753. Ectopic Bone Formation In Vivo Induced by Sonoporation: Ultrasound-Based Non Viral Gene Delivery System

The key strategy for the advancement of gene therapy is the development of an efficient targeted gene delivery system into cells. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relatively low transfection efficiency. It also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this study, we focused on the chemical modification of chitosan for enhancement of cell specificity and transfection efficiency. Also, the potential of clinical application was investigated.

Download Full-text

Development and characterization of an improved formulation of cholesteryl oleate-loaded cationic solid-lipid nanoparticles as an efficient non-viral gene delivery system

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2019.110533 ◽

2019 ◽

Vol 184 ◽

pp. 110533 ◽

Cited By ~ 1

Author(s):

María J. Limeres ◽

Marc Suñé-Pou ◽

Silvia Prieto-Sánchez ◽

Cristina Moreno-Castro ◽

Alejandro D. Nusblat ◽

...

Keyword(s):

Gene Delivery ◽

Delivery System ◽

Solid Lipid Nanoparticles ◽

Cholesteryl Oleate ◽

Lipid Nanoparticles ◽

Viral Gene ◽

Gene Delivery System ◽

Solid Lipid ◽

Viral Gene Delivery

Download Full-text

Novel Cationic Triblock Copolymer of Poly[2-(dimethylamino)ethyl methacrylate]-block-poly(β-amino ester)-block-poly[2-(dimethylamino)ethyl methacrylate]: A Promising Non-Viral Gene Delivery System

Macromolecular Bioscience ◽

10.1002/mabi.201400424 ◽

2014 ◽

Vol 15 (2) ◽

pp. 215-228 ◽

Cited By ~ 10

Author(s):

Rosemeyre A. Cordeiro ◽

Dina Farinha ◽

Nuno Rocha ◽

Arménio C. Serra ◽

Henrique Faneca ◽

...

Keyword(s):

Gene Delivery ◽

Delivery System ◽

Triblock Copolymer ◽

Viral Gene ◽

Amino Ester ◽

Gene Delivery System ◽

Ethyl Methacrylate ◽

Viral Gene Delivery

Download Full-text

305. Scavenging in Reactive Oxygen Species Improves Gene Expression in Polyplex Supported Gene Delivery: Nitroxyl-Radical Containing Nanoparticles Assists Non-Viral Gene Delivery System

Molecular Therapy ◽

10.1016/s1525-0016(16)36877-0 ◽

2011 ◽

Vol 19 ◽

pp. S118-S119

Keyword(s):

Gene Expression ◽

Reactive Oxygen Species ◽

Gene Delivery ◽

Delivery System ◽

Nitroxyl Radical ◽

Reactive Oxygen ◽

Viral Gene ◽

Oxygen Species ◽

Gene Delivery System ◽

Viral Gene Delivery

Download Full-text

Receptor-Mediated Gene Delivery Using Chitosan Derivatives In Vitro and In Vivo

Materials Science Forum ◽

10.4028/www.scientific.net/msf.539-543.641 ◽

2007 ◽

Vol 539-543 ◽

pp. 641-646 ◽

Cited By ~ 1

Author(s):

Tae Hee Kim ◽

Jin Hua ◽

Hyun Woo Kim ◽

Myung Haing Cho ◽

Jae Woon Nah ◽

...

Keyword(s):

Gene Delivery ◽

Delivery System ◽

Transfection Efficiency ◽

Viral Gene ◽

Gene Delivery System ◽

Targeted Gene Delivery ◽

Cell Specificity ◽

Selective Delivery

The development of an efficient targeted gene delivery system into cells is an important strategy for the advancement of gene therapy. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relative low transfection efficiency. And it also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this study, we focused on the chemical modification of chitosan for enhancement of cell specificity and transfection efficiency.

Download Full-text