Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

2011 ◽  
Vol 50 (5) ◽  
pp. 872-883 ◽  
Author(s):  
Y.Y. Sin ◽  
H.V. Edwards ◽  
X. Li ◽  
J.P. Day ◽  
F. Christian ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Cardiac Myocytes ◽  
Hypertrophic Response ◽  
Phosphodiesterase 4 ◽  
Cyclic Amp Phosphodiesterase

scholarly journals The Biological Effects of Forsythia Leaves Containing the Cyclic AMP Phosphodiesterase 4 Inhibitor Phillyrin

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2362
Author(s):  
Sansei Nishibe ◽  
Kumiko Mitsui-Saitoh ◽  
Junichi Sakai ◽  
Takahiko Fujikawa
Keyword(s):  
Cyclic Amp ◽  
Influenza A ◽  
Biological Effects ◽  
Polyphenolic Compounds ◽  
Pde4 Inhibitor ◽  
Food Material ◽  
Common Component ◽  
Phosphodiesterase 4 ◽  
Cyclic Amp Phosphodiesterase ◽  
Forsythia Suspensa

Forsythia fruit (Forsythia suspensa Vahl (Oleaceae)) is a common component of Kampo medicines for treating the common cold, influenza, and allergies. The main polyphenolic compounds in the leaves of F. suspensa are pinoresinol β-d-glucoside, phillyrin and forsythiaside, and their levels are higher in the leaves of the plant than in the fruit. It is known that polyphenolic compounds stimulate lipid catabolism in the liver and suppress dyslipidemia, thereby attenuating diet-induced obesity and polyphenolic anti-oxidants might attenuate obesity in animals consuming high-fat diets. Recently, phillyrin was reported as a novel cyclic AMP phosphodiesterase 4 (PDE4) inhibitor derived from forsythia fruit. It was expected that the leaves of F. suspensa might display anti-obesity effects and serve as a health food material. In this review, we summarized our studies on the biological effects of forsythia leaves containing phillyrin and other polyphenolic compounds, particularly against obesity, atopic dermatitis, and influenza A virus infection, and its potential as a phytoestrogen.

scholarly journals Effects of 1-Benzylxanthines on Cyclic AMP Phosphodiesterase 4 Isoenzyme

2006 ◽  
Vol 29 (1) ◽  
pp. 131-134 ◽  
Author(s):  
Hirokazu Suzuki ◽  
Hiroyuki Sawanishi ◽  
Masaaki Nomura ◽  
Tsutomu Shimada ◽  
Ken-ichi Miyamoto
Keyword(s):  
Cyclic Amp ◽  
Phosphodiesterase 4 ◽  
Cyclic Amp Phosphodiesterase

scholarly journals Synthesis and Cyclic AMP Phosphodiesterase 4 Isoenzyme Inhibitory Activity of Heterocycle Condensed Purines

2002 ◽  
Vol 50 (9) ◽  
pp. 1163-1163 ◽  
Author(s):  
Hirokazu Suzuki ◽  
Manabu Yamamoto ◽  
Susumu Shimura ◽  
Ken-ichi Miyamoto ◽  
Kenji Yamamoto ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Inhibitory Activity ◽  
Phosphodiesterase 4 ◽  
Cyclic Amp Phosphodiesterase

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10)

2008 ◽  
Vol 20 (11) ◽  
pp. 2071-2083 ◽  
Author(s):  
Angela McCahill ◽  
Lachlan Campbell ◽  
Theresa McSorley ◽  
Arvind Sood ◽  
Martin J. Lynch ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Cardiac Myocytes ◽  
Promoter Activity ◽  
Down Regulation ◽  
Cyclic Amp Phosphodiesterase ◽  
Camp Elevation

scholarly journals Proinflammatory cytokine regulation of cyclic AMP-phosphodiesterase 4 signaling in microgliain vitroand following CNS injury

Glia ◽  
2012 ◽  
Vol 60 (12) ◽  
pp. 1839-1859 ◽  
Author(s):  
Mousumi Ghosh ◽  
Daniela Garcia-Castillo ◽  
Vladimir Aguirre ◽  
Roozbeh Golshani ◽  
Coleen M. Atkins ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Proinflammatory Cytokine ◽  
Cns Injury ◽  
Cytokine Regulation ◽  
Phosphodiesterase 4 ◽  
Cyclic Amp Phosphodiesterase

Synthesis and Cyclic AMP Phosphodiesterase 4 Isoenzyme Inhibitor Activity of Heterocycle Condensed Purines.

ChemInform ◽  
2003 ◽  
Vol 34 (10) ◽  
Author(s):  
Hirokazu Suzuki ◽  
Manabu Yamamoto ◽  
Susumu Shimura ◽  
Ken-ichi Miyamoto ◽  
Kenji Yamamoto ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Inhibitor Activity ◽  
Phosphodiesterase 4 ◽  
Cyclic Amp Phosphodiesterase

scholarly journals Targeted Inhibition of Cyclic AMP Phosphodiesterase-4 Promotes Brain Tumor Regression

2008 ◽  
Vol 14 (23) ◽  
pp. 7717-7725 ◽  
Author(s):  
Patricia Goldhoff ◽  
Nicole M. Warrington ◽  
David D. Limbrick ◽  
Andrew Hope ◽  
B. Mark Woerner ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Cyclic Amp ◽  
Tumor Regression ◽  
Phosphodiesterase 4 ◽  
Cyclic Amp Phosphodiesterase ◽  
Targeted Inhibition
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