Impact of switching to a heat-not-burn tobacco product on CYP1A2 activity

Abstract Background Polytobacco product use is increasingly popular, but little is known about the prevalence, trend, and factors of such use particularly in non-western countries. Method A representative sample of 1139 current cigarette smokers aged 15+ (84.1% male) were telephone interviewed in Tobacco Control Policy-related Surveys in 2015–2017. Information collected included poly-tobacco use (PTU), smoking and socio-demographic characteristics. Associations of current PTU with related factors were analyzed using logistic regression with adjustment for confounders. Prevalence was weighted by age and sex of current cigarette users in the general population. Results Eighty-four point one percent (95% CI 81.4–86.6%) were exclusive cigarette smokers. Fifteen point nine percent (13.4–18.6%) were current polytobacco product users, 12.3% (10.2–14.8%) used one tobacco product and 2.52% (1.59–3.97%) used two tobacco products in addition to cigarette. Cigarette use with cigar was more common (6.28%, 4.75–8.27%), and the least used product with cigarette was e-cigarette (1.05%, 0.44–2.50%). The changes in overall prevalence of PTU by number of products use varied in 3 years. Current PTU was associated with being male (AOR 2.01, 95% CI 1.12–3.61), younger age (AORs range from 1.34–4.65, P for trend < .001) and less ready to quit (2.08, 1.09–3.97). Conclusions Prevalence of PTU increased slowly by year, one tobacco product use with cigarette was more common. The most used tobacco product with cigarette was cigar. Being male, younger and less ready to quit were associated with current PTU.

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Effects of conventional and heated tobacco product smoking on discoloration of artificial denture teeth

Journal of Prosthetic Dentistry ◽

10.1016/j.prosdent.2020.05.031 ◽

2021 ◽

Author(s):

Yuankun Wang ◽

Ri Ryu ◽

Jae-Min Seo ◽

Jung-Jin Lee

Keyword(s):

Tobacco Product ◽

Denture Teeth

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Dissolution Testing of Nicotine Release from OTDN Pouches: Product Characterization and Product-to-Product Comparison

Separations ◽

10.3390/separations8010007 ◽

2021 ◽

Vol 8 (1) ◽

pp. 7

Author(s):

Fadi Aldeek ◽

Nicholas McCutcheon ◽

Cameron Smith ◽

John H. Miller ◽

Timothy L. Danielson

Keyword(s):

In Vitro Release ◽

Product Category ◽

Immediate Release ◽

Tobacco Product ◽

Oral Dosage ◽

Dissolution Testing ◽

Release Rates ◽

Usp 4 ◽

Release Profiles

In recent years, oral tobacco-derived nicotine (OTDN) pouches have emerged as a new oral tobacco product category. They are available in a variety of flavors and do not contain cut or ground tobacco leaf. The on!® nicotine pouches fall within this category of OTDN products and are currently marketed in seven (7) flavors with five (5) different nicotine levels. Evaluation of the nicotine release from these products is valuable for product assessment and product-to-product comparisons. In this work, we characterized the in vitro release profiles of nicotine from the 35 varieties of on!® nicotine pouches using a fit-for-purpose dissolution method, employing the U.S. Pharmacopeia flow-through cell dissolution apparatus 4 (USP-4). The nicotine release profiles were compared using the FDA’s Guidance for Industry: Dissolution Testing of Immediate Release Solid Oral Dosage Forms. The cumulative release profiles of nicotine show a dose dependent response for all nicotine levels. The on!® nicotine pouches exhibit equivalent percent nicotine release rates for each flavor variant across all nicotine levels. Furthermore, the nicotine release profiles from on!® nicotine pouches were compared to a variety of other commercially available OTDN pouches and traditional pouched smokeless tobacco products. The percent nicotine release rates were found to be dependent on the product characteristics, showing similarities and differences in the nicotine release profiles between the on!® nicotine pouches and other compared products.

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Mahalanobis Distance Based Similarity Regression Learning of NIRS for Quality Assurance of Tobacco Product with Different Variable Selection Methods

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy ◽

10.1016/j.saa.2020.119364 ◽

2020 ◽

pp. 119364

Author(s):

Juan Huo ◽

Yuping Ma ◽

Huaiqi Li ◽

Changtong Lu ◽

Chenggang Li ◽

...

Keyword(s):

Quality Assurance ◽

Variable Selection ◽

Mahalanobis Distance ◽

Tobacco Product ◽

Selection Methods ◽

Regression Learning

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Geographic isolation predicts tobacco product use among youth: A latent class analysis

The Journal of Rural Health ◽

10.1111/jrh.12583 ◽

2021 ◽

Author(s):

Melissa D. Blank ◽

Jenny E. Ozga ◽

Katelyn F. Romm ◽

Ashley Douglas ◽

Linda Alexander ◽

...

Keyword(s):

Latent Class Analysis ◽

Latent Class ◽

Tobacco Product ◽

Class Analysis ◽

Geographic Isolation ◽

Product Use

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Adverse Childhood Experiences and Prevalence of Cigarette and E-Cigarette Use Among Adolescents in Bangkok, Thailand

Asia Pacific Journal of Public Health ◽

10.1177/1010539520962956 ◽

2020 ◽

Vol 32 (8) ◽

pp. 398-405

Author(s):

Takuma Ofuchi ◽

Aye Myat Myat Zaw ◽

Bang-on Thepthien

Keyword(s):

Adverse Childhood Experiences ◽

Multinomial Logistic Regression ◽

Tobacco Product ◽

Dual Use ◽

Childhood Experiences ◽

Adverse Childhood ◽

Different Types ◽

History Of ◽

The Relationship ◽

Score Range

Currently, e-cigarettes are the most popular tobacco product among adolescents. The purpose of this study was to explore the relationship between exposure to adverse childhood experiences (ACEs) and use of cigarettes, e-cigarettes, and dual use in a sample of adolescents in Bangkok, Thailand. The sample comprises 6167 students from 48 schools (grades 9, 11, and vocational year 2) who participated in the 2019 round of the Behavior Surveillance Survey. History of 11 ACEs was used to calculate a cumulative ACE score (range 0-11). Multinomial logistic regression was used to assess the relationship between history of ACEs and smoking. In the sample, 7.0% reported using e-cigarettes only and 9.5% used e-cigarettes and cigarettes (dual use). After controlling for sociodemographic characteristics, history of ACEs was associated with increased odds of dual use. The odds of cigarette, e-cigarette, and dual use was significantly greater if the adolescent had a history of ≥4 ACEs. Special attention is needed to prevent smoking of different types among those with a history of ACEs.

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