E-liquids and vanillin flavoring disrupts retinoic acid signaling and causes craniofacial defects in Xenopus embryos.

2021 ◽  
Author(s):  
Amanda J.G. Dickinson ◽  
Stephen D. Turner ◽  
Stacey Wahl ◽  
Allyson E. Kennedy ◽  
Brent H. Wyatt ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Signaling ◽  
Xenopus Embryos ◽  
Craniofacial Defects

scholarly journals GABAergic differentiation in the basal ganglia requires retinoic acid signaling

2011 ◽  
Vol 356 (1) ◽  
pp. 181
Author(s):  
Christina Chatzi ◽  
Thomas Brade ◽  
Gregg Duester
Keyword(s):  
Retinoic Acid ◽  
Basal Ganglia ◽  
Retinoic Acid Signaling

scholarly journals Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling

2017 ◽  
Vol 37 (10) ◽  
pp. 2565-2579 ◽  
Author(s):  
Jonathan J. Wilde ◽  
Julie A. Siegenthaler ◽  
Sharon Y.R. Dent ◽  
Lee A. Niswander
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Signaling ◽  
Acetyltransferase Activity

scholarly journals Building the muscle pattern: Role of Retinoic acid signaling in extraocular muscle morphogenesis

2017 ◽  
Vol 145 ◽  
pp. S83-S84
Author(s):  
Glenda Comai ◽  
Alexandre Robert-Moreno ◽  
Valerie Dupé ◽  
Muriel Rhinn ◽  
Norbert Ghyselinck ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Extraocular Muscle ◽  
Retinoic Acid Signaling

Induction of a RAR beta 2-lacZ transgene by retinoic acid reflects the neuromeric organization of the central nervous system

Development ◽  
1992 ◽  
Vol 116 (4) ◽  
pp. 977-983 ◽  
Author(s):  
A. Zimmer ◽  
A. Zimmer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Retinoic Acid ◽  
Retinoic Acid Receptor ◽  
Induction Pattern ◽  
The Central Nervous System ◽  
Beta 2 ◽  
Transgenic Embryos ◽  
Craniofacial Defects ◽  
Pair Rule

The hormone retinoic acid (RA) has been implicated in the organization of the anteroposterior (AP) body axis. In this paper, we describe the effects of RA on the activity of the RA-inducible retinoic acid receptor-beta 2 (RAR beta 2) promoter. When transgenic embryos carrying a RAR beta 2-lacZ reporter gene were exposed to a single dose of RA between gestational days 8.5 to 10.5, lacZ expression was induced in the anterior central nervous system (CNS). Strikingly, the transgene was expressed in a segmented pattern reminiscent of that of Drosophila ‘pair-rule’ genes. RA treatment of midgastrulation embryos at day 7.5 disturbed the segmentation and produced severe craniofacial defects. We discuss the possibility that the entire anterior CNS is segmented and that this segmentation is reflected by the RAR beta 2-lacZ induction pattern.

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