Comparison of Sound Touch Elastography, Shear Wave Elastography and Vibration-Controlled Transient Elastography in Chronic Liver Disease Assessment using Liver Biopsy as the “Reference Standard”

we aim to compare transient elastography and shear wave elastography in chronic liver disease patients for liver stiffness. Our objective was to calculate mean shear wave pressure by transient elastography and shear wave elastography methods and to compare the outcome of these two methods.A total of 190 Chronic Liver disease patients who clinically recommended transient elastography and shear wave elastography in Department of Radiodiagnosis SMS Medical College Jaipur.The mean shear wave pressure for transient elastography and ultrasound shear wave elastography was 10.77±6.88 and 10.88±7.05, respectively.

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The Diagnostic Accuracy of LOGIQ S8 and E9 Shear Wave Elastography for Staging Hepatic Fibrosis, in Comparison with Transient Elastography

Diagnostics ◽

10.3390/diagnostics11101817 ◽

2021 ◽

Vol 11 (10) ◽

pp. 1817

Author(s):

Jeong-Ju Yoo ◽

Sang Gyune Kim ◽

Young Seok Kim

Keyword(s):

Liver Cirrhosis ◽

Liver Disease ◽

Liver Fibrosis ◽

Chronic Liver Disease ◽

Shear Wave ◽

Transient Elastography ◽

Liver Stiffness ◽

Shear Wave Elastography ◽

Chronic Liver ◽

Significant Fibrosis

Background: The aim of this study was to evaluate the usefulness of two different types of 2-dimensional shear wave elastography (2D-SWE) for predicting liver fibrosis stages in comparison to transient elastography (TE), using a histologic METAVIR scoring system as the reference method. Methods: A total of 203 patients with chronic liver disease were prospectively enrolled in the study. Two different 2D-SWEs (LOGIQ S8 and E9 systems, GE Healthcare, Chalfont St Giles, UK) were assessed for liver stiffness in patients with chronic liver diseases. Patients received 2D-SWE examinations with the S8 and E9 systems, and also underwent TE (FibroScan®, Echosens, France) tests and liver biopsies on the same day. Results: The most common etiology of chronic liver disease was non-alcoholic fatty liver disease (28.7%), followed by chronic hepatitis B (25.1%). Liver fibrosis stages consisted of F0 (22.6%), F1 (29.7%), F2 (16.9%), F3 (12.8%) and F4 (17.9%). Overall, S8 and E9 were well correlated with the histologic fibrosis stages. The optimal cut-off values for S8 and E9 to differentiate significant fibrosis (≥F2) were 6.70 kPa and 6.42 kPa, respectively, while the cut-off values for S8 and E9 in distinguishing liver cirrhosis were 9.15 kPa and 8.88 kPa, respectively. Among the 195 patients who had successful measurements in both S8 and E9, liver stiffness showed good inter-equipment correlation (ICC: 0.900, p < 0.001). Regarding diagnostic ability, upon comparison (FibroScan®), there were no significant differences between 2D-SWEs and TE for detecting every stage of liver fibrosis. Conclusion: In comparison to TE, 2D-SWE with LOGIQ S8 and E9 (GE Healthcare) are useful non-invasive tools for predicting significant fibrosis and liver cirrhosis.

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Deep learning networks on chronic liver disease assessment with fine-tuning of shear wave elastography image sequences

Physics in Medicine and Biology ◽

10.1088/1361-6560/abae06 ◽

2020 ◽

Vol 65 (21) ◽

pp. 215027

Author(s):

George C Kagadis ◽

Petros Drazinos ◽

Ilias Gatos ◽

Stavros Tsantis ◽

Panagiotis Papadimitroulas ◽

...

Keyword(s):

Deep Learning ◽

Liver Disease ◽

Chronic Liver Disease ◽

Shear Wave ◽

Shear Wave Elastography ◽

Image Sequences ◽

Chronic Liver ◽

Fine Tuning ◽

Disease Assessment ◽

Learning Networks

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Role of Shear Wave Elastography in the Assessment of Fibrosis in Chronic Liver Disease

Journal of Diagnostic Medical Sonography ◽

10.1177/8756479318799340 ◽

2018 ◽

Vol 34 (6) ◽

pp. 460-465

Author(s):

Sravya Bellamkonda ◽

Samir M. Paruthikunnan ◽

Rajagopal Kadavigere ◽

Smiti Sripathi

Keyword(s):

Liver Disease ◽

Chronic Liver Disease ◽

Shear Wave ◽

Diagnostic Performance ◽

Shear Wave Elastography ◽

Serum Markers ◽

Chronic Liver ◽

Reference Standard ◽

Roc Curve Analysis

Objective: To evaluate the diagnostic performance of shear wave elastography in the estimation of fibrosis in patients with chronic liver disease by using biopsy and/or serum markers as reference standard. Materials and methods: 100 patients underwent point quantification-shear wave elastography, for whom noninvasive serum fibrosis indices like APRI, FIB-4, and King’s score were calculated. The receiver-operator characteristic (ROC) curve analysis was performed. Results: The shear wave elastography measurements showed moderate agreement with APRI, FIB-4, and fair agreement with King’s score. The AUROC for differentiating F0-F1, F2-F3, F2-F3, and F4 are 0.873 and 0.504 respectively using APRI as reference standard. The cutoff values derived for differentiating F0-F1 and F2-F3 was 7.07 and for differentiating F2-F3 and F4 was 11.94. Conclusion: The diagnostic performance of shear wave elastography is comparable with that of serum fibrosis indices APRI and FIB-4.

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Comparison between shear wave elastography and serological findings for the evaluation of fibrosis in chronic liver disease

Journal of Ultrasonography ◽

10.15557/jou.2021.0030 ◽

2021 ◽

Vol 21 (86) ◽

pp. e186-e193

Author(s):

Mahjabeen Liaqat ◽

◽

Kashif Siddique ◽

Imran Yousaf ◽

Raham Bacha ◽

...

Keyword(s):

Liver Disease ◽

Liver Fibrosis ◽

Diagnostic Accuracy ◽

Chronic Liver Disease ◽

Shear Wave ◽

Shear Wave Elastography ◽

Chronic Liver ◽

Optimal Cutoff ◽

Cutoff Value ◽

Cutoff Values

Aim: In this study, we sought to examine the optimal cutoff values for predicting different stages of liver fibrosis, and to determine the level of agreement between shear wave elastography and aspartate aminotransferase to platelet ratio index (APRI) and fibrosis-4 index (FIB-4) scores in patients with chronic liver disease. Methodology: A descriptive, cross-sectional study was performed at the Radiology Department of Shaukat Khanum Memorial Hospital Lahore from 1 Jun 2019 until 1 June 2020. FIB-4 and APRI scores were determined by the following formula: FIB-4 = (age × AST) ÷ (platelet count × (√ (ALT)) and APRI = (AST÷AST upper limit of normal) ÷ platelet × 100. Data was analyzed with the help of SPSS version 24.0 and Microsoft Excel 2013. Results: Eighty individuals were conveniently selected, of which 62.5% were men and 37.5% were women. The mean age of the subjects was 43.47 SD ± 13.85 years. APRI and FIB-4 scores predicted F4 patients using the cutoff values of 0.47 (Sn. 72%, Sp. 70%) and 1.27 (Sn. 78%, Sp. 73%), respectively. The cutoff values of 0.46 for APRI and 1.27 for FIB-4 predicted F3–F4 patients (Sn. 74% and 77%; Sp. 76% and 76%), respectively. To predict F1–F4 compared to F0, the cutoff value was 0.34 (Sn. 68%, Sp. 75%) for APRI, while the cutoff value for FIB was 0.87 (Sn. 72%, Sp. 75%). The findings suggest that FIB-4 shows better diagnostic accuracy than APRI. Conclusion: This study provides optimal cutoff values for different groups of fibrosis patients for both serum markers. Also, the diagnostic accuracy of FIB-4 for predicting liver fibrosis was found to be superior to APRI in all disease stages.

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Liver Stiffness Assessed by Ultrasound Shear Wave Elastography from General Electric Accurately Predicts Clinically Significant Portal Hypertension in Patients with Advanced Chronic Liver Disease

Ultraschall in der Medizin - European Journal of Ultrasound ◽

10.1055/a-0965-0745 ◽

2019 ◽

Vol 41 (05) ◽

pp. 526-533

Author(s):

Horia Stefanescu ◽

Corina Rusu ◽

Monica Lupsor-Platon ◽

Oana Nicoara Farcau ◽

Petra Fischer ◽

...

Keyword(s):

Portal Hypertension ◽

Liver Disease ◽

Diagnostic Accuracy ◽

Chronic Liver Disease ◽

Shear Wave ◽

Liver Stiffness ◽

Shear Wave Elastography ◽

Chronic Liver ◽

General Electric ◽

Clinically Significant

Abstract Purpose Clinically significant portal hypertension (CSPH) is responsible for most of the complications in patients with cirrhosis. Liver stiffness (LS) measurement by vibration-controlled transient elastography (VCTE) is currently used to evaluate CSPH. Bi-dimensional shear wave elastography from General Electric (2D-SWE.GE) has not yet been validated for the diagnosis of PHT. Our aims were to test whether 2D-SWE.GE-LS is able to evaluate CSPH, to determine the reliability criteria of the method and to compare its accuracy with that of VCTE-LS in this clinical setting. Materials and Methods Patients with chronic liver disease referred to hepatic catheterization (HVPG) were consecutively enrolled. HVPG and LS by both VCTE and 2D-SWE.GE were performed on the same day. The diagnostic performance of each LS method was compared against HVPG and between each other. Results 2D-SWE.GE-LS was possible in 123/127 (96.90 %) patients. The ability to record at least 5 LS measurements by 2D-SWE.GE and IQR < 30 % were the only features associated with reliable results. 2D-SWE.GE-LS was highly correlated with HVPG (r = 0.704; p < 0.0001), especially if HVPG < 10 mmHg and was significantly higher in patients with CSPH (15.52 vs. 8.14 kPa; p < 0.0001). For a cut-off value of 11.3 kPa, the AUROC of 2D-SWE.GE-LS to detect CSPH was 0.91, which was not inferior to VCTE-LS (0.92; p = 0.79). The diagnostic accuracy of LS by 2D-SWE.GE-LS to detect CSPH was similar with the one of VCTE-LS (83.74 % vs. 85.37 %; p = 0.238). The diagnostic accuracy was not enhanced by using different cut-off values which enhanced the sensitivity or the specificity. However, in the subgroup of compensated patients with alcoholic liver disease, 2D-SWE.GE-LS classified CSPH better than VCTE-LS (93.33 % vs. 85.71 %, p = 0.039). Conclusion 2D-SWE.GE-LS has good accuracy, not inferior to VCTE-LS, for the diagnosis of CSPH.

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