Identification of HIV-1 nucleocapsid protein: nucleic acid antagonists with cellular anti-HIV activity

2002 ◽  
Vol 296 (5) ◽  
pp. 1228-1237 ◽  
Author(s):  
Andrew G Stephen ◽  
Karen M Worthy ◽  
Eric Towler ◽  
Judy A Mikovits ◽  
Shizuko Sei ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleocapsid Protein ◽  
Protein Nucleic Acid ◽  
Anti Hiv ◽  
Hiv 1

Rationally Designed Peptides as Efficient Inhibitors of Nucleic Acid Chaperone Activity of HIV-1 Nucleocapsid Protein

Biochemistry ◽  
2018 ◽  
Vol 57 (30) ◽  
pp. 4562-4573 ◽  
Author(s):  
Volodymyr Shvadchak ◽  
Sarwat Zgheib ◽  
Beata Basta ◽  
Nicolas Humbert ◽  
Johannes Langedijk ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleocapsid Protein ◽  
Chaperone Activity ◽  
Nucleic Acid Chaperone ◽  
Hiv 1

Targeting the Viral Nucleocapsid Protein in Anti-HIV-1 Therapy

2008 ◽  
Vol 8 (1) ◽  
pp. 24-35 ◽  
Author(s):  
Yves Mely ◽  
Hugues Rocquigny ◽  
Volodymyr Shvadchak ◽  
Sergiy Avilov ◽  
Chang Dong ◽  
...  
Keyword(s):  
Nucleocapsid Protein ◽  
Anti Hiv ◽  
Viral Nucleocapsid ◽  
Hiv 1

Targeting Protein-Protein and Protein-Nucleic Acid Interactions for Anti-HIV Therapy

2011 ◽  
Vol 17 (33) ◽  
pp. 3713-3728 ◽  
Author(s):  
Mattia Mori ◽  
Fabrizio Manetti ◽  
Maurizio Botta
Keyword(s):  
Nucleic Acid ◽  
Hiv Therapy ◽  
Protein Nucleic Acid ◽  
Nucleic Acid Interactions ◽  
Anti Hiv

scholarly journals Dynamics of Linker Residues Modulate the Nucleic Acid Binding Properties of the HIV-1 Nucleocapsid Protein Zinc Fingers

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e102150 ◽  
Author(s):  
Loussiné Zargarian ◽  
Carine Tisné ◽  
Pierre Barraud ◽  
Xiaoqian Xu ◽  
Nelly Morellet ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleocapsid Protein ◽  
Zinc Fingers ◽  
Nucleic Acid Binding ◽  
Binding Properties ◽  
Hiv 1

Identification by high throughput screening of small compounds inhibiting the nucleic acid destabilization activity of the HIV-1 nucleocapsid protein

Biochimie ◽  
2009 ◽  
Vol 91 (7) ◽  
pp. 916-923 ◽  
Author(s):  
Volodymyr Shvadchak ◽  
Sarah Sanglier ◽  
Sandrine Rocle ◽  
Pascal Villa ◽  
Jacques Haiech ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
High Throughput ◽  
Nucleocapsid Protein ◽  
High Throughput Screening ◽  
Hiv 1

scholarly journals Overview of the Nucleic-Acid Binding Properties of the HIV-1 Nucleocapsid Protein in Its Different Maturation States

Viruses ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 1109 ◽  
Author(s):  
Assia Mouhand ◽  
Marco Pasi ◽  
Marjorie Catala ◽  
Loussiné Zargarian ◽  
Anissa Belfetmi ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Nucleocapsid Protein ◽  
Nucleic Acid Binding ◽  
Binding Properties ◽  
Gag Polyprotein ◽  
C Terminus ◽  
Viral Particles ◽  
Hiv 1 ◽  
Unstructured Regions

HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of the nucleocapsid (NC) domain that interacts with nucleic acids, and p1 and p6, two unstructured regions, p6 containing the motifs to bind ALIX, the cellular ESCRT factor TSG101 and the viral protein Vpr. The processing of Gag by the viral protease subsequently liberates NCp15 (NC-p1-p6), NCp9 (NC-p1) and NCp7, NCp7 displaying the optimal chaperone activity of nucleic acids. This review focuses on the nucleic acid binding properties of the NC domain in the different maturation states during the HIV-1 viral cycle.

scholarly journals Fidelity of plus-strand priming requires the nucleic acid chaperone activity of HIV-1 nucleocapsid protein

2009 ◽  
Vol 37 (6) ◽  
pp. 1755-1766 ◽  
Author(s):  
Klara Post ◽  
Besik Kankia ◽  
Swathi Gopalakrishnan ◽  
Victoria Yang ◽  
Elizabeth Cramer ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleocapsid Protein ◽  
Chaperone Activity ◽  
Nucleic Acid Chaperone ◽  
Hiv 1
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