Suberoylanilide hydroxamic acid (SAHA) potentiates paclitaxel-induced apoptosis in ovarian cancer cell lines

2010 ◽  
Vol 116 (1) ◽  
pp. 126-130 ◽  
Author(s):  
Charles S. Dietrich ◽  
Victoria L. Greenberg ◽  
Christopher P. DeSimone ◽  
Susan C. Modesitt ◽  
John R. van Nagell ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Hydroxamic Acid ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Suberoylanilide Hydroxamic Acid ◽  
Ovarian Cancer Cell Lines ◽  
Induced Apoptosis

Suberoylanilide hydroxamic acid partly reverses resistance to paclitaxel in human ovarian cancer cell lines

2010 ◽  
Vol 119 (3) ◽  
pp. 557-563 ◽  
Author(s):  
Adriano Angelucci ◽  
Marianna Mari ◽  
Danilo Millimaggi ◽  
Ilaria Giusti ◽  
Gaspare Carta ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Hydroxamic Acid ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Human Ovarian Cancer ◽  
Suberoylanilide Hydroxamic Acid ◽  
Human Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Lines

Resistance to TRAIL-induced apoptosis in ovarian cancer cell lines is overcome by co-treatment with cytotoxic drugs

2004 ◽  
Vol 94 (1) ◽  
pp. 107-114 ◽  
Author(s):  
Sandra Tomek ◽  
Peter Horak ◽  
Ingrid Pribill ◽  
Griet Haller ◽  
Max Rössler ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Cancer Cell Lines ◽  
Cytotoxic Drugs ◽  
Ovarian Cancer Cell Lines ◽  
Induced Apoptosis

scholarly journals Downregulation of Epidermal Growth Factor Receptor Expression Contributes toα-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines

2010 ◽  
Vol 2010 ◽  
pp. 1-11 ◽  
Author(s):  
Ming-Chieh Shun ◽  
Weiping Yu ◽  
Sook-Kyung Park ◽  
Bob G. Sanders ◽  
Kimberly Kline
Keyword(s):  
Ovarian Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Growth Factor Receptor ◽  
Cell Types ◽  
Cancer Cell Lines ◽  
Ovarian Cancer Cell Lines ◽  
Induced Apoptosis ◽  
Egfr Family

RRR-α-tocopherol derivativeα-TEA (RRR-α-tocopherol ether-linked acetic acid analog) has been shown to be a potent antitumor agent both in vivo and in vitro. In this study, we investigated the effects ofα-TEA on the expression of epidermal growth factor receptor (EGFR) family members, ErbB1, 2 and 3, and the role of ErbB 2 and 3 inα-TEA-induced apoptosis and suppression of Akt, FLIP and survivin in the cisplatin-sensitive (A2780S) and -resistant (A2780/CP70R) human ovarian cancer cell lines. Data show thatα-TEA's ability to induced apoptosis was associated with reduced expression of ErbB1 (cisplatin-resistant cells), 2 and 3 (both cell types) and reduced levels of the phosphorylated (active) form of Akt; as well as, reduced levels of FLIP and survivin proteins in both cell types. Ectopic overexpression and siRNA knockdown studies showed that ErbB2, ErbB3, Akt, FLIP and survivin are involved inα-TEA-induce apoptosis and thatα-TEA downregulates FLIP and survivin via suppression of pAkt, which is mediated by ErbB2 and ErB3. Thus,α-TEA is a potent pro-apoptotic agent for both cisplatin-sensitive and -resistant ovarian cancer cell lines in cell culture and it produces cell death, at least in part, by downregulation of members of the EGFR family.

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