miR-218 is involved in the negative regulation of osteoclastogenesis and bone resorption by partial suppression of p38MAPK-c-Fos-NFATc1 signaling: Potential role for osteopenic diseases

2015 ◽  
Vol 338 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Bo Qu ◽  
Xun Xia ◽  
Ming Yan ◽  
Kai Gong ◽  
Shaolin Deng ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Potential Role ◽  
Negative Regulation ◽  
Partial Suppression

Potential role of NF-kB in the negative regulation of human hepatic stellate cell proliferation

1998 ◽  
Vol 28 ◽  
pp. 83
Author(s):  
C. Gallois ◽  
A. Habib ◽  
T. Jiangchuang ◽  
J. Maclouf ◽  
A. Mallat ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Hepatic Stellate Cell ◽  
Potential Role ◽  
Stellate Cell ◽  
Negative Regulation ◽  
Human Hepatic Stellate Cell

Potential Role of Hepatitis C Virus Alternate Reading Frame Protein in Negative Regulation of T-Bet Gene Expression

Inflammation ◽  
2015 ◽  
Vol 38 (5) ◽  
pp. 1823-1834 ◽  
Author(s):  
Dan Yan Zhu ◽  
Xiao Zhao Deng ◽  
Long Feng Jiang ◽  
Wen Xiao ◽  
Jia Ping Pei ◽  
...  
Keyword(s):  
Gene Expression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Potential Role ◽  
Negative Regulation ◽  
Reading Frame ◽  
Alternate Reading Frame Protein

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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