scholarly journals Radial glial cells as neuronal precursors: The next generation?

2002 ◽  
Vol 69 (6) ◽  
pp. 708-713 ◽  
Author(s):  
Christopher T. Gregg ◽  
Andrew K. Chojnacki ◽  
Samuel Weiss
Keyword(s):  
Glial Cells ◽  
Next Generation ◽  
Radial Glial Cells ◽  
Neuronal Precursors ◽  
Radial Glial

scholarly journals EphA4 Regulates the Balance between Self-Renewal and Differentiation of Radial Glial Cells and Intermediate Neuronal Precursors in Cooperation with FGF Signaling

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0126942 ◽  
Author(s):  
Qingfa Chen ◽  
Daiki Arai ◽  
Kazuki Kawakami ◽  
Takahiro Sawada ◽  
Xuefeng Jing ◽  
...  
Keyword(s):  
Glial Cells ◽  
Fgf Signaling ◽  
Self Renewal ◽  
Radial Glial Cells ◽  
Neuronal Precursors ◽  
Radial Glial

Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage

Development ◽  
2000 ◽  
Vol 127 (24) ◽  
pp. 5253-5263 ◽  
Author(s):  
P. Malatesta ◽  
E. Hartfuss ◽  
M. Gotz
Keyword(s):  
Nervous System ◽  
Glial Cells ◽  
Cell Sorting ◽  
Cell Types ◽  
Cell Type ◽  
Radial Glial Cells ◽  
Neuronal Precursors ◽  
Neuronal Lineage ◽  
Radial Glial ◽  
Glial Lineage

The developing central nervous system of vertebrates contains an abundant cell type designated radial glial cells. These cells are known as guiding cables for migrating neurons, while their role as precursor cells is less clear. Since radial glial cells express a variety of astroglial characteristics and differentiate as astrocytes after completing their guidance function, they have been considered as part of the glial lineage. Using fluorescence-activated cell sorting, we show here that radial glial cells also are neuronal precursors and only later, after neurogenesis, do they shift towards an exclusive generation of astrocytes. These results thus demonstrate a novel function for radial glial cells, namely their ability to generate two major cell types found in the nervous system, neurons and astrocytes.

scholarly journals Neuronal Regeneration from Ependymo-Radial Glial Cells: Cook, Little Pot, Cook!

2015 ◽  
Vol 32 (4) ◽  
pp. 516-527 ◽  
Author(s):  
Catherina G. Becker ◽  
Thomas Becker
Keyword(s):  
Glial Cells ◽  
Neuronal Regeneration ◽  
Radial Glial Cells ◽  
Radial Glial

Reelin and Radial Glial Cells

2008 ◽  
pp. 159-169
Author(s):  
Eckart Förster ◽  
Shanting Zhao ◽  
Michael Frotscher
Keyword(s):  
Glial Cells ◽  
Radial Glial Cells ◽  
Radial Glial

scholarly journals Metabolic regulation and glucose sensitivity of cortical radial glial cells

2018 ◽  
Vol 115 (40) ◽  
pp. 10142-10147 ◽  
Author(s):  
Brian G. Rash ◽  
Nicola Micali ◽  
Anita J. Huttner ◽  
Yury M. Morozov ◽  
Tamas L. Horvath ◽  
...  
Keyword(s):  
Glial Cells ◽  
Metabolic Regulation ◽  
Physiological Mechanism ◽  
Metabolic Disturbances ◽  
Mitochondrial Transport ◽  
Radial Glial Cells ◽  
Intracellular Ca ◽  
Glucose Sensitivity ◽  
Radial Glial ◽  
Primary Stem

The primary stem cells of the cerebral cortex are the radial glial cells (RGCs), and disturbances in their operation lead to myriad brain disorders in all mammals from mice to humans. Here, we found in mice that maternal gestational obesity and hyperglycemia can impair the maturation of RGC fibers and delay cortical neurogenesis. To investigate potential mechanisms, we used optogenetic live-imaging approaches in embryonic cortical slices. We found that Ca2+signaling regulates mitochondrial transport and is crucial for metabolic support in RGC fibers. Cyclic intracellular Ca2+discharge from localized RGC fiber segments detains passing mitochondria and ensures their proper distribution and enrichment at specific sites such as endfeet. Impairment of mitochondrial function caused an acute loss of Ca2+signaling, while hyperglycemia decreased Ca2+activity and impaired mitochondrial transport, leading to degradation of the RGC scaffold. Our findings uncover a physiological mechanism indicating pathways by which gestational metabolic disturbances can interfere with brain development.

Radial Glial Cells

2013 ◽  
Author(s):  
Magdalena Götz
Keyword(s):  
Glial Cells ◽  
Topic Area ◽  
Radial Glial Cells ◽  
Radial Glial ◽  
Digitally Enhanced

This is a digitally enhanced text. Readers can also see the coverage of this topic area in the second edition of Neuroglia. The second edition of Neuroglia was first published digitally in Oxford Scholarship Online and the bibliographic details provided, if cited, will direct people to that version of the text. Readers can also see the coverage of this topic area in the ...

Sign in / Sign up

Export Citation Format

Share Document