scholarly journals Toxicogenomic study in rat thymus of F1 generation offspring following maternal exposure to silver ion

2015 ◽  
Vol 2 ◽  
pp. 341-350 ◽  
Author(s):  
Xiugong Gao ◽  
Jeffrey J. Yourick ◽  
Vanessa D. Topping ◽  
Thomas Black ◽  
Nicholas Olejnik ◽  
...  
Keyword(s):  
Maternal Exposure ◽  
Silver Ion ◽  
F1 Generation ◽  
Generation Offspring

Effects of Maternal Exposure to Imazalil on Behavioral Development in F1-Generation Mice

2013 ◽  
Vol 98 (4) ◽  
pp. 334-342 ◽  
Author(s):  
Toyohito Tanaka ◽  
Akio Ogata ◽  
Akiko Inomata ◽  
Dai Nakae
Keyword(s):  
Behavioral Development ◽  
Maternal Exposure ◽  
F1 Generation

scholarly journals Cadmium Enhances Locomotor Behaviour in F1 Generation Mice Following Maternal Exposure During Lactation: Modulation by Quercetin

2017 ◽  
Vol 03 (01) ◽  
Author(s):  
Sumita Halder ◽  
Rajarshi Kar ◽  
Nilesh Chandra ◽  
Swapan K Bhattacharya ◽  
Pramod K Mediratta ◽  
...  
Keyword(s):  
Maternal Exposure ◽  
Locomotor Behaviour ◽  
F1 Generation

Reproductive and neurobehavioral effects of maternal exposure to ethiprole in F1-generation mice

2017 ◽  
Vol 110 (3) ◽  
pp. 259-275 ◽  
Author(s):  
Toyohito Tanaka ◽  
Toshinari Suzuki ◽  
Akiko Inomata
Keyword(s):  
Maternal Exposure ◽  
Neurobehavioral Effects ◽  
F1 Generation

The effect of maternal exposure to flaxseed on spermatogenesis in F1 generation rats

2000 ◽  
Vol 38 (4) ◽  
pp. 325-334 ◽  
Author(s):  
R.L. Sprando ◽  
T.F.X. Collins ◽  
T.N. Black ◽  
N. Olejnik ◽  
J.I. Rorie ◽  
...  
Keyword(s):  
Maternal Exposure ◽  
F1 Generation

scholarly journals Epi-mutations for spermatogenic defects by maternal exposure to Di (2-ethylhexyl) phthalate

2021 ◽  
Author(s):  
Yukiko Tando ◽  
Hitoshi Hiura ◽  
Asuka Takehara ◽  
Yumi Ito-Matsuoka ◽  
Takahiro Arima ◽  
...  
Keyword(s):  
Germ Cells ◽  
Maternal Exposure ◽  
Gene Promoters ◽  
Reporter Assay ◽  
Dna Hypermethylation ◽  
Testicular Cells ◽  
Successive Generations ◽  
Ethylhexyl Phthalate ◽  
Dehp Exposure ◽  
F1 Generation

Exposure to environmental factors during fetal development may lead to epigenomic modifications in fetal germ cells, altering gene expression and promoting diseases in successive generations. In mouse, maternal exposure to Di (2-ethylhexyl) phthalate (DEHP) is known to induce defects in spermatogenesis in successive generations, but the mechanism(s) of impaired spermatogenesis are unclear. Here, we showed that maternal DEHP exposure results in DNA hypermethylation of promoters of spermatogenesis-related genes in fetal testicular germ cells in F1 mice, and hypermethylation of Hist1h2ba, Sycp1 and Taf7l, which are crucial for spermatogenesis, persisted from fetal testicular cells to adult spermatogonia, resulting in the downregulation of expression of these genes. Forced methylation of these gene promoters silenced expression of these loci in a reporter assay. Expression and methylation of those genes tended to be downregulated and increased, respectively in F2 spermatogonia following maternal DEHP exposure. These results suggested that DEHP induced hypermethylation of Hist1h2ba, Sycp1 and Taf7l in fetal germ cells results in downregulation of these genes in spermatogonia and subsequent defects in spermatogenesis, at least in the F1 generation.

scholarly journals Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Yukiko Tando ◽  
Hitoshi Hiura ◽  
Asuka Takehara ◽  
Yumi Ito-Matsuoka ◽  
Takahiro Arima ◽  
...  
Keyword(s):  
Germ Cells ◽  
Maternal Exposure ◽  
Gene Promoters ◽  
Reporter Assay ◽  
Dna Hypermethylation ◽  
Testicular Cells ◽  
Successive Generations ◽  
Ethylhexyl Phthalate ◽  
Dehp Exposure ◽  
F1 Generation

Exposure to environmental factors during fetal development may lead to epigenomic modifications in fetal germ cells, altering gene expression and promoting diseases in successive generations. In mouse, maternal exposure to di(2-ethylhexyl) phthalate (DEHP) is known to induce defects in spermatogenesis in successive generations, but the mechanism(s) of impaired spermatogenesis are unclear. Here, we showed that maternal DEHP exposure results in DNA hypermethylation of promoters of spermatogenesis-related genes in fetal testicular germ cells in F1 mice, and hypermethylation of Hist1h2ba, Sycp1, and Taf7l, which are crucial for spermatogenesis, persisted from fetal testicular cells to adult spermatogonia, resulting in the downregulation of expression of these genes. Forced methylation of these gene promoters silenced expression of these loci in a reporter assay. These results suggested that maternal DEHP exposure-induced hypermethylation of Hist1h2ba, Sycp1, and Taf7l results in downregulation of these genes in spermatogonia and subsequent defects in spermatogenesis, at least in the F1 generation.

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