A katG S315T or an ahpC promoter mutation mediate Mycobacterium tuberculosis resistance to 2-thiophen carboxylic acid hydrazide, an inhibitor resembling the anti-tubercular drugs Isoniazid and Ethionamide

Tuberculosis ◽  
2018 ◽  
Vol 112 ◽  
pp. 69-78 ◽  
Author(s):  
Jorgelina J. Franceschelli ◽  
Juan M. Belardinelli ◽  
Ping Tong ◽  
Brendan Loftus ◽  
Alejandro Recio-Balsells ◽  
...  
1982 ◽  
Vol 89 (2) ◽  
pp. 235-242 ◽  
Author(s):  
C. H. Collins ◽  
M. D. Yates ◽  
J. M. Grange

SUMMARYVirulent strains of Mycobacterium tuberculosis isolated from humans are divisible into five variants by using four tests: oxygen requirement (aerobic or microaerophilic), nitrate reductase activity, susceptibility to pyrazinamide (60 μg/ml) and susceptibility to thiophene-2-carboxylic acid hydrazide (5 μg/ml). The five variants are referred to as Classical human, Asian human, bovine, African I and African II. The relation of these variants to previously described types is discussed. This simple division has been shown to be useful in epidemiological studies.


1985 ◽  
Vol 94 (1) ◽  
pp. 9-21 ◽  
Author(s):  
J. M. Grange ◽  
M. D. Yates ◽  
C. H. Collins

SUMMARYHuman strains ofMycobacterium tuberculosiswere divided into the ‘Classical’ and ‘Asian’ types according to their sensitivity to thiophen-2-carboxylic acid hydrazide. The isolation of these two types in South-East England was studied during a seven-year period (1977–1983). The ‘Asian’ type was more prevalent among ethnic Asian patients than among ethnic Europeans. Among Europeans there was a decline in the isolation rate of ‘Classical’ strains and a small but significant increase in ‘Asian’ strains during the study period, so that the proportion of the latter type in this group is increasing. The type of bacillus was unrelated to the site of isolation except that the incidence of lymphadenitis due to the ‘Asian’ type among European females was significantly higher than expected. In general, European patients tended to be older than Asian patients, and the differences in age distribution according to site of isolation and type of bacillus in each ethnic group were small. A notable exception occurred with European females infected with the ‘Asian’ type, whose age distribution was similar to the Asians.In view of the differences in behaviour of the two types of human tubercle bacilli in this country there is a need to cintinue a bacteriological surveillance and also to determine whether the nature of the host–pathogen interaction varies according to the type of bacillus.


2003 ◽  
Vol 68 (10) ◽  
pp. 723-727 ◽  
Author(s):  
Vijay Dabholkar ◽  
Rahul Gavande

A series of 1-(3,4-dihydro-3-oxo-2H-1,4-benzoxazine-2-carbonyl)-3-methyl-4-(substituted phenylhydrazono)-2-pyrazolin-5-ones have been synthesized by the reaction of 2H-3,4-dihydro-3-oxo-1,4-benzoxazine-2-carboxylic acid hydrazide with substituted acetoacetic ester derivatives using acetic acid as solvent under microwave irradiation (MWI), as well as by conventional methods. The reaction rate is enhanced tremendously and the yields are improved under MWI as compared to conventional methods.


2005 ◽  
Vol 42 (1) ◽  
pp. 117-120 ◽  
Author(s):  
İ Özer İlhan ◽  
Emin Saripinar ◽  
Yunus Akçamur

2018 ◽  
Vol 54 (3) ◽  
pp. 509-511 ◽  
Author(s):  
D. S. Kopchuk ◽  
A. P. Krinochkin ◽  
E. S. Starnovskaya ◽  
Ya. K. Shtaitz ◽  
I. S. Kovalev ◽  
...  

The Analyst ◽  
2014 ◽  
Vol 139 (11) ◽  
pp. 2764-2773 ◽  
Author(s):  
Zhongxin Zhu ◽  
Xuan Zhou ◽  
Yang Wang ◽  
Lisha Chi ◽  
Dandan Ruan ◽  
...  

A sensitive, specific, economic and MS compatible staining method for gel-separated glycoproteins by using BH was described and demonstrated by 1-D and 2-D SDS-PAGE, deglycosylation, glycoprotein affinity enrichment and LC-MS/MS, respectively.


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