scholarly journals Clinical evaluation of purified chick embryo cell rabies vaccine administered intradermally in animal exposures

2018 ◽  
Vol 5 (2) ◽  
pp. 585
Author(s):  
Ravish S. Hardanahalli ◽  
Veena V. ◽  
Ramesh Holla ◽  
Rachana R. Annadani ◽  
Sathish Chandra M. R.
Keyword(s):  
Cell Culture ◽  
Chick Embryo ◽  
Adverse Drug Events ◽  
Neutralizing Antibody ◽  
Embryo Cell ◽  
Human Rabies ◽  
Post Exposure Prophylaxis ◽  
Post Exposure ◽  
Chick Embryo Cell ◽  
Exposure Prophylaxis

Background: In India, presently there are two purified chick embryo cell culture vaccines (PCECV) viz., Rabipur (Flury LEP strain) and Vaxirab – N (Pitman Moore strain) which are commonly used both in public as well as private sectors. The present study was conducted to assess the clinical efficacy in terms of safety, immunogenicity and survival status of both the PCECV administered animal exposures taking complete PEP at the anti-rabies clinic.Methods: A longitudinal study was conducted at the anti-rabies clinic, Kempegowda Institute of Medical Sciences (KIMS), Bangalore, India. 86 suspect rabid dog bite cases attending clinic were enrolled and followed up for 1year. All the animal bite cases were given post exposure prophylaxis of full course of PCECV i.e. Rabipur or Vaxirab - N as per schedule intradermally using updated Thai Red Cross regimen. The rabies virus neutralizing antibody (RVNA) concentrations on days 14, 28, 90, and 180 were tested by modified rapid fluores­cent focus inhibition test.Results: Out of 86 study subjects, 43 subjects received Rabipur and another 43 subjects received Vaxirab –N vaccines. The incidence of adverse drug events (ADEs) was found to be 9.3%. All subjects had protective RVNA titers of ³0.5 IU/ml from day 14 till day 180. All the study subjects were healthy and alive after 6 months of completing PEP.Conclusions: The currently available purified chick embryo cell culture rabies vaccines are safe, immunogenic and clinically effective for post exposure prophylaxis in animal bite cases, which will help in eliminating human rabies by 2020. 

scholarly journals Purified chick embryo cell rabies vaccine: economical multisite intradermal regimen for post-exposure prophylaxis

1987 ◽  
Vol 99 (3) ◽  
pp. 755-765 ◽  
Author(s):  
Pravan Suntharasamai ◽  
M. J. Warrell ◽  
Chaisin Viravan ◽  
Pornthep Chanthavanich ◽  
Sornchai Looareesuwan ◽  
...  
Keyword(s):  
Chick Embryo ◽  
Embryo Cell ◽  
Rabies Vaccine ◽  
Human Rabies ◽  
Post Exposure Prophylaxis ◽  
Protective Efficiency ◽  
Vaccine Regimen ◽  
Post Exposure ◽  
Chick Embryo Cell ◽  
Exposure Prophylaxis

SUMMARYThe standard six-dose intramuscular (i.m.) rabies post-exposure vaccine regimen using a new purified chick embryo cell (PCEC) vaccine was compared with two economical multisite intradermal (i.d.) PCEC regimens, a multisite i.m. PCEC schedule and a subcutaneous regimen using a suckling mouse brain (SMB) rabies vaccine manufactured in Thailand. The neutralizing antibody results for the four-site and eight-site i.d. and the standard i.m. PCEC regimens were similar over 3 months. A three-site i.m. PCEC regimen had no advantage. The SMB vaccine gave the lowest antibody levels. Human rabies immune globulin therapy significantly increased the GMT of all groups on day 7, unlike equine antirabies serum (EARS). Both antisera suppressed antibody responses to PCEC on days 14 and 28. Three generalized reactions probably related to EARS were the only serious side effects. An eight-site i.d. PCEC vaccine regimen proved as immunogenic as the routine i.m. schedule and, if implemented as post-exposure prophylaxis, would be the cheapest widely available tissue culture vaccine regimen. The protective efficiency should now be tested in patients bitten by rabid animals.

scholarly journals Safety and Immunogenicity of purified chick embryo cell rabies vaccine (VaxiRab N) administered intradermally as post exposure prophylaxis

2014 ◽  
Vol 10 (8) ◽  
pp. 2433-2437 ◽  
Author(s):  
Hardanahalli S Ravish ◽  
Veena Vijayashankar ◽  
Shampur N Madhusudana ◽  
Mysore K Sudarshan ◽  
Doddabele HA Narayana ◽  
...  
Keyword(s):  
Chick Embryo ◽  
Embryo Cell ◽  
Rabies Vaccine ◽  
Post Exposure Prophylaxis ◽  
Post Exposure ◽  
Chick Embryo Cell ◽  
Exposure Prophylaxis

scholarly journals In Vivo Efficacy of SYN023, an Anti-Rabies Monoclonal Antibody Cocktail, in Post-Exposure Prophylaxis Animal Models

2020 ◽  
Vol 5 (1) ◽  
pp. 31 ◽  
Author(s):  
Tzu-Yuan Chao ◽  
Shou-feng Zhang ◽  
Li Chen ◽  
Eric Tsao ◽  
Charles E. Rupprecht
Keyword(s):  
Animal Models ◽  
Standard Dose ◽  
Neutralizing Antibody ◽  
Cost Effective ◽  
Human Rabies ◽  
Post Exposure Prophylaxis ◽  
Vaccine Response ◽  
Post Exposure ◽  
Exposure Prophylaxis

Rabies immune globulin (RIG) is an indispensable component of rabies post-exposure prophylaxis (PEP) because it provides passive immunity to prevent this otherwise inescapably fatal disease in Category III exposed patients. Even with decades of development, RIG products are still criticized for their high cost, lot-to-lot variation, and potential safety issues. They remain largely unattainable in most developing regions of the world, where demand is highest. In recent years, monoclonal antibodies (MAbs) have become widely accepted as safer and more cost-effective alternatives to RIG products. As an example, SYN023 is a 1:1 cocktail of two humanized anti-rabies MAbs previously shown to display extensive neutralizing capabilities. Here, we further assessed the efficacy of SYN023 in animal models of rabies, and found that SYN023 afforded protection equal to a standard dose of human RIG (HRIG) at 0.03 mg/kg in Syrian hamsters and 0.1 mg/kg in beagles. Potential interference with vaccine-induced immunity was analyzed for the MAbs at these concentrations. While individual MAbs did not interfere with vaccine response, SYN023 at dosages of 0.1 mg/kg and above resulted in reduced neutralizing antibody titers similar to HRIG. Thus, the in vivo characterization of SYN023 supports its utility in human rabies PEP as an efficacious alternative to RIG products.

Antibodies induced by vaccination with purified chick embryo cell culture vaccine (PCECV) cross-neutralize non-classical bat lyssavirus strains

Vaccine ◽  
2009 ◽  
Vol 27 (39) ◽  
pp. 5320-5325 ◽  
Author(s):  
Claudius Malerczyk ◽  
Thomas Selhorst ◽  
Noël Tordo ◽  
Susan Moore ◽  
Thomas Müller
Keyword(s):  
Cell Culture ◽  
Chick Embryo ◽  
Embryo Cell ◽  
Chick Embryo Cell
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