Reliable identification of heart disease in drug discovery using automated patch clamps: Benchmarking best practices and calibration criteria for improved proarrhythmic assessment

2021 ◽  
Vol 111 ◽  
pp. 106963
Author(s):  
Masafumi Doi ◽  
Nina Brinkwirth ◽  
Kiyoshi Takasuna ◽  
Nadine Becker ◽  
Alison Obergrussberger ◽  
...  
Keyword(s):  
Heart Disease ◽  
Drug Discovery ◽  
Best Practices ◽  
Patch Clamps ◽  
Reliable Identification

A DRUG DISCOVERY PLATAFORM FOR THE IDENTIFICATION OF NOVEL INFARCT SPARING AGENTS FOR TREATMENT OF ISCHEMIC HEART DISEASE

2016 ◽  
Vol 32 (10) ◽  
pp. S275-S276
Author(s):  
H. Aceros ◽  
S. Der Sarkissian ◽  
M. Borie ◽  
L. Stevens ◽  
S. Mansour ◽  
...  
Keyword(s):  
Heart Disease ◽  
Drug Discovery ◽  
Ischemic Heart Disease ◽  
Ischemic Heart

scholarly journals Reliable Identification of hERG Liability in Drug Discovery by Automated Patch Clamp

2020 ◽  
Vol 118 (3) ◽  
pp. 116a-117a
Author(s):  
Michael George ◽  
Rodolfo Haedo ◽  
Nina Brinkwirth ◽  
Nadine Becker ◽  
Claudia S. Haarmann ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Patch Clamp ◽  
Reliable Identification ◽  
Automated Patch Clamp

scholarly journals Phytochemical, Nutritional and Pharmacological evidences for Abelmoschus esculentus (L.)

2016 ◽  
Vol 5 (6) ◽  
pp. 238-241
Author(s):  
Rakesh K Sindhu ◽  
◽  
Vishal Puri ◽  
Keyword(s):  
Heart Disease ◽  
Drug Discovery ◽  
Neurological Disorders ◽  
Health Benefits ◽  
Scientific Research ◽  
Abelmoschus Esculentus ◽  
Pharmacological Properties ◽  
Good Source ◽  
New Drug ◽  
Nutritional Potential

Okra is a nutritional source of power used throughout history for both medicinal and culinary purposes. Okra is good source of minerals, vitamins and nutrients that are responsible for the health benefits. It has various reported pharmacological properties like antidabetic, antioxidant, nootropic, eye, heart disease and neurological disorders etc. This effort is towards providing the evidence in support to encourage more scientific research to find out more pharmacological and nutritional potential of Abelmoschus esculentus that may be suggestive of new drug discovery.

scholarly journals Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies

2011 ◽  
Vol 3 (5) ◽  
pp. 28 ◽  
Author(s):  
Diana W Shineman ◽  
Guriqbal S Basi ◽  
Jennifer L Bizon ◽  
Carol A Colton ◽  
Barry D Greenberg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Discovery ◽  
Best Practices ◽  
Animal Studies

scholarly journals Human Stem Cells for Modeling Heart Disease and for Drug Discovery

2014 ◽  
Vol 6 (239) ◽  
pp. 239ps6-239ps6 ◽  
Author(s):  
E. Matsa ◽  
P. W. Burridge ◽  
J. C. Wu
Keyword(s):  
Stem Cells ◽  
Heart Disease ◽  
Drug Discovery ◽  
Human Stem Cells

scholarly journals Alchemical Binding Free Energy Calculations in AMBER20: Advances and Best Practices for Drug Discovery

2020 ◽  
Vol 60 (11) ◽  
pp. 5595-5623 ◽  
Author(s):  
Tai-Sung Lee ◽  
Bryce K. Allen ◽  
Timothy J. Giese ◽  
Zhenyu Guo ◽  
Pengfei Li ◽  
...  
Keyword(s):  
Free Energy ◽  
Drug Discovery ◽  
Best Practices ◽  
Binding Free Energy ◽  
Free Energy Calculations ◽  
Energy Calculations ◽  
Binding Free Energy Calculations
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