Towards nanoporous polymer thin film-based drug delivery systems

Over the past few decades, tendency toward innovative drug delivery systems has almightily increased attempts to ensure efficacy, safety and patient acceptability. As discovery and development of new chemical agents is a complex, expensive and time consuming process, so recent trends are shifting toward designing and developing innovative drug delivery systems for existing drugs. Orally fast dissolving film is the kind of drug delivery system which when placed in the oral cavity, disintegrate or dissolve within a few seconds without the intake of water. Oral fast dissolving film is relatively new dosage form in which thin film is prepared using hydrophilic polymers, which rapidly disintegrate or dissolves on tongue or in the buccal cavity It is an alternative platform for molecules that undergoes high first pass metabolism. The method of preparation for oral dissolving film. Solvent casting, Semisolid casting, Hot melt extrusion, Solid dispersion extrusion, Rolling The current evaluation gives an account of different formulations methods of preparation and quality control of the fast dissolving oral thin film. Keyword: First pass metabolism, Tensile strength, Fast Dissolving Oral Film etc.

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Polycaprolactone thin-film drug delivery systems: Empirical and predictive models for device design

Materials Science and Engineering C ◽

10.1016/j.msec.2015.07.027 ◽

2015 ◽

Vol 57 ◽

pp. 232-239 ◽

Cited By ~ 29

Author(s):

Erica Schlesinger ◽

Natalie Ciaccio ◽

Tejal A. Desai

Keyword(s):

Thin Film ◽

Drug Delivery ◽

Predictive Models ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Device Design

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Fast Dissolving Oral Thin Film Drug Delivery Systems Consist of Ergotamine Tartrate and Caffeine Anhydrous

Pharmaceutical Sciences ◽

10.15171/ps.2015.24 ◽

2015 ◽

Vol 21 (2) ◽

pp. 102-110

Author(s):

Mitra Jelvehgari ◽

Seyed Hassan Montazam ◽

Saieede Soltani ◽

Rahil mohammadi ◽

Karim Azar ◽

...

Keyword(s):

Thin Film ◽

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Ergotamine Tartrate ◽

Caffeine Anhydrous

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Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120242 ◽

1985 ◽

Vol 43 ◽

pp. 710-711

Author(s):

G.E. Visscher ◽

R. L. Robison ◽

G. J. Argentieri

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Gastrocnemius Muscle ◽

Degradation Process ◽

Delivery Systems ◽

Tissue Reaction ◽

Electron Microscopic ◽

Tissue Samples ◽

Injectable Polymer ◽

Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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