Differential mutagenic response of Salmonella typhimurium to the plant-metabolized organophosphorus insecticides, phoxim and azinphos methyl

2007 ◽  
Vol 21 (5) ◽  
pp. 950-955 ◽  
Author(s):  
Sandra Gómez-Arroyo ◽  
Josefina Cortés-Eslava ◽  
Rafael Villalobos-Pietrini ◽  
María Elena Calderón-Segura ◽  
Ana Rosa Flores-Márquez ◽  
...  
Keyword(s):  
Salmonella Typhimurium ◽  
Organophosphorus Insecticides ◽  
Azinphos Methyl ◽  
Mutagenic Response

The role of plant metabolism in the mutagenic and cytotoxic effects of four organophosphorus insecticides in Salmonella typhimurium and in human cell lines

Chemosphere ◽  
2013 ◽  
Vol 92 (9) ◽  
pp. 1117-1125 ◽  
Author(s):  
Josefina Cortés-Eslava ◽  
Sandra Gómez-Arroyo ◽  
Francisco Arenas-Huertero ◽  
Saúl Flores-Maya ◽  
Martha E. Díaz-Hernández ◽  
...  
Keyword(s):  
Salmonella Typhimurium ◽  
Cell Lines ◽  
Human Cell ◽  
Plant Metabolism ◽  
Human Cell Lines ◽  
Organophosphorus Insecticides ◽  
Cytotoxic Effects

Metabolic Activation and Inactivation of Metanil Yellow and Orange II in the Salmonella typhimurium his− Reversion Assay

1996 ◽  
Vol 59 (3) ◽  
pp. 244-248 ◽  
Author(s):  
P. B. RASTOGI ◽  
R. E. LEVIN
Keyword(s):  
Salmonella Typhimurium ◽  
Rat Liver ◽  
Metabolic Activation ◽  
Flavin Mononucleotide ◽  
Orange Ii ◽  
Combined Use ◽  
Mutagenic Response ◽  
Experimental Protocols ◽  
Metanil Yellow ◽  
S9 Fraction

Among a variety of experimental protocols used, the combined use of 0.5% dextrose in bottom agar and 1 μmol of flavin mononucleotide (FMN) in preincubation mixtures without fraction S9 mix resulted in the highest level of induced Salmonella typhimurium his− reversions with both dyes metanil yellow and orange II with strain TA100. Strain TA98 yielded notably lower levels of reversions under the same conditions. The presence of uninduced hamster liver S9 fraction resulted in a weak mutagenic response while Aroclor 1254-induced rat liver S9 fraction resulted in the complete absence of mutagenicity with both strains and with both dyes.

Tolerance of Aphytis melinus DeBach (Hymenoptera: Aphelinidae) to 20 orchard chemical treatments in relation to integrated control of red scale, Aonidiella aurantii (Maskell) (Homoptera: Diaspididae)

1977 ◽  
Vol 17 (85) ◽  
pp. 323 ◽  
Author(s):  
RAH Davies ◽  
IW McLaren
Keyword(s):  
Bordeaux Mixture ◽  
Integrated Control ◽  
Insect Growth Regulator ◽  
Nonyl Phenol ◽  
Organophosphorus Insecticides ◽  
Aphytis Melinus ◽  
Chemical Treatments ◽  
Citrus Groves ◽  
Azinphos Methyl ◽  
Spray Distribution

The toxicity of 20 orchard chemicals at field rates was determined for all stages of Aphytis melinus in the laboratory. The insecticides Bacillus thuringiensis + surfactant, endosulfan, pirimicarb: the miticide cyclosulfyne : the herbicides and plant growth regulators dimazide, diuron, gibberellic acid: the fungicide copper oxychloride: the nutrient mixture zinc oxide, manganese sulphate and urea : and the surfactant nonyl phenol ethoxylate (9 Eto) appear safe for use in citrus groves containing A. melinus. The herbicide dalapon + surfactant and the fungicide Bordeaux mixture were moderately toxic to immatures, and the herbicide bromacil was moderately toxic to adults. However, it is considered that careful application of these treatments is safe. The organophosphorus insecticides azinphos-methyl, maldison and parathion; the insect growth regulator hydroprene; and the miticide cyhexatin were highly toxic to either juvenile or adult stages. White oil, recommended for integration with A. melinus, was highly toxic to immature stages. This anomalous result is discussed in terms of spray distribution and integrated control of red scale on citrus

Studies of the mutagenic response of salmonella typhimurium TA98 to size-fractionated air particles: Comparison of the fluctuation and plate incorporation tests

1982 ◽  
Vol 4 (5) ◽  
pp. 531-541 ◽  
Author(s):  
W. G. Sorenson ◽  
Wen-Zong Whong ◽  
Janet P. Simpson ◽  
Frank J. Hearl ◽  
Tong-Man Ong
Keyword(s):  
Salmonella Typhimurium ◽  
Mutagenic Response

Mutagenicity of Bisbenzimidazole Derivatives

2010 ◽  
Vol 65 (1-2) ◽  
pp. 10-14 ◽  
Author(s):  
Filiz Susuz Alanyalı ◽  
Merve Arıcı ◽  
Öge Artagan ◽  
İlhan Işıkdağ ◽  
Yusuf Özkay
Keyword(s):  
Salmonella Typhimurium ◽  
Base Pair ◽  
Frameshift Mutation ◽  
Metabolic Activation ◽  
Mutagenic Response ◽  
Base Pair Substitution ◽  
Incorporation Assay ◽  
Substitution Mutation

The mutagenicities of 2,2’-(di-3-hydroxyphenyl)-1H,1H’-[5,5’]-bisbenzimidazole, 2,2’-(di- 4-hy droxyphenyl)-1H,1H’-[5,5’]-bisbenzimidazole, 2,2’-(di-3-methoxyphenyl)-1H,1H’-[5,5’]- bisbenzimidazole, 2,2’-bis-(4-nitrophenyl)-1H,1H’-[5,5’]-bisbenzimidazole, 2,2’-bis-(3-nitrophenyl)- 1H,1H’-[5,5’]-bisbenzimidazole, 2,2’-bis-(4-methylphenyl)-1H,1H’-[5,5’]-bisbenzimidazole, 2,2’-(di-4-methoxyphenyl)-1H,1H’-[5,5’]-bisbenzimidazole, and 2,2’-bis-(3-me thylphenyl)- 1H,1H’-[5,5’]-bisbenzimidazole were studied in vitro using two strains of Salmonella typhimurium with frameshift mutation (TA98) and base-pair substitution mutation (TA100) as the plate incorporation assay in the absence of metabolic activation. These compounds are currently used to treat cancer. 4-Nitrophenyl and 3-nitrophenyl compounds were found to be mutagenic on both strains of Salmonella. A clear mutagenic response was seen in nitro-bound derivatives. The mutagenic response in Salmonella test strains (TA98, TA100) and structures of molecules suggest that nitro-bound molecules could be mutagenic.

scholarly journals Mutagenic activity of airborne particulate matter from the urban area of Porto Alegre, Brazil

1998 ◽  
Vol 21 (2) ◽  
pp. 247-253 ◽  
Author(s):  
Vera Maria Ferrão Vargas ◽  
Rubem Cesar Horn ◽  
Régis Rolim Guidobono ◽  
Ana Beatriz Mittelstaedt ◽  
Irascema Girardi de Azevedo
Keyword(s):  
Particulate Matter ◽  
Salmonella Typhimurium ◽  
Urban Area ◽  
Mutagenic Activity ◽  
Airborne Particulate Matter ◽  
Metabolic Activation ◽  
Polar Fraction ◽  
Airborne Particulate ◽  
Porto Alegre ◽  
Mutagenic Response

The mutagenic activity of airborne particulate matter collected from three different sites within the urban area of Porto Alegre, Brazil, was investigated using a Salmonella/microsome assay. Samples were extracted by sonication, sequentially, with cyclohexane (CX), and dichloromethane (DCM), for a rough fractionation by polarity. The different fractions were tested for mutagenicity using Salmonella typhimurium strains TA98, with and without metabolic activation (S9 mix fraction), and TA98NR and TA98/1,8-DNP6, without metabolic activation. Mutagenic response was observed for frameshift strain TA98 in assays with and without metabolization for two sites (sites 2 and 3), which had considerable risk of environmental contamination by nonpolar (CX) and/or moderately polar (DCM) compounds. However, the values of revertants/m3 (rev/m3) were highest on the site subject to automobile exhaust (site 3) in assays without (9.56 rev/m3) and with metabolization (5.08 rev/m3). Maximum mutagenic activity was detected in the moderately polar fraction, decreasing after metabolization. Nevertheless, the nonpolar fractions (CX) gave higher mutagenic activity in the presence of metabolization than in the absence of the S9 mix fraction. The responses observed for TA98NR and TA98/1,8-DNP6 strains suggest the activity of nitrocompounds.

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