Rabies post-exposure prophylaxis vaccination with purified chick embryo cell vaccine (PCECV) and purified vero cell rabies vaccine (PVRV) in a four-site intradermal schedule (4-0-2-0-1-1): An immunogenic, cost-effective and practical regimen

Vaccine ◽  
2006 ◽  
Vol 24 (19) ◽  
pp. 4116-4121 ◽  
Author(s):  
A AMBROZAITIS ◽  
A LAISKONIS ◽  
L BALCIUNIENE ◽  
A BANZHOFF ◽  
C MALERCZYK
Keyword(s):  
Chick Embryo ◽  
Vero Cell ◽  
Cost Effective ◽  
Embryo Cell ◽  
Rabies Vaccine ◽  
Cell Vaccine ◽  
Post Exposure Prophylaxis ◽  
Post Exposure ◽  
Chick Embryo Cell ◽  
Exposure Prophylaxis

scholarly journals Safety and Immunogenicity of purified chick embryo cell rabies vaccine (VaxiRab N) administered intradermally as post exposure prophylaxis

2014 ◽  
Vol 10 (8) ◽  
pp. 2433-2437 ◽  
Author(s):  
Hardanahalli S Ravish ◽  
Veena Vijayashankar ◽  
Shampur N Madhusudana ◽  
Mysore K Sudarshan ◽  
Doddabele HA Narayana ◽  
...  
Keyword(s):  
Chick Embryo ◽  
Embryo Cell ◽  
Rabies Vaccine ◽  
Post Exposure Prophylaxis ◽  
Post Exposure ◽  
Chick Embryo Cell ◽  
Exposure Prophylaxis

scholarly journals Purified chick embryo cell rabies vaccine: economical multisite intradermal regimen for post-exposure prophylaxis

1987 ◽  
Vol 99 (3) ◽  
pp. 755-765 ◽  
Author(s):  
Pravan Suntharasamai ◽  
M. J. Warrell ◽  
Chaisin Viravan ◽  
Pornthep Chanthavanich ◽  
Sornchai Looareesuwan ◽  
...  
Keyword(s):  
Chick Embryo ◽  
Embryo Cell ◽  
Rabies Vaccine ◽  
Human Rabies ◽  
Post Exposure Prophylaxis ◽  
Protective Efficiency ◽  
Vaccine Regimen ◽  
Post Exposure ◽  
Chick Embryo Cell ◽  
Exposure Prophylaxis

SUMMARYThe standard six-dose intramuscular (i.m.) rabies post-exposure vaccine regimen using a new purified chick embryo cell (PCEC) vaccine was compared with two economical multisite intradermal (i.d.) PCEC regimens, a multisite i.m. PCEC schedule and a subcutaneous regimen using a suckling mouse brain (SMB) rabies vaccine manufactured in Thailand. The neutralizing antibody results for the four-site and eight-site i.d. and the standard i.m. PCEC regimens were similar over 3 months. A three-site i.m. PCEC regimen had no advantage. The SMB vaccine gave the lowest antibody levels. Human rabies immune globulin therapy significantly increased the GMT of all groups on day 7, unlike equine antirabies serum (EARS). Both antisera suppressed antibody responses to PCEC on days 14 and 28. Three generalized reactions probably related to EARS were the only serious side effects. An eight-site i.d. PCEC vaccine regimen proved as immunogenic as the routine i.m. schedule and, if implemented as post-exposure prophylaxis, would be the cheapest widely available tissue culture vaccine regimen. The protective efficiency should now be tested in patients bitten by rabid animals.

scholarly journals Clinical evaluation of purified chick embryo cell rabies vaccine administered intradermally in animal exposures

2018 ◽  
Vol 5 (2) ◽  
pp. 585
Author(s):  
Ravish S. Hardanahalli ◽  
Veena V. ◽  
Ramesh Holla ◽  
Rachana R. Annadani ◽  
Sathish Chandra M. R.
Keyword(s):  
Cell Culture ◽  
Chick Embryo ◽  
Adverse Drug Events ◽  
Neutralizing Antibody ◽  
Embryo Cell ◽  
Human Rabies ◽  
Post Exposure Prophylaxis ◽  
Post Exposure ◽  
Chick Embryo Cell ◽  
Exposure Prophylaxis

Background: In India, presently there are two purified chick embryo cell culture vaccines (PCECV) viz., Rabipur (Flury LEP strain) and Vaxirab – N (Pitman Moore strain) which are commonly used both in public as well as private sectors. The present study was conducted to assess the clinical efficacy in terms of safety, immunogenicity and survival status of both the PCECV administered animal exposures taking complete PEP at the anti-rabies clinic.Methods: A longitudinal study was conducted at the anti-rabies clinic, Kempegowda Institute of Medical Sciences (KIMS), Bangalore, India. 86 suspect rabid dog bite cases attending clinic were enrolled and followed up for 1year. All the animal bite cases were given post exposure prophylaxis of full course of PCECV i.e. Rabipur or Vaxirab - N as per schedule intradermally using updated Thai Red Cross regimen. The rabies virus neutralizing antibody (RVNA) concentrations on days 14, 28, 90, and 180 were tested by modified rapid fluores­cent focus inhibition test.Results: Out of 86 study subjects, 43 subjects received Rabipur and another 43 subjects received Vaxirab –N vaccines. The incidence of adverse drug events (ADEs) was found to be 9.3%. All subjects had protective RVNA titers of ³0.5 IU/ml from day 14 till day 180. All the study subjects were healthy and alive after 6 months of completing PEP.Conclusions: The currently available purified chick embryo cell culture rabies vaccines are safe, immunogenic and clinically effective for post exposure prophylaxis in animal bite cases, which will help in eliminating human rabies by 2020. 

A comparative study on the safety and immunogenicity of purified duck embryo cell vaccine (PDEV, Vaxirab) with purified chick embryo cell vaccine (PCEC, Rabipur) and purifed vero cell rabies vaccine (PVRV, Verorab)

Vaccine ◽  
2009 ◽  
Vol 28 (1) ◽  
pp. 148-151 ◽  
Author(s):  
Doddabele Hanumantaiah Ashwathnarayana ◽  
Shampur Narayana Madhusudana ◽  
Gadey Sampath ◽  
Durga Madhab Sathpathy ◽  
Ranjit Mankeshwar ◽  
...  
Keyword(s):  
Chick Embryo ◽  
Comparative Study ◽  
Vero Cell ◽  
Embryo Cell ◽  
Rabies Vaccine ◽  
Cell Vaccine ◽  
Duck Embryo ◽  
Chick Embryo Cell

A randomized non-inferiority clinical study to assess post-exposure prophylaxis by a new purified vero cell rabies vaccine (Rabivax-S) administered by intramuscular and intradermal routes

Vaccine ◽  
2016 ◽  
Vol 34 (40) ◽  
pp. 4820-4826 ◽  
Author(s):  
Anuradha Bose ◽  
Renuka Munshi ◽  
Radha Madhab Tripathy ◽  
Shampur N. Madhusudana ◽  
B.R. Harish ◽  
...  
Keyword(s):  
Clinical Study ◽  
Vero Cell ◽  
Rabies Vaccine ◽  
Post Exposure Prophylaxis ◽  
Post Exposure ◽  
Exposure Prophylaxis

Protecting Indian schoolchildren against rabies: Pre-exposure vaccination with purified chick embryo cell vaccine (PCECV) or purified verocell rabies vaccine (PVRV)

2008 ◽  
Vol 4 (5) ◽  
pp. 365-369 ◽  
Author(s):  
Preeti Shanbag ◽  
Nitin Shah ◽  
Madhuri Kulkarni ◽  
Manisha Juvekar ◽  
Shampur N. Madhusudana ◽  
...  
Keyword(s):  
Chick Embryo ◽  
Embryo Cell ◽  
Rabies Vaccine ◽  
Cell Vaccine ◽  
Chick Embryo Cell
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