Environmental xenobiotics and nuclear receptors—Interactions, effects and in vitro assessment

2006 ◽  
Vol 20 (1) ◽  
pp. 18-37 ◽  
Author(s):  
J. Janošek ◽  
K. Hilscherová ◽  
L. Bláha ◽  
I. Holoubek
Keyword(s):  
Nuclear Receptors ◽  
In Vitro Assessment

scholarly journals In vitro assessment of pesticides capacity to act as agonists/antagonists of the thyroid hormone nuclear receptors

iScience ◽  
2021 ◽  
Vol 24 (10) ◽  
pp. 103246
Author(s):  
Yanis Zekri ◽  
Laure Dall Agnol ◽  
Frédéric Flamant ◽  
Romain Guyot
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptors ◽  
Capacity To Act ◽  
In Vitro Assessment

scholarly journals In vitro assessment of the capacity of pesticides to act as agonists/antagonists of the thyroid hormone nuclear receptors

2020 ◽  
Author(s):  
Yanis Zekri ◽  
Laure Dall Agnol ◽  
Frédéric Flamant ◽  
Romain Guyot
Keyword(s):  
Thyroid Hormone ◽  
Nuclear Receptors ◽  
Transcriptome Analysis ◽  
Cellular Response ◽  
In Vitro Tests ◽  
Neural Cells ◽  
Hormone Signaling ◽  
Neurodevelopmental Toxicity ◽  
In Vitro Assessment

SummarySeveral in vitro tests, including transcriptome analysis of neural cells, were performed to assess the capacity of 33 pesticides to act as thyroid hormone disruptors (THD). Although some pesticides elicit a cellular response, which interferes with thyroid hormone signaling, we found no evidence that they can act as receptor agonists or antagonists. We conclude that the nuclear receptors of thyroid hormone are not common targets of THD, and that pesticide neurodevelopmental toxicity is not explained by a general alteration of neural cell response to thyroid hormone.

In vitro assessment of Labisia pumila and its constituents for interactions with CYPs, P-GP and PXR

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
VK Manda ◽  
OR Dale ◽  
C Awortwe ◽  
Z Ali ◽  
IA Khan ◽  
...  
Keyword(s):  
In Vitro Assessment ◽  
Labisia Pumila
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