A 90-day toxicity study of GmTMT transgenic maize in Sprague-Dawley rats

This toxicological assessment evaluated the safety of a hydroethanolic extract prepared from Caralluma fimbriata (CFE), a dietary supplement marketed worldwide as an appetite suppressant. Studies included 2 in vitro genotoxicity assays, a repeated dose oral toxicity study, and a developmental study in rats. No evidence of in vitro mutagenicity or clastogenicity surfaced in the in vitro studies at concentrations up to 5000 μg of extract/plate (Ames test) or 5000 μg of extract/mL (chromosomal aberration test). No deaths or treatment-related toxicity were seen in the 6-month chronic oral toxicity study in Sprague-Dawley rats conducted at 3 doses (100, 300, and 1000 mg/kg body weight (bw)/d). The no observed effect level for CFE in this study was considered to be 1000 mg/kg bw/d. A prenatal developmental toxicity study conducted at 3 doses (250, 500, and 1000 mg/kg bw/d) in female Sprague-Dawley rats resulted in no treatment-related external, visceral, or skeletal fetal abnormalities, and no treatment-related maternal or pregnancy alterations were seen at and up to the maximum dose tested. CFE was not associated with any toxicity or adverse events.

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90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats

Food and Chemical Toxicology ◽

10.1016/j.fct.2021.112780 ◽

2021 ◽

pp. 112780

Author(s):

Shu-Chieh Hu ◽

Seonggi Min ◽

Hyun-Ki Kang ◽

Dong-Jin Yang ◽

Mallikarjuna Basavarajappa ◽

...

Keyword(s):

Toxicity Study ◽

Inhalation Toxicity ◽

Sprague Dawley ◽

Sprague Dawley Rats

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Acute Toxicity Study of Standardized Mitragyna speciosa Korth Aqueous Extract in Sprague Dawley Rats

Journal of Plant Studies ◽

10.5539/jps.v1n2p120 ◽

2012 ◽

Vol 1 (2) ◽

Cited By ~ 5

Author(s):

Mohd Saleh Ahmad Kamal ◽

Ahmad Rohi Ghazali ◽

Noral ‘Ashikin Yahya ◽

Mohd Isa Wasiman ◽

Zakiah Ismail

Keyword(s):

Acute Toxicity ◽

Aqueous Extract ◽

Toxicity Study ◽

Sprague Dawley ◽

Mitragyna Speciosa ◽

Acute Toxicity Study ◽

Sprague Dawley Rats

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4-Week repeated dose oral toxicity study of N-ethyl-2-pyrrolidone in Sprague Dawley rats

Regulatory Toxicology and Pharmacology ◽

10.1016/j.yrtph.2016.09.011 ◽

2016 ◽

Vol 81 ◽

pp. 275-283 ◽

Cited By ~ 4

Author(s):

A.M. Saillenfait ◽

F. Marquet ◽

J.P. Sabaté ◽

D. Ndiaye ◽

A.M. Lambert-Xolin

Keyword(s):

Toxicity Study ◽

Repeated Dose ◽

Sprague Dawley ◽

Oral Toxicity ◽

Sprague Dawley Rats ◽

Dose Oral

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180 Day Repeated-Dose Toxicity Study on Forchlorfenuron in Sprague–Dawley Rats and Its Effects on the Production of Steroid Hormones

Journal of Agricultural and Food Chemistry ◽

10.1021/acs.jafc.9b03855 ◽

2019 ◽

Vol 67 (36) ◽

pp. 10207-10213 ◽

Cited By ~ 3

Author(s):

Qian Bu ◽

Xiaoyan Wang ◽

Hongcheng Xie ◽

Kai Zhong ◽

Yanping Wu ◽

...

Keyword(s):

Steroid Hormones ◽

Toxicity Study ◽

Repeated Dose ◽

Sprague Dawley ◽

Sprague Dawley Rats ◽

Repeated Dose Toxicity

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Toxicity study of separase inhibitor–Sepin-1 in Sprague-Dawley rats

Pathology - Research and Practice ◽

10.1016/j.prp.2019.152730 ◽

2020 ◽

Vol 216 (1) ◽

pp. 152730

Author(s):

Nenggang Zhang ◽

Asis K. Sarkar ◽

Debananda Pati

Keyword(s):

Toxicity Study ◽

Sprague Dawley ◽

Sprague Dawley Rats

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A 4-Week Repeated Oral Dose Toxicity Study of Ssanghwa-Tang in Crl:CD Sprague Dawley Rats

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2019/2135351 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10

Author(s):

Sae-Rom Yoo ◽

Hyekyung Ha ◽

Mee-Young Lee ◽

Hyeun-kyoo Shin ◽

Su-Cheol Han ◽

...

Keyword(s):

Safety Information ◽

Experimental Period ◽

Serum Biochemistry ◽

Toxicity Study ◽

Herbal Formula ◽

Sprague Dawley ◽

Organ Weights ◽

Sprague Dawley Rats ◽

Adverse Effect Level ◽

Effect Level

Ssanghwa-tang (SHT), a traditional herbal formula, has been widely used to recover fatigue or consumptive disease after an illness. Along with much attention to herbal formula, the concerns about the safety and toxicity have arisen. To establish the safety information, SHT was administrated in Crl:CD Sprague Dawley rats at a daily dose of 0, 1000, 2000, and 5000 mg/kg for 4 weeks. During the test periods, we examined the mortality, clinical observation, body weight change, food consumption, organ weights, hematology, serum biochemistry, and urinalysis parameters. No changes of mortality and necropsy findings occurred in any of the groups during the experimental period. In either sex of rats treated with SHT at 5000 mg/kg/day, changes were observed in food intake, reticulocyte, total bilirubin, some urinalysis parameters, and relative organ weights. The results indicated that SHT did not induce toxic effects at a dose level up to 2000 mg/kg in rats. This dosage was considered no observed adverse effect level (NOAEL) and was appropriate for a 13-week subchronic toxicity study.

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