scholarly journals Diverse ETS transcription factors mediate FGF signaling in the Ciona anterior neural plate

2015 ◽  
Vol 399 (2) ◽  
pp. 218-225 ◽  
Author(s):  
T. Blair Gainous ◽  
Eileen Wagner ◽  
Michael Levine
Keyword(s):  
Transcription Factors ◽  
Neural Plate ◽  
Fgf Signaling ◽  
Ets Transcription Factors ◽  
Anterior Neural Plate

scholarly journals Loss of Fgf-responsive Pea3 transcription factors results in ciliopathy-associated phenotypes during early zebrafish development

2020 ◽  
Author(s):  
Matt E. McFaul ◽  
Neta Hart ◽  
Bruce W. Draper
Keyword(s):  
Signal Transduction ◽  
Transcription Factors ◽  
Body Axis ◽  
Fgf Signaling ◽  
Ets Transcription Factors ◽  
Mesoderm Development ◽  
Curly Tail ◽  
Positive Regulators ◽  
Summary Statement ◽  
Intracellular Response

AbstractFGF signaling is used reiteratively during development and elicits several different responses, such as cell proliferation, differentiation, or migration. We parsed the complex FGF intracellular response by creating triple homozygous mutants in the Pea3 subgroup of ETS transcription factors, designated 3etv mutants. The Pea3 proteins Etv4 and Etv5 are expressed in areas of FGF activity; however, their role in FGF signal transduction as either positive or negative modulators of FGF activity was unclear. Using 3etv mutants, we found these genes act redundantly and have phenotypes consistent with known FGF defects in inner ear, pectoral fin, and posterior mesoderm development. Additionally, we uncovered a novel role for the FGF/Pea3 pathway during body axis straightening. 3etv larvae develop a curly-tail up (CTU) phenotype that we linked to mis-regulation of the polycystin and urotensin pathways, which have opposing actions to ensure a straight body orientation along the dorsal-ventral axis. We find that the Etv4/5 transcription factors act as positive regulators of FGF signaling and propose a model where Etv4/5 are required for cilia function downstream of Fgf8a.Summary StatementPea3 transcription factor triple mutants reveal a role for FGF signaling in balancing polycystin and urotensin signaling to achieve a straight body axis.

scholarly journals Overlapping functions of Pea3 ETS transcription factors in FGF signaling during zebrafish development

2010 ◽  
Vol 342 (1) ◽  
pp. 11-25 ◽  
Author(s):  
Wade A. Znosko ◽  
Shibin Yu ◽  
Kirk Thomas ◽  
Gabriela A. Molina ◽  
Chengjian Li ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Fgf Signaling ◽  
Ets Transcription Factors ◽  
Zebrafish Development

scholarly journals Hallmarks of primary neurulation are conserved in the zebrafish forebrain

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Jonathan M. Werner ◽  
Maraki Y. Negesse ◽  
Dominique L. Brooks ◽  
Allyson R. Caldwell ◽  
Jafira M. Johnson ◽  
...  
Keyword(s):  
Neural Tube ◽  
Time Lapse ◽  
Neural Plate ◽  
Neural Tube Closure ◽  
Developmental Studies ◽  
Underlying Causes ◽  
The Central Nervous System ◽  
Resolution Imaging ◽  
Fold Formation ◽  
Anterior Neural Plate

AbstractPrimary neurulation is the process by which the neural tube, the central nervous system precursor, is formed from the neural plate. Incomplete neural tube closure occurs frequently, yet underlying causes remain poorly understood. Developmental studies in amniotes and amphibians have identified hingepoint and neural fold formation as key morphogenetic events and hallmarks of primary neurulation, the disruption of which causes neural tube defects. In contrast, the mode of neurulation in teleosts has remained highly debated. Teleosts are thought to have evolved a unique mode of neurulation, whereby the neural plate infolds in absence of hingepoints and neural folds, at least in the hindbrain/trunk where it has been studied. Using high-resolution imaging and time-lapse microscopy, we show here the presence of these morphological landmarks in the zebrafish anterior neural plate. These results reveal similarities between neurulation in teleosts and other vertebrates and hence the suitability of zebrafish to understand human neurulation.

scholarly journals A gene regulatory network that underlies the derivation of the anterior neural plate from the epiblast

2010 ◽  
Vol 344 (1) ◽  
pp. 495
Author(s):  
Makiko Iwafuchi-Doi ◽  
Tatsuya Takemoto ◽  
Yuzo Yoshida ◽  
Isao Matsuo ◽  
Jun Aruga ◽  
...  
Keyword(s):  
Gene Regulatory Network ◽  
Regulatory Network ◽  
Neural Plate ◽  
Gene Regulatory ◽  
Anterior Neural Plate

FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain

Development ◽  
2002 ◽  
Vol 129 (16) ◽  
pp. 3825-3837 ◽  
Author(s):  
Lisa Maves ◽  
William Jackman ◽  
Charles B. Kimmel
Keyword(s):  
Neuronal Differentiation ◽  
Crucial Role ◽  
Time Lapse ◽  
Signaling Molecules ◽  
Neural Plate ◽  
Fgf Signaling ◽  
Genetic Mosaic ◽  
Signaling Center ◽  
Signaling Activity ◽  
Rhombomere 4

The segmentation of the vertebrate hindbrain into rhombomeres is highly conserved, but how early hindbrain patterning is established is not well understood. We show that rhombomere 4 (r4) functions as an early-differentiating signaling center in the zebrafish hindbrain. Time-lapse analyses of zebrafish hindbrain development show that r4 forms first and hindbrain neuronal differentiation occurs first in r4. Two signaling molecules, FGF3 and FGF8, which are both expressed early in r4, are together required for the development of rhombomeres adjacent to r4, particularly r5 and r6. Transplantation of r4 cells can induce expression of r5/r6 markers, as can misexpression of either FGF3 or FGF8. Genetic mosaic analyses also support a role for FGF signaling acting from r4. Taken together, our findings demonstrate a crucial role for FGF-mediated inter-rhombomere signaling in promoting early hindbrain patterning and underscore the significance of organizing centers in patterning the vertebrate neural plate.

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