Effects of aging on testosterone and androgen receptors in the mesocorticolimbic system of male rats

2020 ◽  
Vol 120 ◽  
pp. 104689
Author(s):  
Katelyn L. Low ◽  
Ryan J. Tomm ◽  
Chunqi Ma ◽  
Daniel J. Tobiansky ◽  
Stan B. Floresco ◽  
...  
Keyword(s):  
Androgen Receptors ◽  
Male Rats ◽  
Mesocorticolimbic System ◽  
Effects Of Aging

Effects of aging on axon terminals in the dentate molecular layer

1987 ◽  
Vol 45 ◽  
pp. 928-929
Author(s):  
K. Cullen-Dockstader ◽  
E. Fifkova
Keyword(s):  
Granule Cells ◽  
Molecular Layer ◽  
Age Groups ◽  
Long Term Potentiation ◽  
Male Rats ◽  
Perforant Path ◽  
Axon Terminals ◽  
Fischer 344 ◽  
Spatial Memory Deficit ◽  
Effects Of Aging

Normal aging results in a pronounced spatial memory deficit associated with a rapid decay of long-term potentiation at the synapses between the perforant path and spines in the medial and distal thirds of the dentate molecular layer (DML), suggesting the alteration of synaptic transmission in the dentate fascia. While the number of dentate granule cells remains unchanged, and there are no obvious pathological changes in these cells associated with increasing age, the density of their axospinous contacts has been shown to decrease. There are indications that the presynaptic element is affected by senescence before the postsynaptic element, yet little attention has been given to the fine structure of the remaining axon terminals. Therefore, we studied the axon terminals of the perforant path in the DML across three age groups.5 Male rats (Fischer 344) of each age group (3, 24 and 30 months), were perfused through the aorta.

scholarly journals AGE-DEPENDENT EFFECTS OF MELATONIN ADMINISTRATION ON PROSTATIC CYTOSOL ANDROGEN RECEPTORS IN MALE RATS

1986 ◽  
Vol 20 (11) ◽  
pp. 1199-1199
Author(s):  
H Moeller ◽  
K Müller ◽  
B Goecke ◽  
A Attanasio ◽  
D Gupta
Keyword(s):  
Androgen Receptors ◽  
Male Rats ◽  
Melatonin Administration ◽  
Age Dependent

Effects of Prolactin on Prostate Androgen Receptors in Male Rats

1982 ◽  
Vol 3 (5) ◽  
pp. 281-288 ◽  
Author(s):  
JOSÉLINO S. BARAÑAO ◽  
MARTA TESONE ◽  
RICARDO M. OLIVEIRA-FILHO ◽  
VIOLETA A. CHIAUZZI ◽  
JUAN CARLOS CALVO ◽  
...  
Keyword(s):  
Androgen Receptors ◽  
Male Rats

scholarly journals Testosterone and Corticosterone in the Mesocorticolimbic System of Male Rats: Effects of Gonadectomy and Caloric Restriction

Endocrinology ◽  
2017 ◽  
Vol 159 (1) ◽  
pp. 450-464 ◽  
Author(s):  
Daniel J Tobiansky ◽  
Anastasia M Korol ◽  
Chunqi Ma ◽  
Jordan E Hamden ◽  
Cecilia Jalabert ◽  
...  
Keyword(s):  
Caloric Restriction ◽  
Male Rats ◽  
Mesocorticolimbic System

Colocalization of androgen receptors and mating-induced FOS immunoreactivity in neurons that project to the central tegmental field in male rats

1999 ◽  
Vol 408 (2) ◽  
pp. 220-236 ◽  
Author(s):  
B�atrice Gr�co ◽  
David A. Edwards ◽  
Richard P. Michael ◽  
Doris Zumpe ◽  
Andrew N. Clancy
Keyword(s):  
Androgen Receptors ◽  
Male Rats

Sex-steroid receptors in the diethylnitrosamine model of hepatocarcinogenesis: modifications by gonadal ablation and steroid replacement therapy

1989 ◽  
Vol 3 (3) ◽  
pp. 229-237 ◽  
Author(s):  
S. Tejura ◽  
G. R. Rodgers ◽  
M. H. Dunion ◽  
M. A. Parsons ◽  
J. C. E. Underwood ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Androgen Receptors ◽  
Receptor Expression ◽  
Androgen Receptor Expression ◽  
Female Rats ◽  
Male Rats ◽  
Ovariectomized Rats ◽  
Sex Steroid ◽  
Oestrogen Receptors ◽  
Liver Tumours

ABSTRACT The results of this study confirm our previous report of increased androgen receptor expression in livers of female SUAH Wistar rats during development of liver tumours induced by diethylnitrosamine (DENA). In adult female rats not treated with DENA, removal of the ovary increased liver androgen receptor levels but testosterone did not further enhance the androgen receptor status of ovariectomized rats. In normal adult males the testis and/or testosterone maintained high levels of androgen receptors but oestrogen reduced them in castrated rats. Oestrogen receptor levels were not significantly changed in either males or females by gonadectomy. Treatment of female rats with DENA for 10 and 16 weeks increased liver androgen receptors but oestrogen receptors were only reduced by 16 weeks of DENA treatment, whether the rats were intact or ovariectomized. Concentrations of liver androgen receptors were increased in intact and castrated male rats by 10 and 16 weeks of DENA treatment, an increase not seen in the previous experiments. Oestrogen appeared to inhibit both the increases in liver androgen receptor expression and liver tumour development in rats treated with the weakly carcinogenic dose of 10 weeks of DENA. However, the full carcinogenic dose of 16 weeks of DENA increased liver androgen receptors and decreased oestrogen receptors in female rats regardless of sex-steroid status. Development of malignant hepatocellular carcinoma (HCC) was associated with both an increase in liver androgen receptors and a decrease in oestrogen receptors. Maintenance of relatively high levels of liver oestrogen receptors appeared to protect the liver against development of HCC.

scholarly journals Effect of Methyltrienolone on the Metabolic Disorders in Rat Model of Alloxan-Induced Diabetes

2017 ◽  
Vol 13 (15) ◽  
pp. 22
Author(s):  
Neli Didebulidze MBiol ◽  
Sopiko Kandelaki ◽  
Manana Kakabadze ◽  
Salome Kordzaia ◽  
Dimitri Kordzaia ◽  
...  
Keyword(s):  
Rna Synthesis ◽  
Androgen Receptors ◽  
Control Level ◽  
Intraperitoneal Administration ◽  
Receptor Expression ◽  
Male Rats ◽  
Control Group ◽  
Dna And Rna ◽  
Hormonal Dysfunction ◽  
Metabolic Imbalance

Aim: The aim of the study was to investigate the restoration of metabolic imbalance related with deficiency of insulin by the exogenous androgen supplementation in the experimental model of alloxan-induced diabetes in Wistar male rats. Methods: The experimental diabetes was induced by a single intraperitoneal administration of alloxan. The concentrations of glucose, immunereactive insulin, corticosterone, testosterone and estradiol were examined in blood, the intensity of DNA and RNA synthesis and androgen receptor expression were studied in the liver tissue – at 15th, 30th and 45th days of alloxan-induced diabetes. The synthetic androgen methyltrienolone was administered to rats with 30-days diabetes during 15 days. All data were compared to control group received solvent. Results: The induction of diabetes increased the concentrations of glucose, corticosterone and estradiol while decreases insulin and testosterone concentration in blood as well as DNA/RNA synthesis and androgen receptors expression in hepatocytes. The administration of exogenous androgen significantly restored the metabolic imbalance and the expression of androgen receptors and increased DNA/RNA synthesis in liver cells maintained close to control level. Conclusion: The administration of methyltrienolone reduced the effect of “diabetic stress” and restored the hormonal dysfunction induced by alloxan.

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