MP-03.09 Comparison Between PSA Kinetics and the Detection of Circulating Prostate Cells and Bone Marrow Micrometastasis to Determine Local or Systemic Biochemical Failure after Radical Prostatectomy: Clinical Implications

Urology ◽  
2011 ◽  
Vol 78 (3) ◽  
pp. S43-S44
Author(s):  
N. Murray ◽  
E. Reyes ◽  
N. Orellana ◽  
A. Andrusco ◽  
E. Badinez
Keyword(s):  
Bone Marrow ◽  
Radical Prostatectomy ◽  
Biochemical Failure ◽  
Clinical Implications ◽  
Psa Kinetics ◽  
Prostate Cells ◽  
Bone Marrow Micrometastasis

Presence of circulating prostate cells in the bone marrow of patients undergoing radical prostatectomy is predictive of disease-free survival.

1997 ◽  
Vol 15 (12) ◽  
pp. 3451-3457 ◽  
Author(s):  
D P Wood ◽  
M Banerjee
Keyword(s):  
Bone Marrow ◽  
Radical Prostatectomy ◽  
Proportional Hazards ◽  
Specific Antigen ◽  
Disease Free Survival ◽  
Local Therapy ◽  
Rt Pcr ◽  
Free Survival ◽  
Prostate Cells ◽  
Disease Free

PURPOSE To determine whether the presence of circulating prostate cells in the bone marrow is associated with disease-free survival in patients undergoing radical prostatectomy. MATERIALS AND METHODS We evaluated the bone marrow of 86 patients with clinically localized prostate cancer treated by radical prostatectomy for the presence of circulating prostate cells using reverse-transcriptase polymerase chain reaction (RT-PCR) amplification of prostate-specific antigen (PSA) mRNA. Follow-up duration ranged from 1 to 43 months (mean, 15.4). RESULTS Two of 47 patients (4%) with negative RT-PCR PSA results and 10 of 39 patients (26%) with positive RT-PCR PSA results have had disease recurrence. Patients whose RT-PCR PSA results were positive had a significantly shorter disease-free survival period than those patients with negative RT-PCR PSA results (P = .004). RT-PCR status correlated significantly with serum PSA level (P = .001) and pathologic stage (P = .003). Based on Cox's proportional hazards models, RT-PCR status was found to be a significant predictor of disease-free survival. However, after controlling for PSA level, RT-PCR status was not significant in predicting disease-free survival. CONCLUSION RT-PCR PSA of bone marrow may be a useful pretreatment prognostic test for patients undergoing radical prostatectomy. Currently, this test should not be used to determine if patients receive definitive local therapy.

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