The Human Equivalent Concentration: A valid approach in extrapolating animal data to the human situation

2016 ◽  
Vol 258 ◽  
pp. S38
Author(s):  
Adriana Oller
Keyword(s):  
Equivalent Concentration ◽  
Human Situation ◽  
Animal Data

Nicotine Workshop

1976 ◽  
Vol 8 (5) ◽  
Author(s):  
xxx
Keyword(s):  
Present State ◽  
Analytical Methods ◽  
Body Fluids ◽  
Advisory Board ◽  
Tobacco Company ◽  
Human Situation ◽  
Tobacco Alkaloids ◽  
Related Compounds ◽  
State Of Art

AbstractA workshop on problems related to the analysis of nicotine and nicotine metabolites in body fluids at levels pertinent to the human situation was held in November 1974 in Stockholm. It was organized by C. Enzell, B. Holmstedt and A. Pilotti at the request of the Medical Advisory Board of the Swedish Tobacco Company. The goal of the workshop was to summarize the present state of art in the area outlined by the organizers and to discuss critically the advantages and limitations of the different analytical methods available today. EIeven experts in the field of metabolism, detection and biosynthesis of nicotine and related compounds were therefore invited to present papers on these topics and to participate in the discussions. AIl speakers invited were able to attend and the papers were arranged in the following groups:Each speaker had one hour and a half at his disposal which included the discussion which, due to the informal atmosphere and the smaII number of participants, was very lively and fruitful. The papers read at this workshop comprise a very valuable coverage of recent research in the fields of metabolism of nicotine and minor tobacco alkaloids, and of the various methods available for detection of these alkaloids. The abstracts are given below, while full papers, now edited by A. Pilotti, can be obtained on request from C. Enzell of the Swedish Tobacco Company

Human Stress Recovery during Exposure to Geranium Visual Stimuli

HortScience ◽  
1998 ◽  
Vol 33 (3) ◽  
pp. 505b-505 ◽  
Author(s):  
Eunhee Kim ◽  
Richard H. Mattson
Keyword(s):  
Recovery Period ◽  
Visual Stimuli ◽  
Stress Recovery ◽  
Emotional States ◽  
Finger Skin Temperature ◽  
Physiological Indicators ◽  
Treatment Groups ◽  
Human Situation ◽  
Human Stress ◽  
Finger Skin

Evaluating human psychophysiological responses to plant visual stimuli provides a clearer understanding of factors within plant environments that enhance or maximize recovery from stress. Advances in physiological monitoring technology allow continuous recording and more-refined data collection of human responses to environmental stimuli. The objective of this study was to compare effects on stress recovery by exposures to geranium visual stimuli following an induced stressor, by measuring changes in physiological indicators and emotional states. One-hundred-fifty college students were randomly assigned to one of three treatment groups: red-flowering geraniums, non-flowering geraniums, or no geraniums. Each student viewed a 10-min film of a stressful human situation following a 5-min baseline, then was exposed to an assigned treatment setting during a 5-min recovery period. Continuous physiological measurements were taken of brainwave activities (EEG), skin conductance (EDR), and finger skin temperature. Self-rating scores of subjects' feelings were taken using the Zuckerman Inventory of Personal Reactions. Comparisons among treatment groups will be discussed based on gender and other demographic factors.

scholarly journals Animal, Body, Data: Starling Murmurations and the Dynamic of Becoming In-formation

2021 ◽  
pp. 1357034X2199284
Author(s):  
Mickey Vallee
Keyword(s):  
Data Modelling ◽  
Animal Body ◽  
Topological Relationships ◽  
Animal Populations ◽  
Animal Data ◽  
Natural Scientists ◽  
The Relationship ◽  
Affective Relations

The aim of this article is to demonstrate that data modelling is becoming a crucial, if not dominant, vector for our understanding of animal populations and is consequential for how we study the affective relations between individual bodies and the communities to which they belong. It takes up the relationship between animal, body and data, following the datafication of starling murmurations, to explore the topological relationships between nature, culture and science. The case study thus embodies a data journey, invoking the tactics claimed by social or natural scientists, who generated recent discoveries in starling murmurations, including their topological expansions and contractions. The article concludes with thoughts and suggestions for further research on animal/data entanglement, and threads the concept of databodiment throughout, as a necessary dynamic for the formation and maintenance of communities.

scholarly journals Irreversible Electroporation (IRE) in Locally Advanced Pancreatic Cancer: A Review of Current Clinical Outcomes, Mechanism of Action and Opportunities for Synergistic Therapy

2021 ◽  
Vol 10 (8) ◽  
pp. 1609
Author(s):  
Zainab L. Rai ◽  
Roger Feakins ◽  
Laura J. Pallett ◽  
Derek Manas ◽  
Brian R. Davidson
Keyword(s):  
Pancreatic Cancer ◽  
Mechanism Of Action ◽  
Locally Advanced ◽  
Irreversible Electroporation ◽  
Advanced Pancreatic Cancer ◽  
Standard Of Care ◽  
Locally Advanced Pancreatic Cancer ◽  
Animal Data ◽  
Standard Of Care Treatment ◽  
Apoptosis And Necrosis

Locally advanced pancreatic cancer (LAPC) accounts for 30% of patients with pancreatic cancer. Irreversible electroporation (IRE) is a novel cancer treatment that may improve survival and quality of life in LAPC. This narrative review will provide a perspective on the clinical experience of pancreas IRE therapy, explore the evidence for the mode of action, assess treatment complications, and propose strategies for augmenting IRE response. A systematic search was performed using PubMed regarding the clinical use and safety profile of IRE on pancreatic cancer, post-IRE sequential histological changes, associated immune response, and synergistic therapies. Animal data demonstrate that IRE induces both apoptosis and necrosis followed by fibrosis. Major complications may result from IRE; procedure related mortality is up to 2%, with an average morbidity as high as 36%. Nevertheless, prospective and retrospective studies suggest that IRE treatment may increase median overall survival of LAPC to as much as 30 months and provide preliminary data justifying the well-designed trials currently underway, comparing IRE to the standard of care treatment. The mechanism of action of IRE remains unknown, and there is a lack of data on treatment variables and efficiency in humans. There is emerging data suggesting that IRE can be augmented with synergistic therapies such as immunotherapy.

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