Antibody-directed neutralization of annexin II (ANX II) inhibits neoangiogenesis and human breast tumor growth in a xenograft model

2012 ◽  
Vol 92 (1) ◽  
pp. 175-184 ◽  
Author(s):  
Meena Sharma ◽  
Marc R. Blackman ◽  
Mahesh C. Sharma
Keyword(s):  
Tumor Growth ◽  
Breast Tumor ◽  
Xenograft Model ◽  
Annexin Ii ◽  
Human Breast ◽  
Human Breast Tumor

Selenadiazole Derivatives Inhibit Angiogenesis-Mediated Human Breast Tumor Growth by Suppressing the VEGFR2-Mediated ERK and AKT Signaling Pathways

2018 ◽  
Vol 13 (11) ◽  
pp. 1447-1457 ◽  
Author(s):  
Haoqiang Lai ◽  
Xiaoyan Fu ◽  
Chengcheng Sang ◽  
Liyuan Hou ◽  
Pengju Feng ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Signaling Pathways ◽  
Breast Tumor ◽  
Akt Signaling ◽  
Human Breast ◽  
Human Breast Tumor

scholarly journals Paracrine Wnt signaling both promotes and inhibits human breast tumor growth

2013 ◽  
Vol 110 (17) ◽  
pp. 6991-6996 ◽  
Author(s):  
J. L. Green ◽  
J. La ◽  
K. W. Yum ◽  
P. Desai ◽  
L.-W. Rodewald ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Wnt Signaling ◽  
Breast Tumor ◽  
Human Breast ◽  
Human Breast Tumor

scholarly journals Combined MR, fluorescence and histology imaging strategy in a human breast tumor xenograft model

2012 ◽  
Vol 26 (3) ◽  
pp. 285-298 ◽  
Author(s):  
Lu Jiang ◽  
Tiffany R. Greenwood ◽  
Erika R. Amstalden van Hove ◽  
Kamila Chughtai ◽  
Venu Raman ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Xenograft Model ◽  
Tumor Xenograft ◽  
Human Breast ◽  
Human Breast Tumor ◽  
Imaging Strategy

scholarly journals Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation

2011 ◽  
Vol 208 (3) ◽  
pp. 479-490 ◽  
Author(s):  
Alexander Pedroza-Gonzalez ◽  
Kangling Xu ◽  
Te-Chia Wu ◽  
Caroline Aspord ◽  
Sasha Tindle ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Growth ◽  
Breast Tumor ◽  
Tumor Development ◽  
Thymic Stromal Lymphopoietin ◽  
Human Breast ◽  
Human Breast Tumor ◽  
Interleukin 13 ◽  
Th2 Inflammation

The human breast tumor microenvironment can display features of T helper type 2 (Th2) inflammation, and Th2 inflammation can promote tumor development. However, the molecular and cellular mechanisms contributing to Th2 inflammation in breast tumors remain unclear. Here, we show that human breast cancer cells produce thymic stromal lymphopoietin (TSLP). Breast tumor supernatants, in a TSLP-dependent manner, induce expression of OX40L on dendritic cells (DCs). OX40L+ DCs are found in primary breast tumor infiltrates. OX40L+ DCs drive development of inflammatory Th2 cells producing interleukin-13 and tumor necrosis factor in vitro. Antibodies neutralizing TSLP or OX40L inhibit breast tumor growth and interleukin-13 production in a xenograft model. Thus, breast cancer cell–derived TSLP contributes to the inflammatory Th2 microenvironment conducive to breast tumor development by inducing OX40L expression on DCs.

scholarly journals A Method to Monitor mRNA Levels in Human Breast Tumor Cells Obtained by Fine-needle Aspiration

1997 ◽  
Vol 6 (6) ◽  
pp. 353-360 ◽  
Author(s):  
Majella S. de Lange ◽  
Bert Top ◽  
Caro Lambrechts ◽  
Riks A. Maas ◽  
Hans L. Peterse ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Fine Needle Aspiration ◽  
Breast Tumor ◽  
Needle Aspiration ◽  
Mrna Levels ◽  
Human Breast ◽  
Human Breast Tumor ◽  
Breast Tumor Cells ◽  
Fine Needle
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