Involvement of activating ERK1/2 through G protein coupled receptor 30 and estrogen receptor α/β in low doses of bisphenol A promoting growth of Sertoli TM4 cells

2014 ◽  
Vol 226 (1) ◽  
pp. 81-89 ◽  
Author(s):  
Li-Chen Ge ◽  
Zhuo-Jia Chen ◽  
Han-Yan Liu ◽  
Kun-Shui Zhang ◽  
Hao Liu ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Bisphenol A ◽  
G Protein ◽  
Estrogen Receptor Α ◽  
Low Doses ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Effects of Atrazine on Estrogen Receptor α – and G Protein–Coupled Receptor 30–Mediated Signaling and Proliferation in Cancer Cells and Cancer-Associated Fibroblasts

2015 ◽  
Vol 123 (5) ◽  
pp. 493-499 ◽  
Author(s):  
Lidia Albanito ◽  
Rosamaria Lappano ◽  
Antonio Madeo ◽  
Adele Chimento ◽  
Eric R. Prossnitz ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Cancer Cells ◽  
G Protein ◽  
Estrogen Receptor Α ◽  
Cancer Associated Fibroblasts ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Low Doses of Bisphenol A Promote Human Seminoma Cell Proliferation by Activating PKA and PKG via a Membrane G-Protein–Coupled Estrogen Receptor

2009 ◽  
Vol 117 (7) ◽  
pp. 1053-1058 ◽  
Author(s):  
Adil Bouskine ◽  
Marielle Nebout ◽  
Françoise Brücker-Davis ◽  
Mohamed Benahmed ◽  
Patrick Fenichel
Keyword(s):  
Cell Proliferation ◽  
Estrogen Receptor ◽  
Bisphenol A ◽  
G Protein ◽  
Low Doses ◽  
G Protein Coupled

scholarly journals Expression of G Protein-Coupled Receptor-30, a G Protein-Coupled Membrane Estrogen Receptor, in Oxytocin Neurons of the Rat Paraventricular and Supraoptic Nuclei

Endocrinology ◽  
2007 ◽  
Vol 148 (12) ◽  
pp. 5842-5850 ◽  
Author(s):  
Hirotaka Sakamoto ◽  
Ken-ichi Matsuda ◽  
Koji Hosokawa ◽  
Mayumi Nishi ◽  
John F. Morris ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Estrogen Receptor Α ◽  
G Protein Coupled Receptor ◽  
Protein Levels ◽  
Intracellular Organelles ◽  
Nuclear Estrogen Receptor ◽  
Vasopressin Neurons ◽  
G Protein Coupled ◽  
Supraoptic Nuclei

The regulatory actions of estrogens on magnocellular oxytocin (OT) neurons of the paraventricular and supraoptic nuclei are well documented. Although the expression and distribution of nuclear estrogen receptor-β, but not estrogen receptor-α, in the OT neuron has been described, the nuclear receptors may not explain all aspects of estrogen function in the hypothalamic OT neuron. Recently a G protein-coupled receptor (GPR) for estrogens, GPR30, has been identified as a membrane-localized estrogen receptor in several cancer cell lines. In this study, we therefore investigated the expression and localization of GPR30 in magnocellular OT neurons to understand the mode of rapid estrogen actions within these neurons. Here we show that, in the paraventricular nucleus and supraoptic nucleus, GPR30 is expressed in magnocellular OT neurons at both mRNA and protein levels but is not expressed in vasopressin neurons. Specific markers for intracellular organelles and immunoelectron microscopy revealed that GPR30 was localized mainly in the Golgi apparatus of the neurons but could not be detected at the cell surface. In addition, the expression of GPR30 is also detected in the neurohypophysis. These results suggest that GPR30 may serve primarily as a nongenomic transducer of estrogen actions in the hypothalamo-neurohypophyseal system.

scholarly journals G Protein-Coupled Receptor 30 Expression Is Up-Regulated by EGF and TGFα in Estrogen Receptor α-Positive Cancer Cells

2009 ◽  
Vol 23 (11) ◽  
pp. 1815-1826 ◽  
Author(s):  
Adele Vivacqua ◽  
Rosamaria Lappano ◽  
Paola De Marco ◽  
Diego Sisci ◽  
Saveria Aquila ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Cancer Cells ◽  
G Protein ◽  
Estrogen Receptor Α ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Retracted: G-Protein–Coupled Receptor 30 and Estrogen Receptor-α Are Involved in the Proliferative Effects Induced by Atrazine in Ovarian Cancer Cells

2008 ◽  
Vol 116 (12) ◽  
pp. 1648-1655 ◽  
Author(s):  
Lidia Albanito ◽  
Rosamaria Lappano ◽  
Antonio Madeo ◽  
Adele Chimento ◽  
Eric R. Prossnitz ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
G Protein ◽  
Estrogen Receptor Α ◽  
Ovarian Cancer Cells ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled
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