scholarly journals Persistent expression of stabilized β-catenin delays maturation of radial glial cells into intermediate progenitors

2007 ◽  
Vol 309 (2) ◽  
pp. 285-297 ◽  
Author(s):  
Carolyn N. Wrobel ◽  
Christopher A. Mutch ◽  
Sruthi Swaminathan ◽  
Makoto M. Taketo ◽  
Anjen Chenn
Keyword(s):  
Glial Cells ◽  
Radial Glial Cells ◽  
Intermediate Progenitors ◽  
Radial Glial

scholarly journals Mind Bomb 1-Expressing Intermediate Progenitors Generate Notch Signaling to Maintain Radial Glial Cells

Neuron ◽  
2008 ◽  
Vol 58 (4) ◽  
pp. 519-531 ◽  
Author(s):  
Ki-Jun Yoon ◽  
Bon-Kyoung Koo ◽  
Sun-Kyoung Im ◽  
Hyun-Woo Jeong ◽  
Jaewang Ghim ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Glial Cells ◽  
Radial Glial Cells ◽  
Intermediate Progenitors ◽  
Radial Glial

scholarly journals Transcriptional priming as a conserved mechanism of lineage diversification in the developing mouse and human neocortex

2020 ◽  
Vol 6 (45) ◽  
pp. eabd2068
Author(s):  
Zhen Li ◽  
William A. Tyler ◽  
Ella Zeldich ◽  
Gabriel Santpere Baró ◽  
Mayumi Okamoto ◽  
...  
Keyword(s):  
Glial Cells ◽  
Radial Glia ◽  
Radial Glial Cells ◽  
Human Neocortex ◽  
Intermediate Progenitors ◽  
Cell Diversity ◽  
Radial Glial ◽  
The Rich ◽  
Lineage Diversification

How the rich variety of neurons in the nervous system arises from neural stem cells is not well understood. Using single-cell RNA-sequencing and in vivo confirmation, we uncover previously unrecognized neural stem and progenitor cell diversity within the fetal mouse and human neocortex, including multiple types of radial glia and intermediate progenitors. We also observed that transcriptional priming underlies the diversification of a subset of ventricular radial glial cells in both species; genetic fate mapping confirms that the primed radial glial cells generate specific types of basal progenitors and neurons. The different precursor lineages therefore diversify streams of cell production in the developing murine and human neocortex. These data show that transcriptional priming is likely a conserved mechanism of mammalian neural precursor lineage specialization.

scholarly journals Decoding Cortical Glial Cell Development

2021 ◽  
Author(s):  
Xiaosu Li ◽  
Guoping Liu ◽  
Lin Yang ◽  
Zhenmeiyu Li ◽  
Zhuangzhi Zhang ◽  
...  
Keyword(s):  
Single Cell ◽  
Glial Cell ◽  
Glial Cells ◽  
Cell Lineage ◽  
Gabaergic Interneurons ◽  
Rna Seq ◽  
Radial Glial Cells ◽  
Intermediate Progenitors ◽  
Late Embryogenesis ◽  
Radial Glial

AbstractMouse cortical radial glial cells (RGCs) are primary neural stem cells that give rise to cortical oligodendrocytes, astrocytes, and olfactory bulb (OB) GABAergic interneurons in late embryogenesis. There are fundamental gaps in understanding how these diverse cell subtypes are generated. Here, by combining single-cell RNA-Seq with intersectional lineage analyses, we show that beginning at around E16.5, neocortical RGCs start to generate ASCL1+EGFR+ apical multipotent intermediate progenitors (MIPCs), which then differentiate into basal MIPCs that express ASCL1, EGFR, OLIG2, and MKI67. These basal MIPCs undergo several rounds of divisions to generate most of the cortical oligodendrocytes and astrocytes and a subpopulation of OB interneurons. Finally, single-cell ATAC-Seq supported our model for the genetic logic underlying the specification and differentiation of cortical glial cells and OB interneurons. Taken together, this work reveals the process of cortical radial glial cell lineage progression and the developmental origins of cortical astrocytes and oligodendrocytes.

scholarly journals Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes

2021 ◽  
Author(s):  
Lin Yang ◽  
Zhenmeiyu Li ◽  
Guoping Liu ◽  
Xiaosu Li ◽  
Zhengang Yang
Keyword(s):  
Olfactory Bulb ◽  
Glial Cells ◽  
Pyramidal Neurons ◽  
Human Cortex ◽  
General Picture ◽  
Radial Glial Cells ◽  
Intermediate Progenitors ◽  
Molecular Features ◽  
Gestational Week ◽  
Radial Glial

AbstractHuman cortical radial glial cells are primary neural stem cells that give rise to cortical glutaminergic projection pyramidal neurons, glial cells (oligodendrocytes and astrocytes) and olfactory bulb GABAergic interneurons. One of prominent features of the human cortex is enriched with glial cells, but there are major gaps in understanding how these glial cells are generated. Herein, by integrating analysis of published human cortical single-cell RNA-Seq datasets with our immunohistochemistical analyses, we show that around gestational week 18, EGFR-expressing human cortical truncated radial glial cells (tRGs) give rise to basal multipotent intermediate progenitors (bMIPCs) that express EGFR, ASCL1, OLIG2 and OLIG1. These bMIPCs undergo several rounds of mitosis and generate cortical oligodendrocytes, astrocytes and olfactory bulb interneurons. We also characterized molecular features of the cortical tRG. Integration of our findings suggests a general picture of the lineage progression of cortical radial glial cells, a fundamental process of the developing human cerebral cortex.

scholarly journals Neuronal Regeneration from Ependymo-Radial Glial Cells: Cook, Little Pot, Cook!

2015 ◽  
Vol 32 (4) ◽  
pp. 516-527 ◽  
Author(s):  
Catherina G. Becker ◽  
Thomas Becker
Keyword(s):  
Glial Cells ◽  
Neuronal Regeneration ◽  
Radial Glial Cells ◽  
Radial Glial

Reelin and Radial Glial Cells

2008 ◽  
pp. 159-169
Author(s):  
Eckart Förster ◽  
Shanting Zhao ◽  
Michael Frotscher
Keyword(s):  
Glial Cells ◽  
Radial Glial Cells ◽  
Radial Glial

scholarly journals Radial glial cells as neuronal precursors: The next generation?

2002 ◽  
Vol 69 (6) ◽  
pp. 708-713 ◽  
Author(s):  
Christopher T. Gregg ◽  
Andrew K. Chojnacki ◽  
Samuel Weiss
Keyword(s):  
Glial Cells ◽  
Next Generation ◽  
Radial Glial Cells ◽  
Neuronal Precursors ◽  
Radial Glial
Sign in / Sign up

Export Citation Format

Share Document