvey ◽  
Slavica Tudzarova ◽  
Mark Crawford ◽  
Gareth H. Williams ◽  
Kai Stoeber ◽  
...  
Keyword(s):  
Dna Replication ◽  
Replication Origin ◽  
Origin Activation ◽  
Dna Replication Origin ◽  
Subcellular Proteomics

scholarly journals Caught in the act: structural dynamics of replication origin activation and fork progression

2020 ◽  
Vol 48 (3) ◽  
pp. 1057-1066 ◽  
Author(s):  
Jacob S. Lewis ◽  
Alessandro Costa
Keyword(s):  
Dna Replication ◽  
Structural Dynamics ◽  
Single Molecule ◽  
Single Particle ◽  
Replication Origin ◽  
Origin Activation ◽  
Recent Advances ◽  
Eukaryotic Dna ◽  
New Challenges

This review discusses recent advances in single-particle cryo-EM and single-molecule approaches used to visualise eukaryotic DNA replication reactions reconstituted in vitro. We comment on the new challenges facing structural biologists, as they turn to describing the dynamic cascade of events that lead to replication origin activation and fork progression.

scholarly journals Chromatin‐dependent and ‐independent regulation of DNA replication origin activation in budding yeast

EMBO Reports ◽  
2012 ◽  
Vol 14 (2) ◽  
pp. 191-198 ◽  
Author(s):  
Marko Lõoke ◽  
Kersti Kristjuhan ◽  
Signe Värv ◽  
Arnold Kristjuhan
Keyword(s):  
Dna Replication ◽  
Replication Origin ◽  
Budding Yeast ◽  
Origin Activation ◽  
Dna Replication Origin

scholarly journals Universal Temporal Profile of Replication Origin Activation in Eukaryotes

PLoS ONE ◽  
2009 ◽  
Vol 4 (6) ◽  
pp. e5899 ◽  
Author(s):  
Arach Goldar ◽  
Marie-Claude Marsolier-Kergoat ◽  
Olivier Hyrien
Keyword(s):  
Replication Origin ◽  
Temporal Profile ◽  
Origin Activation
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