Clove (Syzygium aromaticum) Extract Potentiates Gemcitabine Cytotoxic Effect on Human Cervical Cancer Cell Line

2009 ◽  
Vol 5 (3) ◽  
pp. 95-104 ◽  
Author(s):  
A. Hussain ◽  
S. Sasidharan ◽  
T. Ahmed ◽  
M. Ahmed ◽  
C. Sharma
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell ◽  
Cervical Cancer Cell Line ◽  
Syzygium Aromaticum ◽  
Human Cervical Cancer Cell ◽  
Human Cervical Cancer

Benzylisoquinoline alkaloids from Nelumbo nucifera Gaertn. petals with antiausterity activities against the HeLa human cervical cancer cell line

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Juthamart Maneenet ◽  
Ashraf M. Omar ◽  
Sijia Sun ◽  
Min Jo Kim ◽  
Supawadee Daodee ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Nelumbo Nucifera ◽  
Cervical Cancer Cell ◽  
Cervical Cancer Cell Line ◽  
Benzylisoquinoline Alkaloids ◽  
Human Cervical Cancer Cell ◽  
Human Cervical Cancer

Abstract Ethanolic extract of Nelumbo nucifera petals showed preferential cytotoxic activity against HeLa human cervical cancer cell line with a PC50 value of 10.4 μg/mL. This active extract was subjected to a phytochemical investigation study which led to the isolation of nine benzylisoquinoline alkaloids (1–9). The isolated compounds exhibited potent antiausterity activities. Moreover, under nutrient-deprived conditions, (−)-lirinidine (8) induced remarkable alterations in HeLa cell morphology including cell shrinkage and plasma blebbing leading to total cell death within 10 h. Mechanistically, 8 was found to inhibit Akt/mTOR signaling pathway. It also induced apoptosis by promoting caspase-3 activation and inhibiting Bcl-2 expression. Therefore, benzylisoquinoline alkaloids skeleton can be considered as a promising scaffold for the anticancer drug development against cervical cancer.

scholarly journals The restraining effect of baicalein and U0126 on human cervical cancer cell line HeLa

2017 ◽  
Vol 16 (1) ◽  
pp. 957-963 ◽  
Author(s):  
Haiqiong Ye ◽  
Yujiao Zhang ◽  
Yongzhou Wang ◽  
Jiyi Xia ◽  
Xiguang Mao ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Cervical Cancer Cell ◽  
Cervical Cancer Cell Line ◽  
Cell Line Hela ◽  
Human Cervical Cancer Cell ◽  
Line Hela ◽  
Human Cervical Cancer
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