scholarly journals Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defect

2014 ◽  
Vol 391 (2) ◽  
pp. 170-181 ◽  
Author(s):  
Fenglei He ◽  
Xuefeng Hu ◽  
Wei Xiong ◽  
Lu Li ◽  
Lisong Lin ◽  
...  
Keyword(s):  
Neural Crest ◽  
Birth Defect ◽  
Genetic Model ◽  
Neural Crest Cells ◽  
Bmp4 Expression ◽  
Human Bony

Bimodal functions of Notch-mediated signaling are involved in neural crest formation during avian ectoderm development

Development ◽  
2002 ◽  
Vol 129 (4) ◽  
pp. 863-873 ◽  
Author(s):  
Yukinori Endo ◽  
Noriko Osumi ◽  
Yoshio Wakamatsu
Keyword(s):  
Neural Crest ◽  
Plate Boundary ◽  
Neural Crest Cells ◽  
Neural Plate ◽  
Mutual Interaction ◽  
Notch Ligand ◽  
Bmp4 Expression ◽  
Notch Activation

Neural crest is induced at the junction of epidermal ectoderm and neural plate by the mutual interaction of these tissues. In previous studies, BMP4 has been shown to pattern the ectodermal tissues, and BMP4 can induce neural crest cells from the neural plate. In this study, we show that epidermally expressed Delta1, which encodes a Notch ligand, is required for the activation and/or maintenance of Bmp4 expression in this tissue, and is thus indirectly required for neural crest induction by BMP4 at the epidermis-neural plate boundary. Notch activation in the epidermis additionally inhibits neural crest formation in this tissue, so that neural crest generation by BMP4 is restricted to the junction.

The WNT antagonist cSFRP2 modulates programmed cell death in the developing hindbrain

Development ◽  
2000 ◽  
Vol 127 (24) ◽  
pp. 5285-5295 ◽  
Author(s):  
D.L. Ellies ◽  
V. Church ◽  
P. Francis-West ◽  
A. Lumsden
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Neural Crest ◽  
Neural Crest Cells ◽  
Over Expression ◽  
Bmp4 Expression ◽  
Bmp Signalling

In the avian hindbrain, the loss of premigratory neural crest cells from rhombomeres 3 and 5 (r3, r5) through programmed cell death contributes to the patterning of emigrant crest cells into three discrete streams. Programmed cell death is induced by the upregulation of Bmp4 and Msx2 in r3 and r5. We show that cSFRP2, a WNT antagonist, is expressed in the even-numbered rhombomeres and that over-expression of cSfrp2 inhibits Bmp4 expression in r3 and r5, preventing programmed cell death. By contrast, depleting cSFRP2 function in r4 results in elevated levels of Msx2 expression and ectopic programmed cell death, as does overexpression of Wnt1. We propose that programmed cell death in the rhombencephalic neural crest is modulated by pre-patterned cSfrp2 expression and a WNT-BMP signalling loop.

Induction of melanocyte precursors from neural crest cells surrounding the neural tube-like structures developed in vitro using mouse ES cell culture

2007 ◽  
Vol 27 (1) ◽  
pp. 45-52
Author(s):  
Koh-ichi Atoh ◽  
Manae S. Kurokawa ◽  
Hideshi Yoshikawa ◽  
Chieko Masuda ◽  
Erika Takada ◽  
...  
Keyword(s):  
Cell Culture ◽  
Neural Crest ◽  
Neural Tube ◽  
Neural Crest Cells ◽  
Es Cell ◽  
Mouse Es Cell

Migratory Neural Crest Cells Phagocytose Cellular Debris in the Developing Nervous System

2019 ◽  
Author(s):  
Yunlu Zhu ◽  
Samantha C. Crowley ◽  
Andrew J. Latimer ◽  
Gwendolyn M. Lewis ◽  
Rebecca Nash ◽  
...  
Keyword(s):  
Nervous System ◽  
Neural Crest ◽  
Neural Crest Cells ◽  
Cellular Debris ◽  
Developing Nervous System
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