Intra-Liver Allograft C3d-Binding Donor-Specific Anti-HLA Antibodies Predict Rejection After Liver Transplantation

2022 ◽  
Author(s):  
Tsukasa Nakamura ◽  
Takayuki Shirouzu ◽  
Ryusuke Sugimoto ◽  
Shumpei Harada ◽  
Mikiko Yoshikawa ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Allograft ◽  
Hla Antibodies

Alkaline phosphatase isoforms in serum after liver allograft surgery

1994 ◽  
Vol 40 (7) ◽  
pp. 1272-1277 ◽  
Author(s):  
J Randolph-Habecker ◽  
J A Lott ◽  
R J Tesi
Keyword(s):  
Liver Transplantation ◽  
Alkaline Phosphatase ◽  
Liver Function Tests ◽  
Clinical Findings ◽  
High Molecular Mass ◽  
Reference Ranges ◽  
Liver Allograft ◽  
Postoperative Course ◽  
End Stage Liver Disease ◽  
End Stage

Abstract Orthotopic liver transplantation (OLT) is now the only available treatment for end-stage liver disease; the major postoperative complications of OLT are rejection and infection. Fractionation of alkaline phosphatase (ALP) isoforms in serum by isoelectric focusing can be used to identify patients with complications. Reference ranges for liver-function tests (LFT) and liver ALP isoforms were established for post-OLT patients with stable postoperative courses and compared with those of patients with complications. We found canalicular, hepatocyte, and high-molecular-mass ALP to be statistically higher in nearly all patients with complications as compared with patients who had a stable postoperative course; these tests may identify patients requiring a liver biopsy. When used in conjunction with LFT and other clinical findings, ALP isoforms could aid in the monitoring of complications and treatment and in the adjustment of immunosuppressive therapy in stable OLT cases.

scholarly journals Th1/Th2cytokines and ICAM–1 levels post-liver transplant do not predict early rejection

2000 ◽  
Vol 9 (1) ◽  
pp. 35-38 ◽  
Author(s):  
E. Granot ◽  
A. Tarcsafalvi ◽  
S. Emre ◽  
P. Sheiner ◽  
S. Guy ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Transplant ◽  
Immunosuppressive Therapy ◽  
Allograft Rejection ◽  
Liver Perfusion ◽  
Percentage Increase ◽  
Plasma Samples ◽  
Liver Allograft ◽  
Predominant Factor ◽  
Ifn Γ

Th1derived cytokines IFN-γ and IL–2, Th2cytokine IL–4, and ICAM–1 have been implicated in liver allograft rejection. In order to determine whether monitoring of cytokine profiles during the first days post-liver transplant can predict early rejection we measured IFN-gg, IL–2, sIL–2 receptor, IL–4 and ICAM–1 in 22 patients, in plasma samples obtained within 4h after liver perfusion (baseline) and between postoperative days (POD) 3–6. ICAM–1 and sIL–2R levels at POD 3–6 were significantly higher than at baseline but did not differ in presence or absence of rejection. Mean percentage increase of ICAM–1 levels was significantly lower in patients with Muromonab-C3Orthoclone OKT3(J.C. Health Care) (OKT3) whereas percentage increase of sIL–2R levels was higher in OKT3-treated patients. IFN-γ levels at POD 3–6 increased from baseline while IL–4 levels were unchanged. Levels of IFN-γ, IL–4 and their ratios did not correlate with rejection or immunosuppressive therapy. Thus, Th1/Th2cytokine monitoring during the first week post-transplant does not predict early rejection and immunosuppressive therapy is the predominant factor affecting ICAM and sIL–2R levels after liver transplantation.

Predicting Operational Tolerance in Pediatric Living-Donor Liver Transplantation by Absence of HLA Antibodies

2013 ◽  
Vol 95 (1) ◽  
pp. 177-183 ◽  
Author(s):  
Kayo Waki ◽  
Yasuhiko Sugawara ◽  
Koichi Mizuta ◽  
Michiko Taniguchi ◽  
Miyuki Ozawa ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Donor Liver ◽  
Hla Antibodies ◽  
Donor Liver Transplantation ◽  
Operational Tolerance

scholarly journals Donor-specific HLA Antibodies Are Associated With Late Allograft Dysfunction After Pediatric Liver Transplantation

2015 ◽  
Vol 99 (7) ◽  
pp. 1416-1422 ◽  
Author(s):  
Laura J. Wozniak ◽  
Michelle J. Hickey ◽  
Robert S. Venick ◽  
Jorge H. Vargas ◽  
Douglas G. Farmer ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Pediatric Liver Transplantation ◽  
Hla Antibodies ◽  
Allograft Dysfunction ◽  
Pediatric Liver

scholarly journals The impact of postreperfusion syndrome on short-term patient and liver allograft outcome in patients undergoing orthotopic liver transplantation

2008 ◽  
Vol 14 (4) ◽  
pp. 504-508 ◽  
Author(s):  
Ibtesam Hilmi ◽  
Charles N. Horton ◽  
Raymond M. Planinsic ◽  
Tetsuro Sakai ◽  
Ramona Nicolau-Raducu ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Short Term ◽  
Liver Allograft ◽  
Allograft Outcome ◽  
The Impact

Liver allograft radiotherapy to treat rejection in children: efficacy in orthotopic liver transplantation and long-term safety

2005 ◽  
Vol 25 (6) ◽  
pp. 1108-1113 ◽  
Author(s):  
Xavier Stephenne ◽  
Mustapha Najimi ◽  
Magda Janssen ◽  
Raymond Reding ◽  
Jean de Ville de Goyet ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Orthotopic Liver Transplantation ◽  
Liver Allograft
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