scholarly journals Lack of effectiveness of 13-valent pneumococcal conjugate vaccination against pneumococcal carriage density in Papua New Guinean infants

Vaccine ◽  
2021 ◽  
Author(s):  
Kathryn J. Britton ◽  
Janessa L. Pickering ◽  
William S. Pomat ◽  
Camilla de Gier ◽  
Monica L. Nation ◽  
...  
Keyword(s):  
Pneumococcal Carriage ◽  
Conjugate Vaccination ◽  
Papua New Guinean

scholarly journals Safety and Immunogenicity of Neonatal Pneumococcal Conjugate Vaccination in Papua New Guinean Children: A Randomised Controlled Trial

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56698 ◽  
Author(s):  
William S. Pomat ◽  
Anita H. J. van den Biggelaar ◽  
Suparat Phuanukoonnon ◽  
Jacinta Francis ◽  
Peter Jacoby ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
Randomised Controlled ◽  
Conjugate Vaccination ◽  
Papua New Guinean

scholarly journals Predictors of pneumococcal carriage and the effect of the 13-valent pneumococcal conjugate vaccination in the Western Australian Aboriginal population

Pneumonia ◽  
2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Deirdre A. Collins ◽  
Anke Hoskins ◽  
Thomas Snelling ◽  
Kalpani Senasinghe ◽  
Jacinta Bowman ◽  
...  
Keyword(s):  
Aboriginal Population ◽  
Australian Aboriginal ◽  
Pneumococcal Carriage ◽  
Conjugate Vaccination ◽  
Western Australian

scholarly journals Impact of a Pneumococcal Conjugate Vaccination Program on Carriage among Children in Norway

2010 ◽  
Vol 17 (3) ◽  
pp. 325-334 ◽  
Author(s):  
Didrik F. Vestrheim ◽  
E. Arne Høiby ◽  
Ingeborg S. Aaberge ◽  
Dominique A. Caugant
Keyword(s):  
Dose Schedule ◽  
Drug Susceptibility ◽  
Drug Susceptibility Testing ◽  
Nasopharyngeal Colonization ◽  
Day Care Centers ◽  
Prevalence Studies ◽  
Vaccine Introduction ◽  
Pneumococcal Carriage ◽  
Boost Dose ◽  
Conjugate Vaccination

ABSTRACT In July 2006, the seven-valent pneumococcal conjugate vaccine (PCV7) was introduced in Norway with a reduced (2 doses + 1 boost) dose schedule. Post-PCV7 shifts in pneumococcal reservoirs were assessed by two point prevalence studies of nasopharyngeal colonization among children in day care centers, before (2006) and after (2008) widespread use of PCV7. Nasopharyngeal swabs were obtained from 1,213 children, 611 in 2006 and 602 in 2008. A total of 1,102 pneumococcal isolates were recovered. Serotyping, multilocus sequence typing, and antimicrobial drug susceptibility testing were performed on all isolates. Although carriage of PCV7 serotypes decreased among both vaccinated and unvaccinated children, the overall prevalence of pneumococcal carriage remained high (80.4%) after vaccine introduction. The pneumococcal populations were diverse, and in the shift toward non-PCV7 serotypes, expansion of a limited number of established clonal complexes was observed. While non-antimicrobial-susceptible clones persisted among PCV7 serotypes, antimicrobial resistance did not increase among non-PCV7 serotypes. Direct and indirect protection of PCV7 against nasopharyngeal colonization was inferred from an overall decrease in carriage of PCV7 serotypes. No preference was found for nonsusceptible clones among the replacing non-PCV7 serotypes.

scholarly journals Age-Specific Cluster of Cases of Serotype 1 Streptococcus pneumoniae Carriage in Remote Indigenous Communities in Australia

2009 ◽  
Vol 16 (2) ◽  
pp. 218-221 ◽  
Author(s):  
H. Smith-Vaughan ◽  
R. Marsh ◽  
G. Mackenzie ◽  
J. Fisher ◽  
P. S. Morris ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Pneumococcal Disease ◽  
Indigenous Communities ◽  
Northern Territory ◽  
Pneumococcal Serotypes ◽  
Apparent Increase ◽  
Pneumococcal Carriage ◽  
Serotype 1 ◽  
Conjugate Vaccination ◽  
Specific Cluster

ABSTRACT Seven-valent pneumococcal conjugate vaccination commenced in 2001 for Australian indigenous infants. Pneumococcal carriage surveillance detected substantial replacement with nonvaccine serotypes and a cluster of serotype 1 carriage. Our aim was to review Streptococcus pneumoniae serotype 1 carriage and invasive pneumococcal disease (IPD) data for this population and to analyze serotype 1 isolates. Carriage data were collected between 1992 and 2004 in the Darwin region, one of the five regions in the Northern Territory. Carriage data were also collected in 2003 and 2005 from four regions in the Northern Territory. Twenty-six cases of serotype 1 IPD were reported from 1994 to 2007 in the Northern Territory. Forty-four isolates were analyzed by BOX typing and 11 by multilocus sequence typing. In the Darwin region, 26 children were reported carrying serotype 1 (ST227) in 2002 but not during later surveillance. Scattered cases of serotype 1 carriage were noted in two other regions. Cocolonization of serotype 1 with other pneumococcal serotypes was common (34% serotype 1-positive swabs). In conclusion, pneumococcal carriage studies detected intermittent serotype 1 carriage and an ST227 cluster in children in indigenous communities in the Northern Territory of Australia. There was no apparent increase in serotype 1 IPD during this time. The rate of serotype 1 cocolonization with other pneumococcal serotypes suggests that carriage of this serotype may be underestimated.

scholarly journals Pneumococcal carriage in households in Karonga District, Malawi, before and after introduction of 13-valent pneumococcal conjugate vaccination

Vaccine ◽  
2018 ◽  
Vol 36 (48) ◽  
pp. 7369-7376 ◽  
Author(s):  
Ellen Heinsbroek ◽  
Terence Tafatatha ◽  
Amos Phiri ◽  
Todd D Swarthout ◽  
Maaike Alaerts ◽  
...  
Keyword(s):  
Pneumococcal Carriage ◽  
Before And After ◽  
Conjugate Vaccination
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