Dynamics of drug binding to the hERG channel: An in silico cardiac action potential model for early safety assessment

2012 ◽  
Vol 66 (2) ◽  
pp. 171
Author(s):  
Giovanni Y. Di Veroli ◽  
Mark Davies ◽  
Chris E. Pollard ◽  
Jean-Pierre Valentin ◽  
Henggui Zhang ◽  
...  
Keyword(s):  
Action Potential ◽  
In Silico ◽  
Safety Assessment ◽  
Potential Model ◽  
Drug Binding ◽  
Herg Channel ◽  
Cardiac Action Potential ◽  
Cardiac Action

scholarly journals SIMULATION RELIABILITY OF PHYSIOLOGICAL PHENOMENA BY CARDIAC ACTION POTENTIAL MODEL

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Ching‐Hsing Luo ◽  
Po‐Yuan Chen ◽  
Chun‐Hao Teng ◽  
Ching‐Ting Lee ◽  
Ruey‐Jen Sung
Keyword(s):  
Action Potential ◽  
Potential Model ◽  
Cardiac Action Potential ◽  
Cardiac Action

Local Onset of Voltage and Calcium Alternans in the Heart

2011 ◽  
Author(s):  
Stephen D. McIntyre ◽  
Yoichiro Mori ◽  
Elena G. Tolkacheva
Keyword(s):  
Ventricular Fibrillation ◽  
Action Potential ◽  
Intracellular Calcium ◽  
Cardiac Myocytes ◽  
Cardiac Tissue ◽  
Potential Model ◽  
Cardiac Action Potential ◽  
2D Simulation ◽  
Cardiac Action ◽  
Electrical Alternans

A beat-to-beat variation in cardiac action potential durations (APD) is a phenomenon known as electrical alternans. Alternans desynchronizes depolarization, increases dispersion of refractoriness and creates a substrate for ventricular fibrillation. In the heart, APD alternans can be accompanied by alternans in intracellular calcium ([Ca2+]i) transients. Recently, we demonstrated experimentally that the onset of APD alternans in the heart is a local phenomenon that undergoes complex spatiotemporal dynamics as pacing rate increases. Moreover, the local onset of APD alternans can be predicted by measuring the restitution properties of periodically paced cardiac tissue. The purpose of this research is to investigate the interplay between local onsets of APD and [Ca2+]i alternans using 2D simulation of action potential model of cardiac myocytes.

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