Restoration of Endocrine Function and Fertility With a Tubo-Ovarian Autotransplant as the Anatomical-Functional Unit in Rabbits Using a Vascular Microsurgical Technique

2006 ◽  
Vol 38 (3) ◽  
pp. 945-951 ◽  
Author(s):  
M.M. Meraz ◽  
C.M. Revilla ◽  
C.J.C. Martı́nez ◽  
S. Islas-Andrade ◽  
E.M. Aburto
Keyword(s):  
Functional Unit ◽  
Endocrine Function ◽  
Microsurgical Technique

Restoration of Endocrine Function and Fertility with Orthotopic Tubal—Ovarian Allotransplant as the Anatomical-Functional Unit in Rabbits

2008 ◽  
Vol 21 (6) ◽  
pp. 348-359 ◽  
Author(s):  
Manuel M. Meraz ◽  
Carmen Gracida Juárez ◽  
Cristina Revilla Monsalve ◽  
Juan Carlos Martínez-Chequer ◽  
Jesús Macias Duvignau ◽  
...  
Keyword(s):  
Functional Unit ◽  
Endocrine Function

Placenta and uteroplacental perfusion

2016 ◽  
Author(s):  
Marie-Pierre Bonnet ◽  
Anne Alice Chantry
Keyword(s):  
Regional Anaesthesia ◽  
Functional Unit ◽  
Well Being ◽  
Maternal Blood ◽  
Endocrine Function ◽  
Protective Function ◽  
Uterine Arteries ◽  
Trophoblastic Cells ◽  
Healthy Pregnancy ◽  
Maternal Blood Pressure

The placenta is a complex and changing organ necessary for normal fetal growth and development and for maintenance of a healthy pregnancy. It has three major functions: a protective function of the fetus, an endocrine function, and a metabolic function. The main functional unit of the placenta is the chorionic villous, responsible for the majority of the fetal–maternal exchanges. Migration of trophoblastic cells induces a remodelling of the uterine arteries, with vasodilatated and compliant vessels, unresponsive to maternal vasomotor control. Therefore, any significant change in maternal blood pressure, in particular in the context of general or regional anaesthesia, can directly impact on uteroplacental perfusion. Most anaesthetic drugs cross the placental barrier, but without significant consequences on the fetal well-being.

Pediatric Replantation after Traumatic Amputation at the Distal Forearm: Rehabilitation Protocol and Outcomes

2020 ◽  
Author(s):  
Nicholas C. Oleck ◽  
Radhika Malhotra ◽  
Haripriya S. Ayyala ◽  
Ramazi O. Datiashvili
Keyword(s):  
Operating Room ◽  
Multidisciplinary Team ◽  
Distal Forearm ◽  
Left Forearm ◽  
Traumatic Amputation ◽  
Postoperative Rehabilitation ◽  
Rehabilitation Protocol ◽  
Microsurgical Technique ◽  
Optimal Function ◽  
And Function

AbstractMajor limb replantation is a formidable task, especially in the pediatric setting. While meticulous microsurgical technique is required in the operating room, the authors aim to highlight the importance of postoperative rehabilitation therapy for optimal function. We highlight the case of a 12-year-old boy who suffered complete traumatic amputation through the distal left forearm. The limb was successfully replanted with successful restoration of sensation and function with the aid of intensive postoperative occupational therapy. A multidisciplinary team is of paramount importance to maximize function of a replanted upper extremity.

METABOLIC AND ENDOCRINE ASPECTS OF THE WHIRLER MUTATION IN MALE MICE

1970 ◽  
Vol 64 (2) ◽  
pp. 347-358
Author(s):  
A. Stanley Weltman ◽  
Arthur M. Sackler
Keyword(s):  
Locomotor Activity ◽  
Endocrine Function ◽  
Metabolic Rates ◽  
Heterozygous Female ◽  
Endocrine Organ ◽  
General Body ◽  
Adrenocortical Activity ◽  
Body Weights ◽  
Seminal Vesicle Weight ◽  
Eosinophil Counts

ABSTRACT Body weight, metabolic rate, locomotor activity and alterations in endocrine organ activity were noted in recessive homozygous male whirler mice and the phenotypically »normal« heterozygotes. Representative populations of the two types were studied at different age levels. In general, body weights of the whirler mice were consistently and significantly lower. Open-field locomotion studies similarly indicated heightened locomotor activity. Total leukocyte and eosinophil counts were either markedly or significantly lower in the homozygous vs. heterozygous whirler groups. Evaluation of relative organ weights showed significantly increased adrenal weights in whirler mice sacrificed at 14 weeks and 11 months of age. These changes were accompanied by involution of the thymus. Thus, the varied data indicate persistent increased metabolism and adrenocortical activity during the life-span of the whirler mice. Seminal vesicle weight decreases in the whirler males at 11 months suggest lower gonadal function. The findings are in accord with previous studies of alterations in metabolic rates and endocrine function of homozygous whirler vs. heterozygous female mice.

THE INFLUENCE OF 17α-METHYL-19-NORTESTOSTERONE ON THE ENDOCRINE FUNCTION OF THE ADRENAL CORTEX

1960 ◽  
Vol XXXIII (III) ◽  
pp. 388-400 ◽  
Author(s):  
L. G. Huis in 't Veld ◽  
B. Louwerens ◽  
P. A. F. van der Spek
Keyword(s):  
Urinary Excretion ◽  
Adrenal Cortex ◽  
Direct Effect ◽  
Chorionic Gonadotrophin ◽  
Endocrine Function ◽  
List Type ◽  
Prolonged Administration ◽  
Acth Secretion ◽  
Male Patients ◽  
Normal Males

ABSTRACT In two male patients and two castrated males, the influence of corticotrophin (ACTH) on the urinary excretion of neutral 17-ketosteroids and 17-hydroxycorticosteroids was determined before and during a period in which patients were treated with 5 mg 17α-methyl-19-nortestosterone (MNT) daily. In two castrated males, moreover, the influence of chorionic gonadotrophin and ACTH + chorionic gonadotrophin on the urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids was determined before and during a period of treatment with 5 mg MNT daily. Prolonged administration of MNT causes a decrease in the urinary excretion of neutral 17-ketosteroids and 17-hydroxycorticosteroids both in the normal males and in the male castrates. ACTH caused an increase in the urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids before and during MNT administration. During MNT administration this increase (expressed in mg/24 hours) was ≤ the increase produced by the same dose of ACTH prior to MNT administration. In two male castrates treated with MNT, chorionic gonadotrophin caused no increase in the urinary excretion of 17-ketosteroids and 17-hydroxycorticosteroids. The effect obtained before and during MNT administration by administration of ACTH + chorionic gonadotrophin did not exceed the effect obtained by the same dose of ACTH alone. Our conclusion is that the effect of MNT on the excretion of adrenocortical steroids is not due to the inhibition of the ACTH secretion. The possibility of a direct effect of MNT on the adrenal cortex has not been excluded with complete certainty. A change in the corticosteroid metabolism due to the influence of MNT, however, must also be taken into consideration.

Histology of the vertebral artery–dural junction: relevance to posterolateral approaches to the skull base

2019 ◽  
pp. 1-6
Author(s):  
Robert C. Rennert ◽  
Martin P. Powers ◽  
Jeffrey A. Steinberg ◽  
Takanori Fukushima ◽  
John D. Day ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Vertebral Artery ◽  
Skull Base ◽  
Histological Analysis ◽  
Foramen Magnum ◽  
Entry Site ◽  
Microsurgical Technique ◽  
Vessel Injury ◽  
Far Lateral ◽  
Clear Delineation

OBJECTIVEThe far-lateral and extreme-lateral infrajugular transcondylar–transtubercular exposure (ELITE) and extreme-lateral transcondylar transodontoid (ELTO) approaches provide access to lesions of the foramen magnum, inferolateral to mid-clivus, and ventral pons and medulla. A subset of pathologies in this region require manipulation of the vertebral artery (VA)–dural interface. Although a cuff of dura is commonly left on the VA to avoid vessel injury during these approaches, there are varying descriptions of the degree of VA-dural separation that is safely achievable. In this paper the authors provide a detailed histological analysis of the VA-dural junction to guide microsurgical technique for posterolateral skull base approaches.METHODSAn ELITE approach was performed on 6 preserved adult cadaveric specimens. The VA-dural entry site was resected, processed for histological analysis, and qualitatively assessed by a neuropathologist.RESULTSHistological analysis demonstrated a clear delineation between the intima and media of the VA in all specimens. No clear plane was identified between the connective tissue of the dura and the connective tissue of the VA adventitia.CONCLUSIONSThe VA forms a contiguous plane with the connective tissue of the dura at its dural entry site. When performing posterolateral skull base approaches requiring manipulation of the VA-dural interface, maintenance of a dural cuff on the VA is critical to minimize the risk of vascular injury.

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