Executive function and depressed mood are independently disruptive to health-related quality of life in pediatric temporal lobe epilepsy

Objective. To investigate the effects of bright light treatment for secondary outcome measures and to explore and validate empirically derived subgroups and treatment effects in subgroups.Methods. A descriptive design. A sample of forty-nine persons (mean age of 45.8) with clinically assessed seasonal affective disorder (SAD) or subsyndromal SAD (S-SAD) participated in a two-group clinical trial evaluating the effects of treatment with bright light therapy. A person-oriented cluster analysis was applied to study treatment effects in subgroups.Results. For the merged group, sleepiness (Epworth Sleepiness Scale), fatigue (fatigue questionnaire), and health-related quality of life (SF-36) were improved at posttreatment, and results were maintained at the one-month followup. Three distinct subgroups had a high level of fatigue in common, while the level of excessive daytime sleepiness and depressed mood differed between the subgroups. Over time, all subgroups improved following ten days treatment in a light room.Conclusion. Fatigue, excessive daytime sleepiness, and health-related quality of life improve in a similar way as depressed mood following treatment with bright light. The treatment was effective irrespective of the severity of the disorder, that is, for persons with SAD and subsyndromal SAD.

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Executive function and health-related quality of life in pediatric epilepsy

Epilepsy & Behavior ◽

10.1016/j.yebeh.2016.06.006 ◽

2016 ◽

Vol 62 ◽

pp. 20-26 ◽

Cited By ~ 23

Author(s):

William A. Schraegle ◽

Jeffrey B. Titus

Keyword(s):

Quality Of Life ◽

Executive Function ◽

Pediatric Epilepsy ◽

Health Related Quality ◽

Related Quality ◽

Health Related

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Improvements in Executive Function Correlate with Enhanced Performance and Functioning and Health-Related Quality of Life: Evidence from 2 Large, Double-Blind, Randomized, Placebo-Controlled Trials in ADHD

Postgraduate Medicine ◽

10.3810/pgm.2010.09.2200 ◽

2010 ◽

Vol 122 (5) ◽

pp. 42-51 ◽

Cited By ~ 58

Author(s):

Thomas E. Brown ◽

Jeanne M. Landgraf

Keyword(s):

Quality Of Life ◽

Executive Function ◽

Controlled Trials ◽

Health Related Quality ◽

Double Blind ◽

Related Quality ◽

Health Related

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Depression and Cigarette Smoking Independently Relate to Reduced Health-Related Quality of Life among Canadians Living with Hepatitis C

Canadian Journal of Gastroenterology ◽

10.1155/2006/469761 ◽

2006 ◽

Vol 20 (2) ◽

pp. 81-86 ◽

Cited By ~ 14

Author(s):

Louise Balfour ◽

Curtis Cooper ◽

John Kowal ◽

Giorgio A Tasca ◽

Amy Silverman ◽

...

Keyword(s):

Quality Of Life ◽

Hepatitis C ◽

Cigarette Smoking ◽

Depressed Mood ◽

Health Behaviours ◽

Health Related Quality ◽

Relative Contribution ◽

Related Quality ◽

Health Related

BACKGROUND: Many people living with chronic viral hepatitis C (HCV) report reduced health-related quality of life. The relative contribution of behavioural, psychosocial and HCV disease factors to reduction in HCV health-related quality of life is not well understood. The objectives of the present study were to compare standardized health-related quality of life scores between Canadian HCV patients and age-matched Canadian and American norms, and to examine the relative contribution of biopsychosocial variables (ie, cigarette smoking, alcohol intake and depression) to health-related quality of life scores among Canadian HCV patients.METHODS: HCV RNA-positive patients were recruited during their first visit to the Ottawa Hospital Viral Hepatitis Clinic (Ottawa, Ontario). A questionnaire assessing health behaviours, health-related quality of life and depressed mood was completed. Data on liver studies, liver biopsy findings and HIV serostatus were also collected.RESULTS: A total of 123 participants (71% men) ranging from 20 to 67 years of age were evaluated. All had compensated liver function. Patients reported significantly lower health-related quality of life compared with age-matched Canadian and American normative samples. In a series of hierarchical multiple regression models, depression and smoking were independently related to compromised health-related quality of life scores, even after controlling for sociodemographic variables and health behaviours.DISCUSSION: These results highlight the value of adopting a biopsychosocial model of HCV care. Depressed mood and smoking behaviour should be evaluated in HCV patients. Empirically validated psychological and pharmacological treatments for depression and smoking cessation may improve health-related quality of life in HCV infected patients.

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