Long-term safety of fertility sparing surgery in early stage ovarian cancer: Comparison to standard radical surgical procedures

Purpose of the literature review: to analyze recent studies of surgical treatment of stage I-II ovarian cancer. Key issues. Individual steps of surgery and their significance, impact of the extent of surgery on the survival and adjuvant treatment, fertility-sparing surgery in young patients and safety of laparoscopic surgery are discussed. Conclusion. Optimal staging of early ovarian cancer was found to be significantly associated with overall and recurrence-free survival.

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Laparoscopic fertility-sparing surgery for early stage ovarian cancer: a single-centre case series and systematic literature review

Journal of Ovarian Research ◽

10.1186/1757-2215-7-59 ◽

2014 ◽

Vol 7 (1) ◽

pp. 59 ◽

Cited By ~ 7

Author(s):

Antonella Cromi ◽

Giorgio Bogani ◽

Stefano Uccella ◽

Jvan Casarin ◽

Maurizio Serati ◽

...

Keyword(s):

Ovarian Cancer ◽

Literature Review ◽

Systematic Literature Review ◽

Early Stage ◽

Case Series ◽

Single Centre ◽

Fertility Sparing Surgery ◽

Fertility Sparing ◽

Early Stage Ovarian Cancer

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150 The survival outcome and prognostic factors of early stage ovarian cancer, FIGO stage IA and IC, after fertility-sparing surgery (FSS): a retrospective cohort study

10.1136/ijgc-2020-igcs.130 ◽

2020 ◽

Author(s):

M Agulto-Mercadal ◽

LM Cole ◽

RA Santos

Keyword(s):

Ovarian Cancer ◽

Cohort Study ◽

Retrospective Cohort ◽

Early Stage ◽

Figo Stage ◽

Survival Outcome ◽

Fertility Sparing Surgery ◽

Fertility Sparing ◽

Stage Ia ◽

Early Stage Ovarian Cancer

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Outcomes of the First Pregnancy After Fertility-Sparing Surgery for Early-Stage Ovarian Cancer

Obstetrics and Gynecology ◽

10.1097/aog.0000000000004394 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Roni Nitecki ◽

Mark A. Clapp ◽

Shuangshuang Fu ◽

Kelly Lamiman ◽

Alexander Melamed ◽

...

Keyword(s):

Ovarian Cancer ◽

Early Stage ◽

Fertility Sparing Surgery ◽

Fertility Sparing ◽

Early Stage Ovarian Cancer

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Pregnancy following fertility-sparing surgery for early-stage ovarian cancer is not associated with poor obstetric outcomes

Gynecologic Oncology ◽

10.1016/s0090-8258(21)01112-4 ◽

2021 ◽

Vol 162 ◽

pp. S243

Author(s):

Roni Nitecki ◽

Katherine Stewart ◽

Shuangshuang Fu ◽

Terri Woodard ◽

Larissa Meyer ◽

...

Keyword(s):

Ovarian Cancer ◽

Early Stage ◽

Obstetric Outcomes ◽

Fertility Sparing Surgery ◽

Fertility Sparing ◽

Early Stage Ovarian Cancer

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Fertility preservation in women with early ovarian cancer

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2020-0026 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Daniel Necula ◽

Daria Istrate ◽

Jérôme Mathis

Keyword(s):

Ovarian Cancer ◽

Fertility Preservation ◽

Low Grade ◽

Term Survival ◽

Organizational Issues ◽

Fertility Sparing Surgery ◽

Fertility Sparing ◽

Early Ovarian Cancer ◽

Reproductive Techniques

AbstractFertility preservation is an important option to consider for young women with low-grade early ovarian cancer. Fertility-sparing surgery (“FSS”) permits the conservation of the uterus and one of the ovaries. This technique is considered safe for stages IA G1, G2 and probably safe for IC G1 epithelial and non-epithelial ovarian cancers. There are still uncertainties and FSS is not fully accepted for stage IC G1, G2 and clear cell carcinoma. The difficulty in choosing the best option lies in the fact that there is a lack of prospective randomized studies, due to ethical and organizational issues. Retrospective studies and reviews showed reassuring results for FSS in terms of relapse and long term survival. The spontaneous pregnancy rate seems to decrease after FSS, but chemotherapy does not seem to have an impact on fertility rates. Compared with the general population, assisted reproductive techniques are considered safe and with similar fertility results.

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