A novel synergistic anticancer effect of fungal cholestanol glucoside and paclitaxel: Apoptosis induced by an intrinsic pathway through ROS generation in cervical cancer cell line (HeLa)

2021 ◽  
pp. 105079
Author(s):  
Subramaniam Yogeswari ◽  
Subban Kamalraj ◽  
Chelliah Jayabaskaran
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Ros Generation ◽  
Cervical Cancer Cell Line ◽  
Intrinsic Pathway ◽  
Anticancer Effect ◽  
Cell Line Hela ◽  
Line Hela

scholarly journals The restraining effect of baicalein and U0126 on human cervical cancer cell line HeLa

2017 ◽  
Vol 16 (1) ◽  
pp. 957-963 ◽  
Author(s):  
Haiqiong Ye ◽  
Yujiao Zhang ◽  
Yongzhou Wang ◽  
Jiyi Xia ◽  
Xiguang Mao ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell ◽  
Cervical Cancer Cell Line ◽  
Cell Line Hela ◽  
Human Cervical Cancer Cell ◽  
Line Hela ◽  
Human Cervical Cancer

scholarly journals Caspase-mediated apoptotic effects of Ebenus boissieri barbey extracts on human cervical cancer cell line hela

2017 ◽  
Vol 13 (50) ◽  
pp. 254 ◽  
Author(s):  
Ece Simsek ◽  
Nilufer Imir ◽  
EsraArslan Aydemir ◽  
RamazanSuleyman Gokturk ◽  
Erdem Yesilada ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell Line ◽  
Cell Line Hela ◽  
Human Cervical Cancer Cell ◽  
Apoptotic Effects ◽  
Line Hela ◽  
Human Cervical Cancer

Fucoxanthin induces apoptosis in human cervical cancer cell line HeLa via PI3K/Akt pathway

Tumor Biology ◽  
2014 ◽  
Vol 35 (11) ◽  
pp. 11261-11267 ◽  
Author(s):  
Guoliu Ye ◽  
Qin Lu ◽  
Weidong Zhao ◽  
Danli Du ◽  
Lijie Jin ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Akt Pathway ◽  
Cervical Cancer Cell Line ◽  
Cell Line Hela ◽  
Human Cervical Cancer Cell ◽  
Line Hela ◽  
Human Cervical Cancer

scholarly journals The effect of Chaihu-shugan-san on cytotoxicity induction and PDGF gene expression in cervical cancer cell line HeLa in the presence of paclitaxel +cisplatin

2021 ◽  
Vol 67 (3) ◽  
pp. 143-147
Author(s):  
Xue Jianfang ◽  
Zhu Ling ◽  
Jiao Yanan ◽  
Guan Yanliang
Keyword(s):  
Gene Expression ◽  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell ◽  
Cervical Cancer Cell Line ◽  
Cell Line Hela ◽  
Significant Difference ◽  
Line Hela

Chaihu-shugan-san, as a traditional Chinese herbal formula, is composed of seven different herbs. This medicine can treat cancer due to its antioxidant compounds. In this study, the effect of Chaihu-shugan-san was considered on cytotoxicity induction and PDGF gene expression in cervical cancer cell line HeLa at different concentrations and at different times, by the MTT method. Paclitaxel + cisplatin were used as a control in this study. The expression of the PDGF gene was quantitatively evaluated in treated cells by real-time PCR, and a generalized linear model was used to evaluate the effect of the medicine, and Duncan's multiple range tests were used to evaluate the data. The results of the MTT test showed that Chaihu-shugan-san had antitumor properties in different concentrations, but there was a significant difference between this medicine and paclitaxel +cisplatin. Also, examination of gene expression showed that this medicine reduced the expression of the PDGF gene in the HeLa cancer cell line (P ? 0.04). Therefore, Chaihu-shugan-san could be suggested as an effective factor in preventing the growth of cervical cancer cells and controlling angiogenic factors that play an important role in the metastasis of cancerous tumors.

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