Better compliance to antihypertensive medications reduces cardiovascular risk

2012 ◽  
Vol 2012 ◽  
pp. 55-57
Author(s):  
W.J. Elliott
Keyword(s):  
Cardiovascular Risk ◽  
Antihypertensive Medications

BETTER COMPLIANCE TO ANTIHYPERTENSIVE MEDICATIONS REDUCES CARDIOVASCULAR RISK

2011 ◽  
Vol 29 ◽  
pp. e122
Author(s):  
G. Mancia ◽  
A. Parodi ◽  
F. Nicotra ◽  
A. Zambon ◽  
L. Merlino ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Antihypertensive Medications

scholarly journals Bedtime Dosing of Antihypertensive Medications Reduces Cardiovascular Risk in CKD

2011 ◽  
Vol 22 (12) ◽  
pp. 2313-2321 ◽  
Author(s):  
Ramón C. Hermida ◽  
Diana E. Ayala ◽  
Artemio Mojón ◽  
José R. Fernández
Keyword(s):  
Cardiovascular Risk ◽  
Antihypertensive Medications

Better compliance to antihypertensive medications reduces cardiovascular risk

2011 ◽  
Vol 29 (3) ◽  
pp. 610-618 ◽  
Author(s):  
Giovanni Corrao ◽  
Andrea Parodi ◽  
Federica Nicotra ◽  
Antonella Zambon ◽  
Luca Merlino ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Antihypertensive Medications

scholarly journals Blood pressure in bipolar disorder: evidence of elevated pulse pressure and associations between mean pressure and mood instability

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Niall M. McGowan ◽  
Molly Nichols ◽  
Amy C. Bilderbeck ◽  
Guy M. Goodwin ◽  
Kate E. A. Saunders
Keyword(s):  
Blood Pressure ◽  
Bipolar Disorder ◽  
Cardiovascular Risk ◽  
Pulse Pressure ◽  
Blood Pressure Monitoring ◽  
Home Blood Pressure ◽  
Antihypertensive Medications ◽  
Negatively Associated ◽  
Mood Instability ◽  
Symptom Profile

Abstract Background Bipolar disorder (BD) is associated with excess and premature cardiovascular mortality. Elevated blood pressure (BP) is a leading contributor to cardiovascular risk. However, few studies have examined BP in BD in comparison to other psychiatric disorders. Furthermore, the association between BP and mood instability is not presently clear despite increasing interest in repurposing existing antihypertensive medications as possible novel BD treatments. Thus we examined BP differences between BD and borderline personality disorder (BPD), a disorder with a similar symptom profile through chronic mood instability. Methods A total of 106 adults (38 BD, 25 BPD, and 43 healthy controls), evaluated in the Automated Monitoring of Symptom Severity (AMoSS) study, completed a week-long home blood pressure monitoring assessment and ecological momentary assessment of mood. We examined group-wise differences in mean BP and BP variability and their association with mood instability. Results BD individuals had a significantly wider resting pulse pressure (40.8 ± 7.4, mmHg) compared to BPD (35.7 ± 5.3, mmHg, P = 0.03) and control participants (37.3 ± 6.3, mmHg, P = 0.036). Systolic BP was negatively associated with sad mood instability, and all measures of mean BP (systolic, diastolic, and mean arterial pressure) were negatively associated with positive mood instability. Conclusions This study demonstrates BP differences between BD and healthy and clinical controls that are within a normotensive range. Early pulse pressure widening may be a modifiable pathophysiological feature of BD that confers later cardiovascular risk. BP may be an important transdiagnostic predictor of mood instability and a potential explicit treatment target.

Pulse Pressure Inversely Correlates with Telomere Length in French Men

Hypertension ◽  
2000 ◽  
Vol 36 (suppl_1) ◽  
pp. 716-716
Author(s):  
Athanase Benetos ◽  
Koji Okuda ◽  
Malika Lajemi ◽  
Joan Skurnick ◽  
Carlos Labat ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Telomere Length ◽  
Pulse Pressure ◽  
Large Scale ◽  
Univariate Analysis ◽  
Biological Age ◽  
Chronological Age ◽  
Antihypertensive Medications ◽  
Men And Women ◽  
Telomere Attrition

P126 Cardiovascular risk increases with chronological age. Pulse pressure (PP) also increases with chronological age and is an independent indicator of cardiovascular risk. It is therefore possible that after age-adjustment, the biological age of persons with wide PP is more advanced than their chronological age would indicate. We explored whether an index of biological age, namely telomere length (measured by the mean length of the terminal restriction fragment, TRF), provides a better account than chronological age of about variation in PP. We studied 193 French men and women (age 56 ± 11 years) on no antihypertensive medications. Univariate analysis showed that in both genders, TRF length (in WBCs) was correlated inversely with age (p< 0.01). The rate of telomere attrition was 0.038 and 0.036 kb/year for men and women, respectively. Only in men, after adjustment for mean arterial pressure, TRF length accounted for 12% variability in PP (p<0.001), while chronological age accounted for 10% variability in PP (p<0.001). Age-adjusted TRF length was longer in women than men (8.67 ± 0.09 vs 8.38 ± 0.07 kb, p = 0.016). We conclude that TRF length adds additional information about variability in PP among men, such that men with shorter telomere length are more likely to exhibit a wider PP. The longer telomere length in women suggests that for a given chronological age, the biological age of men is more advanced than that of women. The results also underscore the sexual dimorphism in aging and blood pressure regulation. We propose that large-scale studies should be undertaken to explore the relation between telomere length and cardiovascular risk.

Abstract 14799: Home Blood Pressure Range and 24-hr Ambulatory Blood Pressure Control: The Japan Morning Surge Home Blood Pressure (J-HOP) Study-ABPM Substudy

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Mizuri Taki ◽  
Satoshi Hoshide ◽  
Kazuo Eguchi ◽  
Yuichiro Yano ◽  
Kazuomi Kario
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Ambulatory Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Pressure Control ◽  
Home Blood Pressure ◽  
High Cardiovascular Risk ◽  
Antihypertensive Medications ◽  
Data Memory ◽  
Blood Pressure Range

Background: Measures of home and ambulatory blood pressure monitoring (HBPM and ABPM) are crucial to evaluate BP control status in hypertensive patients. HBPM is widely used in clinical practice, but ABPM is used less frequently. Few studies have examined the threshold of home BP, suggesting well controlled BP in 24-hour BP, daytime BP, and nighttime BP . Methods: We analyzed data from the Japan Morning Surge Home Blood Pressure (J-HOP) Study, which included 1,439 patients with at least one cardiovascular risk factor (mean age 64.6 years, 47.8% men, 82.3% used antihypertensive medications). Both HBPM (three measures each in the morning and evening over 14 days, using the same semiautomatic HBP device with data memory and 24-hr ABPM were performed in all patients). Results: Of 355 patients with home systolic BP (HSBP) <125mmHg, 78.9%, 76.9%, and 81.4% were classified as having well-controlled 24-hr SBP (<130mmHg), daytime SBP (<135mmHg), and nighttime SBP (<120mmHg), respectively). In contrast, of 656 subjects with HSBP ≥135 mmHg, 67.5% were classified as having uncontrolled 24-hr SBP (≥130mm Hg). Of 428 patients with HSBP between 125mmHg and 134mmHg, only 54.9% were classified as having well-controlled 24-hr SBP. Conclusions: Among patients with high cardiovascular risk, nearly 80% of those with home systolic BP <125mmHg were well-controlled for 24-hr SBP including nighttime systolic BP, whereas nearly 70% of those with >135mmHg were uncontrolled for 24-hr systolic BP. The patients with HBP at 125-134mmHg require ABPM for the evaluation of their 24-hr BP control status.

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