Prevention of early onset GBS sepsis: Impact of intrapartum antibiotic prophylaxis based on clinical risk factors

1997 ◽  
Vol 176 (1) ◽  
pp. S15
Author(s):  
BV Brock ◽  
DH Watts ◽  
J Sobeck ◽  
P Gill ◽  
TJ Benedetti
Keyword(s):  
Risk Factors ◽  
Antibiotic Prophylaxis ◽  
Early Onset ◽  
Clinical Risk Factors ◽  
Clinical Risk ◽  
Intrapartum Antibiotic Prophylaxis ◽  
Intrapartum Antibiotic

scholarly journals Compliance With a Protocol for Intrapartum Antibiotic Prophylaxis Against Neonatal Group B Streptococcal Sepsis in Women With Clinical Risk Factors

2002 ◽  
Vol 10 (4) ◽  
pp. 223-229 ◽  
Author(s):  
Toni R. Sanders ◽  
Christine L. Roberts ◽  
Gwendolyn L. Gilbert
Keyword(s):  
Risk Factors ◽  
Antibiotic Prophylaxis ◽  
Clinical Risk Factors ◽  
Chart Audit ◽  
Clinical Risk ◽  
Intrapartum Antibiotic Prophylaxis ◽  
Related Risk ◽  
Neonatal Group ◽  
Intrapartum Antibiotic ◽  
Group B

Objective:The aim of this study was to determine the prevalence of clinical risk factors (CRF) for neonatal sepsis in laboring women and to evaluate clinician compliance with a CRF-based protocol for intrapartum antibiotic prophylaxis (IAP).Methods:A retrospective chart audit was undertaken at a district hospital (A) and a tertiary obstetric hospital (B) in Sydney, Australia between 1996 and 1998, to determine compliance with IAP in women with defined CRF.Results:Eighty-five (12%) women at Hospital A and 117 (19%) at Hospital B had one or more CRF. Overall compliance rates with the IAP protocols were 65 and 50%at Hospitals A and B respectively, but varied according to maternal, obstetric and sepsis-related risk factors. We postulate that differences between the hospitals were related to protocol implementation.Conclusions: Compliance with a CRF-based protocol was lower than previously reported. Improvements in protocol development, implementation and maintenance are required to enhance compliance with IAP based on CRF.

scholarly journals Invazivne okužbe novorojenčkov z bakterijo Streptococcus agalactiae v Sloveniji, 2003–2013

2018 ◽  
Vol 86 (9-11) ◽  
Author(s):  
Mateja Lasič ◽  
Miha Lučovnik ◽  
Maja Pavčnik ◽  
Tina Kaparič ◽  
Miha Ciringer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Antibiotic Prophylaxis ◽  
Incidence Rate ◽  
Streptococcus Agalactiae ◽  
Early Onset ◽  
Disease Risk ◽  
Late Onset ◽  
Periventricular Leukomalacia ◽  
Intrapartum Antibiotic Prophylaxis ◽  
Intrapartum Antibiotic

Background: Streptococcus agalactiae (group B streptococcus, GBS) is the leading cause of invasive neonatal infections in the developed world. We present epidemiological and clinical characteristics of invasive GBS disease among Slovenian neonates between 2003 and 2013.Methods: A retrospective cohort study was performed. Children aged 0–90 days with invasive GBS disease, born in Slovenia and hospitalized in the University Medical Centre Ljubljana were included. Cases were identified concurrently from (i) hospital and (ii) microbiological databases. Medical records from mothers and children were reviewed and relevant data extracted. The incidence rate was calculated based on the national vital statistics data and expressed per 1000 live births.Results: Altogether, 144 children were included in the analysis, 72.9 % (n = 105) based on hospital database and 27.1 % (n = 39) based on microbiological database. Among them, 47.9 % (n = 69) were girls and 52.1 % (n = 75) boys. Among the cases with available data, 54.5 % (n = 73) were born at term and 45.5 % (n = 61) were preterm. Early-onset disease (0–6 days) was present in 74.3 % (n = 107) of patients; 95.3 % (n = 102) of them became ill during the first 3 days of life. Late-onset disease (7–90 days) was present in 25.7 % (n = 37) of patients. Outcome data was available for 134 children. Neonatal mortality rate was 4.5 % (n = 6). Periventricular leukomalacia (PVL) or intraventricular haemorrhages Grade III/IV (IVH 3/4) were detected in 17.9 % (n = 24). Severe outcomes (death or PVL or IVH 3/4) were detected in 22.4 % (n = 30) children. Cumulative incidence rate was 0.72/1000 live births; 0.53/1000 for early-onset and 0.18/1000 for late-onset disease. Risk factors for early-onset disease were present in 47.9 % (n = 68) mothers in labour. Intrapartum antibiotic prophylaxis was delivered to 16.9 % (n = 24) of mothers.Conclusions: High incidence of invasive neonatal GBS disease was detected in Slovenia. Although low mortality was observed, brain pathology concordant with long-term adverse outcome was confirmed in a high proportion of patients. The application of intrapartum antibiotic prophylaxis in cases of known risk factors was suboptimal, especially among preterm deliveries. Approximately half of the patients were born to mothers without any risk factors. A comprehensive national strategy for the prevention of invasive GBS disease is warranted in Slovenia. 

scholarly journals Intrapartum Antibiotic Prophylaxis and Early-Onset Neonatal Sepsis Patterns

2003 ◽  
Vol 11 (4) ◽  
pp. 221-226 ◽  
Author(s):  
Rodney K. Edwards ◽  
Whitney E. Jamie ◽  
Donald Sterner ◽  
Susan Gentry ◽  
Kathy Counts ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Intrapartum Antibiotic Prophylaxis ◽  
Intrapartum Antibiotic
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