Prostate Volume and Pathologic Prostate Cancer Outcomes After Radical Prostatectomy

Urology ◽  
2007 ◽  
Vol 70 (4) ◽  
pp. 696-701 ◽  
Author(s):  
Phillip M. Pierorazio ◽  
Michael D. Kinnaman ◽  
Matthew S. Wosnitzer ◽  
Mitchell C. Benson ◽  
James M. McKiernan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Prostate Volume ◽  
Cancer Outcomes

1885: Prostate Volume and Pathologic Prostate Cancer Outcomes Following Radical Prostatectomy

2007 ◽  
Vol 177 (4S) ◽  
pp. 626-627
Author(s):  
Phillip M. Pierorazio ◽  
Michael D. Kinnaman ◽  
Matthew S. Wosnitzer ◽  
Mitchell C. Benson ◽  
James M. McKiernan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Prostate Volume ◽  
Cancer Outcomes

scholarly journals Clinical and pathological variables that predict changes in tumour grade after radical prostatectomy in patients with prostate cancer

2013 ◽  
Vol 7 (1-2) ◽  
pp. 93 ◽  
Author(s):  
Stavros Sfoungaristos ◽  
Petros Perimenis
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Gleason Score ◽  
Prostate Volume ◽  
Specific Antigen ◽  
Secondary Analysis ◽  
Intraepithelial Neoplasia ◽  
Treatment Modalities ◽  
Psa Density ◽  
Group 2

Introduction: Preoperative Gleason score is crucial, in combination with other preoperative parameters, in selecting the appropriate treatment for patients with clinically localized prostate cancer. The aim of the present study is to determine the clinical and pathological variables that can predict differences in Gleason score between biopsy and radical prostatectomy.Methods: We retrospectively analyzed the medical records of 302 patients who had a radical prostatectomy between January 2005 and September 2010. The association between grade changes and preoperative Gleason score, age, prostate volume, prostate-specific antigen (PSA), PSA density, number of biopsy cores, presence of prostatitis and high-grade prostatic intraepithelial neoplasia was analyzed. We also conducted a secondary analysis of the factors that influence upgrading in patients with preoperative Gleason score ≤6 (group 1) and downgrading in patients with Gleason score ≤7 (group 2).Results: No difference in Gleason score was noted in 44.3% of patients, while a downgrade was noted in 13.7% and upgrade in 42.1%. About 2/3 of patients with a Gleason score of ≤6 upgraded after radical prostatectomy. PSA density (p = 0.008) and prostate volume (p = 0.032) were significantly correlated with upgrade. No significant predictors were found for patients with Gleason score ≤7 who downgraded postoperatively.Conclusion: Smaller prostate volume and higher values of PSA density are predictors for upgrade in patients with biopsy Gleason score ≤6 and this should be considered when deferred treatment modalities are planned.

scholarly journals Gene expression signature of Gleason score is associated with prostate cancer outcomes in a radical prostatectomy cohort

Oncotarget ◽  
2017 ◽  
Vol 8 (26) ◽  
pp. 43035-43047 ◽  
Author(s):  
Min A. Jhun ◽  
Milan S. Geybels ◽  
Jonathan L. Wright ◽  
Suzanne Kolb ◽  
Craig April ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Gleason Score ◽  
Gene Expression Signature ◽  
Cancer Outcomes ◽  
Expression Signature

scholarly journals Effect of metformin on prostate cancer outcomes after radical prostatectomy

2014 ◽  
Vol 32 (1) ◽  
pp. 43.e1-43.e7 ◽  
Author(s):  
Dharam Kaushik ◽  
R. Jeffrey Karnes ◽  
Manuel S. Eisenberg ◽  
Laureano J. Rangel ◽  
Rachel E. Carlson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Cancer Outcomes

Can mpMRI predict biochemical recurrence after radical prostatectomy? Implications for preoperative staging and surgical planning.

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 161-161
Author(s):  
Richard Ho ◽  
Arvin Koruthu George ◽  
Thomas P Frye ◽  
Steven Abboud ◽  
Raju Chelluri ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Biochemical Recurrence ◽  
Surgical Planning ◽  
Prostate Volume ◽  
Preoperative Staging ◽  
Bivariate Analysis ◽  
Gleason Grade ◽  
Imaging Features ◽  
Patient Counseling

161 Background: Multiparametric magnetic resonance imaging (mpMRI) used in conjunction with MR/TRUS fusion-guided biopsy has improved detection and localization of clinically significant prostate cancer. We aim to evaluate the utility of preoperative MRI characteristics to predict biochemical recurrence (BCR) following radical prostatectomy. Methods: Patients who underwent robotic assisted radical prostatectomy (RARP) between 2007-2014 at the National Institutes of Health were reviewed. We identified patients with BCR defined following the guidelines of the AUA Localized Prostate Cancer Update Panel report (serum PSA ≥0.2 ng/ml with a subsequent confirmatory value). Bivariate analysis and logistic regression were used to determine the association of mpMRI and preoperative patient characteristics with BCR. Results: Of 365 patients who had RARP, 21 met criteria for BCR with a median follow up of 19 months (IQR: 10-34). Mean preoperative PSA (ng/mL) [p<0.001], high MRI suspicion level [p=0.016], presence of extracapsular extension (ECE) on MRI [p=0.003], and total prostate volume by MRI (cc) [p<0.001] were associated with BCR. Increasing MRI suspicion corresponded to increases in rates of BCR within suspicion levels (2.22% of low, 3.88% of moderate, and 10.64% of high). The rates of BCR were significantly greater in men with ECE on final pathology [p<0.001]. Gleason grade trended toward significance [p=0.058]. Controlling for potentially confounding preoperative variables on multivariate analysis, MRI suspicion score, ECE on MRI, and total prostate volume by MRI remained significantly associated with predicting BCR. Conclusions: MRI suspicion score, ECE on mpMRI, and total prostate volume were associated with BCR in patients undergoing RARP. Preoperative mpMRI characteristics aid in risk stratification, patient counseling, and modification of surgical technique in those with high risk imaging features for BCR. The integration of mpMRI characteristics into a comprehensive model of BCR may provide robust tools for preoperative staging and surgical planning.

scholarly journals The association between tumour density and prostate cancer recurrence following radical prostatectomy

2013 ◽  
Vol 5 (6) ◽  
pp. 397
Author(s):  
Luke T. Lavallée ◽  
Rodney H. Breau ◽  
Mark A. Preston ◽  
Gayanna Raju ◽  
Christopher Morash ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Prostate Volume ◽  
Specific Antigen ◽  
Area Under The Curve ◽  
Cancer Recurrence ◽  
Tumour Volume ◽  
Continuous Variable ◽  
Clinical Value ◽  
Discriminative Performance

Purpose: Tumour density (TD) may be an independent prognosticfactor in men with prostate cancer. The purpose of this study wasto evaluate the association between prostate cancer TD and recurrencefollowing radical prostatectomy.Materials and Methods: Between 1995 and 2007, 645 patientsfrom The Ottawa Hospital or Memorial Sloan-Kettering CancerCenter who had cancer and prostate volumes measured from radicalprostatectomy specimens. Tumour density was defined as therelative tumour to prostate volume (tumour volume/prostate volume)and recurrence was defined as a prostate-specific antigen(PSA) >0.2 ng/mL and rising, or postoperative use of radiation orhormonal therapy. Associations between TD and recurrence areadjusted for preoperative PSA, prostatectomy Gleason sum, tumourstage and margin status.Results: Median follow-up was 40.8 months. Tumour density wasassociated with preoperative PSA, Gleason sum, tumour stage andsurgical margin status (all p < 0.0001). As a continuous variable,TD predicted recurrence-free survival (adjusted HR 1.34 per 10%increase in TD; p = 0.04). As a categorical variable, the groupof patients with a TD of >10% had a 2.7 times greater hazard ofrecurrence compared to patients with a TD <5% (95%CI 1.41,5.19; p = 0.003). Despite the independent association betweenTD and recurrence, the clinical value of TD remains in question asthe discriminative performance (area under the curve) of predictivemodels only improved from 0.865 to 0.876.Conclusions: Prostate cancer TD is associated with known prognosticfactors and is also independently predictive of recurrencefollowing radical prostatectomy.

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