Antigen-Specific Adaptive Immune Responses in Fingolimod-Treated Multiple Sclerosis Patients

2011 ◽  
Vol 2011 ◽  
pp. 121-122
Author(s):  
C.G. Mazia
Keyword(s):  
Multiple Sclerosis ◽  
Immune Responses ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Multiple Sclerosis Patients

Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients

2011 ◽  
Vol 69 (2) ◽  
pp. 408-413 ◽  
Author(s):  
Matthias Mehling ◽  
Patricia Hilbert ◽  
Stefanie Fritz ◽  
Bojana Durovic ◽  
Dominik Eichin ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune Responses ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Multiple Sclerosis Patients

scholarly journals αB-Crystallin Is a Target for Adaptive Immune Responses and a Trigger of Innate Responses in Preactive Multiple Sclerosis Lesions

2010 ◽  
Vol 69 (7) ◽  
pp. 694-703 ◽  
Author(s):  
Johannes M. van Noort ◽  
Malika Bsibsi ◽  
Wouter H. Gerritsen ◽  
Paul van der Valk ◽  
Jeffrey J. Bajramovic ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune Responses ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Αb Crystallin

scholarly journals Role of Toll-Like Receptors in Neuroimmune Diseases: Therapeutic Targets and Problems

2021 ◽  
Vol 12 ◽  
Author(s):  
Haixia Li ◽  
Shan Liu ◽  
Jinming Han ◽  
Shengxian Li ◽  
Xiaoyan Gao ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune Responses ◽  
Inflammatory Responses ◽  
Inflammatory Factors ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Toll Like Receptors ◽  
Adaptive Immune Responses ◽  
Adaptive Immune ◽  
Partial Activation

Toll-like receptors (TLRs) are a class of proteins playing a key role in innate and adaptive immune responses. TLRs are involved in the development and progression of neuroimmune diseases via initiating inflammatory responses. Thus, targeting TLRs signaling pathway may be considered as a potential therapy for neuroimmune diseases. However, the role of TLRs is elusive and complex in neuroimmune diseases. In addition to the inadequate immune response of TLRs inhibitors in the experiments, the recent studies also demonstrated that partial activation of TLRs is conducive to the production of anti-inflammatory factors and nervous system repair. Exploring the mechanism of TLRs in neuroimmune diseases and combining with developing the emerging drug may conquer neuroimmune diseases in the future. Herein, we provide an overview of the role of TLRs in several neuroimmune diseases, including multiple sclerosis, neuromyelitis optica spectrum disorder, Guillain-Barré syndrome and myasthenia gravis. Emerging difficulties and potential solutions in clinical application of TLRs inhibitors will also be discussed.

Role of the innate and adaptive immune responses in the course of multiple sclerosis

2015 ◽  
Vol 14 (4) ◽  
pp. 406-419 ◽  
Author(s):  
Bernhard Hemmer ◽  
Martin Kerschensteiner ◽  
Thomas Korn
Keyword(s):  
Multiple Sclerosis ◽  
Immune Responses ◽  
Adaptive Immune Responses ◽  
Adaptive Immune
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