COX-2 over-expression correlates with VEGF and tumour angiogenesis in canine mammary cancer

2011 ◽  
Vol 189 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Felisbina L. Queiroga ◽  
Isabel Pires ◽  
Margarida Parente ◽  
Hugo Gregório ◽  
Carlos S. Lopes
Keyword(s):  
Mammary Cancer ◽  
Tumour Angiogenesis ◽  
Over Expression ◽  
Canine Mammary Cancer ◽  
Cox 2

Canine mammary cancer in overweight or obese female dogs is associated with intratumoral microvessel density and macrophage counts

2021 ◽  
pp. 030098582110404
Author(s):  
Ha-Young Lim ◽  
Byung-Joon Seung ◽  
Seung-Hee Cho ◽  
Soo-Hyeon Kim ◽  
Min-Kyung Bae ◽  
...  
Keyword(s):  
Body Weight ◽  
Microvessel Density ◽  
Mammary Cancer ◽  
Ideal Body Weight ◽  
Histologic Grade ◽  
Obese Group ◽  
Canine Mammary Cancer ◽  
Obesity Status ◽  
Ideal Body ◽  
Cox 2

Obesity is a major health condition owing to its effects on chronic diseases and cancers in humans, but little information is available regarding the role of obesity in canine mammary cancer (CMC). In the present study, we performed immunohistochemistry to investigate the effect of obesity on CMC by analyzing the number of tumor-associated macrophages, intratumoral microvessel density (iMVD), and the expression of prognostic factors including epidermal growth factor receptor (EGFR), cyclooxygenase 2 (COX-2), and Ki67 in CMC specimens. These data were compared in CMC specimens from lean or ideal body weight (Group 1) versus overweight or obese (Group 2) female dogs ( n = 60 for each group). Associations between obesity status and histologic characteristics, such as histologic subtype, grading, and lymphatic invasion, were also investigated. Compared with lean or ideal body weight dogs, TAM (tumor-associated macrophage) counts ( P < .005) and iMVD ( P < .001) were significantly higher in overweight or obese dogs. CMC specimens of dogs in the overweight or obese group also showed higher histologic grade ( P < .001). In addition, although no association was found between obesity status and either COX-2 or EGFR expression, Ki67 expression was greater in CMC specimens of overweight or obese dogs ( P < .005). The results of this study suggest that obesity may influence CMC development and progression, being associated with higher histologic grade, greater infiltration of TAMs, and increased tumor angiogenesis.

scholarly journals Over-expression of COX-2 mRNA in colorectal cancer

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Hennie MJ Roelofs ◽  
Rene HM te Morsche ◽  
Bjorn WH van Heumen ◽  
Fokko M Nagengast ◽  
Wilbert HM Peters
Keyword(s):  
Colorectal Cancer ◽  
Over Expression ◽  
Cox 2

scholarly journals Identification of tumour-associated and germ line p53 mutations in canine mammary cancer

1999 ◽  
Vol 81 (3) ◽  
pp. 409-415 ◽  
Author(s):  
N Veldhoen ◽  
J Watterson ◽  
M Brash ◽  
J Milner
Keyword(s):  
Mammary Cancer ◽  
Germ Line ◽  
P53 Mutations ◽  
Canine Mammary Cancer

scholarly journals Molecular iodine/doxorubicin neoadjuvant treatment impair invasive capacity and attenuate side effect in canine mammary cancer

2018 ◽  
Vol 14 (1) ◽  
Author(s):  
Xóchitl Zambrano-Estrada ◽  
Brianda Landaverde-Quiroz ◽  
Andrés A. Dueñas-Bocanegra ◽  
Marco A. De Paz-Campos ◽  
Gerardo Hernández-Alberto ◽  
...  
Keyword(s):  
Side Effect ◽  
Mammary Cancer ◽  
Neoadjuvant Treatment ◽  
Molecular Iodine ◽  
Canine Mammary Cancer ◽  
Invasive Capacity

scholarly journals Evaluation of P53, E-cadherin, Cox-2, and EGFR protein imunnoexpression on prognostic of resected gallbladder carcinoma

2014 ◽  
Vol 27 (2) ◽  
pp. 126-132 ◽  
Author(s):  
Sergio Renato PAIS-COSTA ◽  
José Francisco de Matos FARAH ◽  
Ricardo ARTIGIANI-NETO ◽  
Sandro José MARTINS ◽  
Alberto GOLDENBERG
Keyword(s):  
Gallbladder Carcinoma ◽  
Radical Resection ◽  
Total Sample ◽  
Palliative Surgery ◽  
Over Expression ◽  
Dismal Prognosis ◽  
Gallbladder Adenocarcinoma ◽  
Independent Variable ◽  
Cox 2 ◽  
E Cadherin

BACKGROUND: Gallbladder carcinoma presents a dismal prognosis. Choice treatment is surgical resection that is associated a high levels of both morbidity and mortality. Best knowledgement of prognostic factors may result a better selection of patients either for surgical or multimodal treatment. AIM: To evaluate tecidual immunoexpression of P53, E-cadherin, Cox-2, and EGFR proteins and to correlate these findings with resected gallbladder adenocarcinoma survival. METHODS: Clinical, laboratorial, surgical, and anatomopathological reports of a series of gallbladder adenocarcinoma patients were collected by individualized questionary. Total sample was 42 patients. Median of age was 72 years (35-87). There were seven men and 35 women. Lesion distribuition in according TNM state was the following: T1 (n=2), T2 (n=5), T3 (n=31), T4 (n=4). Twenty-three patients underwent radical resection (R0), while 19 palliative surgery (R1-R2). A block of tissue microarray with neoplasic tissue of each patient was confected. It was performed evaluation of P53, E-Caderine, COX-2, and EGFR proteins imunoexpression. These findings were correlated with overall survival. RESULTS: Five-year survival was 28%. The median of global survival was eight months. Only immunoexpression of EGFR protein was considered independent variable at multivariated analysis. CONCLUSION: Final prognosis was influenced by over-expression of EGFR protein in tumoral tissue.

Different role of COX-2 and angiogenesis in canine inflammatory and non-inflammatory mammary cancer

2013 ◽  
Vol 197 (2) ◽  
pp. 427-432 ◽  
Author(s):  
Mónica Clemente ◽  
Ana Rodríguez Sánchez-Archidona ◽  
David Sardón ◽  
Lucía Díez ◽  
Asunción Martín-Ruiz ◽  
...  
Keyword(s):  
Mammary Cancer ◽  
Cox 2

scholarly journals Canine mammary cancer

2020 ◽  
Vol 51 (4) ◽  
pp. 425-439
Author(s):  
Alejandro Clavijo-Maldonado ◽  
Enio Ferreira ◽  
Carlos Vargas-Hernández ◽  
Fredy A. Rivera-Páez
Keyword(s):  
Mammary Cancer ◽  
Cellular Proliferation ◽  
Mammary Tissue ◽  
Clinical Approach ◽  
Comparative Oncology ◽  
Clinical Prognosis ◽  
Canine Mammary Cancer ◽  
Clinical Relationship ◽  
Her 2 ◽  
Poor Clinical Prognosis

Canine mammary cancer (CMC) is one of the most common neoplasms in intact females in comparison to other species. Several risk factors have been identified, including breed, genetic predisposition, age, reproductive history, hormonal influence, diet, and body condition, in addition to previous lesions to the mammary gland, such as mammary atypical hyperplasia. An understanding of the genetic markers for the disease and a clinical approach are important for establishing a specific therapy that can allow adequate patient survivorship. Overexpression of the HER-2 gene in canines and humans is associated with a poor clinical prognosis, mainly short survivorship, although the clinical relationship is not clear. The incidence of HER-2 in female dogs can range from 29.7% to 38%. However, overexpression of HER-2 is not necessarily associated with malignancy processes of the mammary tissue, although it participates in cellular proliferation. Finally, canines remain one of the most important models for comparative oncology with humans due to the great similarity in the spontaneous presentation and development of cancer, and in the high homology in the amino acid sequence.

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