scholarly journals Participant followup rate can bias structural imaging measures in longitudinal studies

2021 ◽  
Vol 1 (4) ◽  
pp. 100066
Author(s):  
Richard Beare ◽  
Gareth Ball ◽  
Joseph Yuan-Mou Yang ◽  
Chris Moran ◽  
Velandai Srikanth ◽  
...  
Author(s):  
Richard Beare ◽  
Gareth Ball ◽  
Joseph Yuan-Mou Yang ◽  
Chris Moran ◽  
Velandai Srikanth ◽  
...  

AbstractLoss of participants to followup (dropout) in longitudinal studies is inevitable and leads to great difficulty in interpretation of statistical results if dropout is correlated with a study outcome or exposure. In this article we test whether there is an additional problem that must be considered in longitudinal imaging studies, namely whether dropout has an impact on the function of FreeSurfer, a popular software pipeline used to estimate important structural brain metrics. We find that the number of acquisitions per individual does have an impact on the function of the FreeSurfer longitudinal pipelinei, and can induce group differences in brain metrics.HighlightsThis study found that group differences in the number of acquisitions involved in construction of the individual templates used in the FreeSurfer longitudinal pipeline can cause group differences in estimated cortical thickness and brain volume.


2011 ◽  
Vol 70 (1) ◽  
pp. 25-34 ◽  
Author(s):  
Ben (C) Fletcher ◽  
Jill Hanson ◽  
Nadine Page ◽  
Karen Pine

Two 3-month longitudinal studies examined weight loss following a 1-month behavioral intervention (FIT-DSD) focusing on increasing participants’ behavioral flexibility and breaking daily habits. The goal was to break the distal habits hypothesized as playing a role in unhealthy dietary and activity behaviors. The FIT-DSD intervention required participants to do something different each day and to engage in novel weekly activities to expand their behavioral repertoire. These activities were not food- or exercise-related. In Study 1, the FIT-DSD program was compared with a control condition where participants engaged in daily tasks not expected to influence behavioral flexibility. Study 2 used an active or quasicontrol group in which half the participants were also on food diets. Measures in both studies were taken pre-, post-, and post-postintervention. In Study 1, FIT-DSD participants showed greater weight loss that continued post-postintervention. In Study 2, all participants on the FIT-DSD program lost weight, weight loss continued post-postintervention, and participants who were also dieting lost no additional weight. A dose relationship was observed between increases in behavioral flexibility scores and weight loss, and this relationship was mediated by calorie intake. Corresponding reductions in BMI were also present. Increasing behavioral flexibility may be an effective approach for tackling obesity and also provides affective and potential life-skill benefits.


2018 ◽  
Vol 144 (4) ◽  
pp. 426-451 ◽  
Author(s):  
Kevin A. Hoff ◽  
Daniel A. Briley ◽  
Colin J. M. Wee ◽  
James Rounds

2018 ◽  
Vol 144 (10) ◽  
pp. 1045-1080 ◽  
Author(s):  
Ulrich Orth ◽  
Ruth Yasemin Erol ◽  
Eva C. Luciano

2008 ◽  
Author(s):  
Philip M. Sirinides ◽  
Clare Waterman ◽  
Lauren E. Angelo ◽  
Heather P. Warley ◽  
Paula A. McDermott

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