Comparative proteomic profiles of cervical cancer and paired paracancerous tissue and the potential effects of DUSP7 over-expression through inhibiting Ras pathway on the biological characteristics of human cervical cancer cell line

2018 ◽  
Vol 149 ◽  
pp. 48-49
Author(s):  
H. Bai ◽  
D. Teng ◽  
Z. Zhang
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Biological Characteristics ◽  
Cervical Cancer Cell Line ◽  
Ras Pathway ◽  
Over Expression ◽  
Human Cervical Cancer Cell ◽  
Human Cervical Cancer

Benzylisoquinoline alkaloids from Nelumbo nucifera Gaertn. petals with antiausterity activities against the HeLa human cervical cancer cell line

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Juthamart Maneenet ◽  
Ashraf M. Omar ◽  
Sijia Sun ◽  
Min Jo Kim ◽  
Supawadee Daodee ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Nelumbo Nucifera ◽  
Cervical Cancer Cell ◽  
Cervical Cancer Cell Line ◽  
Benzylisoquinoline Alkaloids ◽  
Human Cervical Cancer Cell ◽  
Human Cervical Cancer

Abstract Ethanolic extract of Nelumbo nucifera petals showed preferential cytotoxic activity against HeLa human cervical cancer cell line with a PC50 value of 10.4 μg/mL. This active extract was subjected to a phytochemical investigation study which led to the isolation of nine benzylisoquinoline alkaloids (1–9). The isolated compounds exhibited potent antiausterity activities. Moreover, under nutrient-deprived conditions, (−)-lirinidine (8) induced remarkable alterations in HeLa cell morphology including cell shrinkage and plasma blebbing leading to total cell death within 10 h. Mechanistically, 8 was found to inhibit Akt/mTOR signaling pathway. It also induced apoptosis by promoting caspase-3 activation and inhibiting Bcl-2 expression. Therefore, benzylisoquinoline alkaloids skeleton can be considered as a promising scaffold for the anticancer drug development against cervical cancer.

scholarly journals The restraining effect of baicalein and U0126 on human cervical cancer cell line HeLa

2017 ◽  
Vol 16 (1) ◽  
pp. 957-963 ◽  
Author(s):  
Haiqiong Ye ◽  
Yujiao Zhang ◽  
Yongzhou Wang ◽  
Jiyi Xia ◽  
Xiguang Mao ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell ◽  
Cervical Cancer Cell Line ◽  
Cell Line Hela ◽  
Human Cervical Cancer Cell ◽  
Line Hela ◽  
Human Cervical Cancer

Establishment and characterization of a human-papillomavirus negative, p53-mutation negative human cervical cancer cell line

1996 ◽  
Vol 102 (1-2) ◽  
pp. 173-181 ◽  
Author(s):  
Cheng-Yang Chou ◽  
Yen-Hui Chen ◽  
Ching-Cherng Tzeng ◽  
Yueh-Chin Cheng ◽  
Chin-Feng Chang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papillomavirus ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
P53 Mutation ◽  
Cervical Cancer Cell Line ◽  
Human Cervical Cancer Cell ◽  
Human Cervical Cancer

scholarly journals Caspase-mediated apoptotic effects of Ebenus boissieri barbey extracts on human cervical cancer cell line hela

2017 ◽  
Vol 13 (50) ◽  
pp. 254 ◽  
Author(s):  
Ece Simsek ◽  
Nilufer Imir ◽  
EsraArslan Aydemir ◽  
RamazanSuleyman Gokturk ◽  
Erdem Yesilada ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell Line ◽  
Cell Line Hela ◽  
Human Cervical Cancer Cell ◽  
Apoptotic Effects ◽  
Line Hela ◽  
Human Cervical Cancer
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