AGE-DEPENDENT EFFECTS OF MELATONIN ADMINISTRATION ON PROSTATIC CYTOSOL ANDROGEN RECEPTORS IN MALE RATS

The spermatotoxic effect of carbaryl in adult and young male rats has been examined. Carbaryl 50 and 100 mg/kg b.wt. Male fed 5 d/week for 60 days, caused dose and age- dependent decline in epididymal sperm count and sperm motility, an increase in sperm with abnormal morphology. The dose of 25 mg/kg/d was a 'No observed effect level' for the indices studied. Young animals in comparison to adults exhibited pronounced spermatotoxic effects.

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Chlorpyrifos with age-dependent effects in cardiac tissue of male rats

Current Molecular Pharmacology ◽

10.2174/1874467214666210111105321 ◽

2021 ◽

Vol 14 ◽

Author(s):

Behzad Mesbahzadeh ◽

Hossein Salarjavan ◽

Saeed Samarghandian ◽

Tahereh Farkhondeh

Keyword(s):

Cardiac Tissue ◽

Organophosphorus Pesticides ◽

Male Rats ◽

Aged Rats ◽

Middle Aged ◽

Sod Activity ◽

Age Dependent ◽

Oxidative Modifications ◽

Total Antioxidant ◽

Male Wistar Rats

: Age-dependent toxic effects of organophosphorus pesticides (OPs) have not fully understood. Current study aimed to investigate the cardiotoxic damage of chlorpyrifos (CPF) by evaluating oxidative modifications in young (2-month old), middle-aged (10-month old), and aged (20-month old) rats. Five mg/kg of CPF was administered orally for 45 days to young, middle-aged, and aged male Wistar rats. At the end, animals were anesthetized and the heart of each rat was dissected for biochemical assay. Malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH), total antioxidant capacity (TAC), and superoxide dismutase (SOD) were assessed in the cardiac tissue of rats. The results indicated an increase in the levels of MDA and NO, and also a decline in the levels of GSH and TAC as well as a decrease in the SOD activity in the heart of aged rats compared with young rats. CPF administration deteriorated these changes in the heart of exposed rats compared with the age-matched controls. Additionally, these oxidative modifications were more severe in aged rats versus other age. In conclusion, advancing age may increase oxidative changes in the heart of animals exposed to CPF. It is suggested that aging can affect cardiac toxicity induced by OPs.

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The Effects of Melatonin and Serotonin on Blood Flow Fraction and Testosterone Metabolism in Selected Organs of the Male Rat

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y73-047 ◽

1973 ◽

Vol 51 (5) ◽

pp. 313-318 ◽

Cited By ~ 8

Author(s):

G. A. Kinson ◽

Nora E. MacDonald ◽

C-C. Liu

Keyword(s):

Blood Flow ◽

Nicotinamide Adenine Dinucleotide ◽

Male Rats ◽

Male Rat ◽

Blood Levels ◽

Testosterone Metabolism ◽

Melatonin Administration ◽

Distribution Of Cardiac Output ◽

Fractional Distribution

The fractional distribution of cardiac output to the testes, adrenals, liver, and kidneys and the conversion of testosterone to 4-androstenedione by hepatic and renal homogenates in vitro were measured 4 weeks after implantation of male rats with melatonin and serotonin. The fractional blood flow to these organs was not significantly influenced by the indoles. There was, however, a tendency for the adrenal fraction to be lower in indole-treated rats. Blood levels of corticosterone in these animals were reduced, but significantly so only in the rats implanted with serotonin. The ability of liver preparations to metabolize testosterone in the presence of excess nicotinamide–adenine dinucleotide was enhanced after treatment with both indoles suggesting that at least one of the 17β-hydroxysteroid dehydrogenases had been stimulated. In the case of the kidney, melatonin administration gave rise to depression of the NAD-linked conversion whereas serotonin treatment caused reductions in testosterone conversions in the presence of either NAD or NADP.

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Melatonin administration prevents cardiac and diaphragmatic mitochondrial oxidative damage in senescence-accelerated mice

Journal of Endocrinology ◽

10.1677/joe-07-0260 ◽

2007 ◽

Vol 194 (3) ◽

pp. 637-643 ◽

Cited By ~ 40

Author(s):

M I Rodriguez ◽

G Escames ◽

L C López ◽

J A García ◽

F Ortiz ◽

...

Keyword(s):

Oxidative Damage ◽

Chronic Treatment ◽

Melatonin Treatment ◽

Mitochondrial Oxidative Stress ◽

Melatonin Administration ◽

Age Dependent ◽

Mitochondrial Oxidative Damage ◽

Senescence Accelerated Mice ◽

Ratio Reduction

Cardiac and diaphragmatic mitochondria from male SAMP8 (senescent) and SAMR1 (resistant) mice of 5 or 10 months of age were studied. Levels of lipid peroxidation (LPO), glutathione (GSH), GSH disulfide (GSSG), and GSH peroxidase and GSH reductase (GRd) activities were measured. In addition, the effect of chronic treatment with the antioxidant melatonin from 1 to 10 months of age was evaluated. Cardiac and diaphragmatic mitochondria show an age-dependent increase in LPO levels and a reduction in GSH:GSSG ratios. Chronic treatment with melatonin counteracted the age-dependent LPO increase and GSH:GSSG ratio reduction in these mitochondria. Melatonin also increased GRd activity, an effect that may account for the maintenance of the mitochondrial GSH pool. Total mitochondrial content of GSH increased after melatonin treatment. In general, the effects of age and melatonin treatment were similar in senescence-resistant mice (SAMR1) and SAMP8 cardiac and diaphragmatic mitochondria, suggesting that these mice strains display similar mitochondrial oxidative damage at the age of 10 months. The results also support the efficacy of long-term melatonin treatment in preventing the age-dependent mitochondrial oxidative stress.

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