Differential Imaging of Liver Tumors before and after Microwave Ablation with Electrode Displacement Elastography

2021 ◽  
Author(s):  
Robert M. Pohlman ◽  
James L. Hinshaw ◽  
Timothy J. Ziemlewicz ◽  
Meghan G. Lubner ◽  
Shane A. Wells ◽  
...  
Keyword(s):  
Microwave Ablation ◽  
Liver Tumors ◽  
Before And After ◽  
Electrode Displacement ◽  
Differential Imaging

scholarly journals The impact of microbubble-enhanced therapeutic ultrasound combined with prothrombin on microwave ablation in the rabbit liver.

2016 ◽  
Vol 18 (4) ◽  
pp. 438
Author(s):  
Ying Shi ◽  
Xinyue Liu ◽  
Zhenli Luo ◽  
Fen Gu ◽  
Jianguo He ◽  
...  
Keyword(s):  
Microwave Ablation ◽  
Liver Perfusion ◽  
Therapeutic Ultrasound ◽  
Endothelial Damage ◽  
Cell Ultrastructure ◽  
Rabbit Liver ◽  
Pathological Examination ◽  
Pathologic Examination ◽  
Before And After ◽  
The Impact

Aim: This study aimed to investigate the effect of microbubble-enhanced ultrasound (MEUS) combined with prothrombin on regional hepatic circulation and microwave ablation (MWA) in rabbit livers. Materials and methods: High-pressureamplitude therapeutic ultrasound (TUS) was used to treat 52 surgically exposed livers of healthy New Zealand rabbits: 13 livers were treated with MEUS alone, 13 with MEUS and prothrombin (PMEUS), 13 with ultrasound plus normal saline and 13 with ultrasound plus prothrombin as controls. Contrast-enhanced ultrasound (CEUS) imaging was performed on the exposed livers before and after treatment, and acoustic quantification was done to assess liver perfusion. Then, the liver was divided into two parts, one was used for pathologic examination and the other was ablated with microwave (MWA) and then processedfor pathologic examination. Results: The CEUS images and Peak value after treatment in the PMEUS group were significantly reduced as compared to the remaining 3 groups (p<0.05). Occasional piecemeal hemorrhage was evidenced in the pathological examination in the MEUS group. Obvious cellular degeneration and necrosis with thrombosis were observed in the PMEUS group. Electron microscopy showed endothelial damage in both the MEUS group and PMEUS group. After MWA, coagulated volumes (V) in the PMEUS group were larger than in the remaining 3 groups (p<0.05). The cell ultrastructure disorder wasmore severe in the PMEUS group than in remaining 3 groups. Conclusion: PMEUS promotes endothelial injury and produces more obvious thrombotic occlusion, improving the therapeutic effect of MWA on the rabbit liver. 

scholarly journals 3D Quantitative Ablation Margins for Prediction of Ablation Site Recurrence After Stereotactic Image-Guided Microwave Ablation of Colorectal Liver Metastases: A Multicenter Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Simeon J. S. Ruiter ◽  
Pascale Tinguely ◽  
Iwan Paolucci ◽  
Jennie Engstrand ◽  
Daniel Candinas ◽  
...  
Keyword(s):  
Liver Metastases ◽  
Multicenter Study ◽  
Microwave Ablation ◽  
Colorectal Liver Metastases ◽  
Liver Tumors ◽  
Three Dimensional ◽  
Multivariable Logistic Regression Analysis ◽  
Tumor Diameter ◽  
Ablation Margin ◽  
The Impact

BackgroundThree-dimensional (3D) volumetric ablation margin assessment after thermal ablation of liver tumors using software has been described, but its predictive value on treatment efficacy when accounting for other factors known to correlate ablation site recurrence (ASR) remains unknown.PurposeTo investigate 3D quantitative ablation margins (3D-QAMs) as an algorithm to predict ASR within 1 year after stereotactic microwave ablation (SMWA) for colorectal liver metastases (CRLM).Materials and MethodsSixty-five tumors in 47 patients from a prospective multicenter study of patients undergoing SMWA for CRLM were included in this retrospective 3D-QAM analysis. Using a previously developed algorithm, 3D-QAM defined as the distribution of tumor to ablation surface distances was assessed in co-registered pre- and post-ablation CT scans. The discriminatory power and optimal cutoff values for 3D-QAM were assessed using receiver operating characteristic (ROC) curves. Multivariable logistic regression analysis using generalized estimating equations was applied to investigate the impact of various 3D-QAM outputs on 1-year ASR while accounting for other known influencing factors.ResultsTen of the 65 (15.4%) tumors included for 3D-QAM analysis developed ASR. ROC analyses identified i) 3D-QAM &lt;1 mm for &gt;23% of the tumor surface, ii) 3D-QAM &lt;5 mm for &gt;45%, and iii) the minimal ablation margin (MAM) as the 3D-QAM outputs with optimal discriminatory qualities. The multivariable regression model without 3D-QAM yielded tumor diameter and KRAS mutation as 1-year ASR predictors. When adding 3D-QAM, this factor became the main predictor of 1-year ASR [odds ratio (OR) 21.67 (CI 2.48, 165.21) if defined as &gt;23% &lt;1 mm; OR 0.52 (CI 0.29, 0.95) if defined as MAM].Conclusions3D-QAM allows objectifiable and standardized assessment of tumor coverage by the ablation zone after SMWA. Our data shows that 3D-QAM represents the most important factor predicting ASR within 1 year after SMWA of CRLM.

Laparoscopic image-based navigation for microwave ablation of liver tumors—A multi-center study

2017 ◽  
Vol 31 (10) ◽  
pp. 4315-4324 ◽  
Author(s):  
Pascale Tinguely ◽  
Matteo Fusaglia ◽  
Jacob Freedman ◽  
Vanessa Banz ◽  
Stefan Weber ◽  
...  
Keyword(s):  
Microwave Ablation ◽  
Liver Tumors ◽  
Multi Center Study ◽  
Center Study

scholarly journals Improvement of the primary efficacy of microwave ablation of malignant liver tumors by using a robotic navigation system

2020 ◽  
Vol 54 (3) ◽  
pp. 295-300
Author(s):  
Jan Schaible ◽  
Benedikt Pregler ◽  
Niklas Verloh ◽  
Ingo Einspieler ◽  
Wolf Bäumler ◽  
...  
Keyword(s):  
Tumor Size ◽  
Microwave Ablation ◽  
Liver Tumors ◽  
Multiple Logistic Regression Analysis ◽  
Percutaneous Ablation ◽  
Primary Efficacy ◽  
Robotic Navigation ◽  
Liver Malignancies ◽  
Small Tumor ◽  
Small Tumor Size

AbstractBackgroundThe aim of the study was to assess the primary efficacy of robot-assisted microwave ablation and compare it to manually guided microwave ablation for percutaneous ablation of liver malignancies.Patients and methodsWe performed a retrospective single center evaluation of microwave ablations of 368 liver tumors in 192 patients (36 female, 156 male, mean age 63 years). One hundred and nineteen ablations were performed between 08/2011 and 03/2014 with manual guidance, whereas 249 ablations were performed between 04/2014 and 11/2018 using robotic guidance. A 6-week follow-up (ultrasound, computed tomography and magnetic resonance imaging) was performed on all patients.ResultsThe primary technique efficacy outcome of the group treated by robotic guidance was significantly higher than that of the manually guided group (88% vs. 76%; p = 0.013). Multiple logistic regression analysis indicated that a small tumor size (≤ 3 cm) and robotic guidance were significant favorable prognostic factors for complete ablation.ConclusionsIn addition to a small tumor size, robotic navigation was a major positive prognostic factor for primary technique efficacy.

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