AGTR1 blocker attenuates activation of Tenon's capsule fibroblasts after glaucoma filtration surgery via the NF-κB signaling pathway

2021 ◽  
Vol 407 (1) ◽  
pp. 112786
Author(s):  
Lijun Wang ◽  
Hongsong Li ◽  
Wenyi Zhang ◽  
Meimei Ren ◽  
Meilin Shao ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Tenon’S Capsule ◽  
Tenon's Capsule

In Vitro Effect of Ascorbic Acid on the Proliferation of Bovine Scleral and Tenon's Capsule Fibroblasts

1998 ◽  
Vol 8 (1) ◽  
pp. 37-41 ◽  
Author(s):  
P.O. Denk ◽  
M. Knorr
Keyword(s):  
Wound Healing ◽  
Ascorbic Acid ◽  
Healing Process ◽  
Wound Healing Process ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Tenon’S Capsule ◽  
Tenon's Capsule ◽  
Vitro Effect

The success of glaucoma filtration surgery depends mainly on an incomplete wound healing process in the area of the fistula. Since Kornblueth and Tenenbaum's investigations in 1956 it has been known that aqueous humour has intrinsic antiproliferative properties. It is assumed that ascorbic acid is involved in the regulation of the wound healing process after filtration surgery. To evaluate the antiproliferative effect of ascorbic acid in vitro, we used cultured fibroblasts of bovine Tenon's capsule and bovine sclera. Incubation of these cells with ascorbic acid at concentrations ranging from 0.5 to 3 mM/L led to dose-dependent inhibition of cell proliferation. The half-maximal inhibitory concentration was 1.0 mM/L for both cell types. Physiological concentrations of ascorbic acid may be valuable in the pharmacological prevention of failure of glaucoma filtration surgery. However, extensive clinical investigations are needed to clarify whether topical intraoperative or postoperative as well as oral administration of ascorbic acid inhibits fibroblast proliferation after glaucoma filtration surgery.

Cysts of Tenon's Capsule Following Filtration Surgery

1982 ◽  
Vol 94 (4) ◽  
pp. 522-527 ◽  
Author(s):  
E. Michael Van Buskirk
Keyword(s):  
Filtration Surgery ◽  
Tenon’S Capsule ◽  
Tenon's Capsule

Hydroxycamptothecin Induces Apoptosis of Human Tenon's Capsule Fibroblasts by Activating the PERK Signaling Pathway

2013 ◽  
Vol 54 (7) ◽  
pp. 4749 ◽  
Author(s):  
Xue Yin ◽  
Hong Sun ◽  
Dongyi Yu ◽  
Ya Liang ◽  
Zhilan Yuan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Tenon’S Capsule ◽  
Tenon's Capsule

Comparison of phaco time parameters in eyes with and without glaucoma filtration surgery due to pseudoexfoliation glaucoma

2021 ◽  
pp. 112067212110177
Author(s):  
Ayse Gul Kocak Altintas ◽  
Cagri Ilhan
Keyword(s):  
Clinical Characteristics ◽  
Pseudoexfoliation Glaucoma ◽  
Filtration Surgery ◽  
Glaucoma Filtration Surgery ◽  
Mean Values ◽  
Time Parameters ◽  
The Mean ◽  
Group 2 ◽  
Surgical Manipulations ◽  
Phaco Time

Purpose: To compare the phaco time parameters including ultrasound time (UST), effective phaco time (EPT), and average phaco power (APP) in eyes with pseudoexfoliation glaucoma (PEG) and had or had not glaucoma filtration surgery. Methods: In this retrospective comparative study, Group 1 was constructed with 84 PEG patients who had not operated previously, and Group 2 was constructed with 49 PEG patients who had glaucoma filtration surgery. The mean values of UST, EPT, and APP were compared. The preoperative clinical characteristics and surgical manipulations were also compared. Results: The mean ages and male-to-female ratios of the groups were similar ( p > 0.05, for both). There was no difference in the preoperative clinical characteristics, including biometric values between the groups ( p > 0.05, for all). Some surgical manipulations, including pupillary stretching ( p = 0.004), pupillary membrane peeling ( p = 0.021), iris hook using ( p = 0.041), and capsular tension ring implantation ( p = 0.041), were significantly performed more commonly in Group 2. Although the mean UST and EPT values were similar ( p > 0.05, for both), the mean APP value was significantly lower in Group 2 ( p = 0.011). Conclusion: The lower APP parameter was observed in PEG patients having had glaucoma filtration surgery. Needing more surgical manipulation to overcome poor pupillary dilation and weak zonular instability can be a reason for this result.

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