CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma

Abstract Atypical fibroxanthoma can mimic other tumors, particularly spindle cell squamous cell carcinoma and spindle cell or desmoplastic melanoma. We describe a patient with chronic lymphocytic leukemia who developed acantholytic squamous cell carcinoma on the face, which recurred and metastasized to a cervical lymph node. This tumor was at first diagnosed as atypical fibroxanthoma because of its histologic and immunostaining similarity. It showed weak or negative keratin cocktail staining and strong vimentin staining. However, a recurrent tumor was immunostained for high-molecular-weight keratin and showed strong positivity. Aggressive behavior of this squamous cell carcinoma may be due to altered immune response secondary to chronic lymphocytic leukemia.

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Utility of p63 in the differential diagnosis of atypical fibroxanthoma and spindle cell squamous cell carcinoma

Journal of Cutaneous Pathology ◽

10.1111/j.1600-0560.2008.01099.x ◽

2009 ◽

Vol 36 (5) ◽

pp. 543-547 ◽

Cited By ~ 42

Author(s):

Briana C. Gleason ◽

Kenneth B. Calder ◽

Thomas L. Cibull ◽

Antoinette B. Thomas ◽

Steven D. Billings ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Differential Diagnosis ◽

Cell Carcinoma ◽

Squamous Cell ◽

Spindle Cell ◽

Atypical Fibroxanthoma

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Unusual Presentation of Cutaneous Spindle Cell Squamous Cell Carcinoma: A Case Report

Case Reports in Dermatology ◽

10.1159/000507358 ◽

2020 ◽

Vol 12 (1) ◽

pp. 70-75

Author(s):

Erika Wernheden ◽

Hannah Trøstrup ◽

Anette Pedersen Pilt

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Node ◽

Cell Carcinoma ◽

Squamous Cell ◽

Spindle Cell ◽

Regional Lymph Node ◽

Single Cells ◽

Gluteal Region ◽

Inguinal Lymph Node Dissection ◽

Desmoplastic Melanoma

Cutaneous spindle cell squamous cell carcinoma (SpSCC) is a rare and often aggressive subtype of squamous cell carcinoma (SCC), which usually appears in sun-exposed areas, in areas that have received prior ionizing radiation, or in immunosuppressed individuals. SpSCCs are histologically characterized by keratinocytes infiltrating the dermis as single cells with elongated nuclei rather than as cohesive nests or islands and, in contrast to conventional SCC, are lacking features of keratinization. Immunohistochemical studies are useful to distinguish SpSCC from other spindle cell neoplasms, such as spindle cell/desmoplastic melanoma, cutaneous leiomyosarcoma, and atypical fibroxanthoma. We present a rare case of a patient with SpSCC in the gluteal region with regional lymph node metastasis. The patient was treated with wide excision of the tumor, inguinal lymph node dissection, and adjuvant radiotherapy. Cutaneous SpSCC is clinically similar to conventional SCC but can demonstrate more aggressive behavior. This case is rare since it was localized in the gluteal region of an otherwise healthy man.

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The role of CD10 in distinguishing atypical fibroxanthoma from sarcomatoid (spindle cell) squamous cell carcinoma

Journal of Cutaneous Pathology ◽

10.1111/j.1600-0560.2011.01768.x ◽

2011 ◽

Vol 38 (11) ◽

pp. 884-888 ◽

Cited By ~ 26

Author(s):

Carilyn N. Wieland ◽

Rayna Dyck ◽

Roger H. Weenig ◽

Nneka I. Comfere

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Spindle Cell ◽

Atypical Fibroxanthoma

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Spindle Cell Carcinoma of the Tongue: Fallacies in Its Diagnosis

International Journal of Innovative Research in Medical Science ◽

10.23958/ijirms/vol03-i02/14 ◽

2018 ◽

Vol 3 (02) ◽

Author(s):

Amrit Kaur Kaler, Shweta C, Smitha Chandra B.C, Rajeev Naik

Keyword(s):

Squamous Cell Carcinoma ◽

Oral Cavity ◽

Cell Carcinoma ◽

Cell Population ◽

Squamous Cell ◽

Spindle Cell ◽

Spindle Cell Carcinoma ◽

Biphasic Tumor ◽

Carcinoma Of The Tongue ◽

Ihc Markers

Spindle cell carcinoma is a rare aggressive biphasic tumor, composed of neoplastic proliferation of both epithelial (squamous) and spindle cell population. It constitutes about 1% of all oral cavity tumors 2a and is almost rare on the tongue; only few cases have been reported so far. This variant of squamous cell carcinoma, comprises major diagnostic problems due to its varied histomorphology and resemblance to sarcomatous lesion; hence diligent screening and IHC markers are mandatory for its diagnosis.

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