Long-term outcome of lithium prophyiaxis in bipolar disorder: A five-year prospective study

Background and objectives: Bipolar disorder (BD) is one of the most burdensome psychiatric illnesses, being associated with a negative long-term outcome and the highest suicide rate. Although affective temperaments can impact on BD long-term outcome, their role remains poorly investigated. The aims of the present study are to describe the clinical characteristics of patients with BD more frequently associated with the different affective temperaments and to assess the relation between affective temperaments and severity of clinical picture in a sample of patients with BD. Materials and Methods: A total of 199 patients have been recruited in the outpatients units of two university sites. Patients’ psychiatric symptoms, affective temperaments, and quality of life were investigated through validated assessment instruments. Results: Predominant cyclothymic and irritable temperaments are associated to higher number of relapses, poorer quality of life, higher rates of aggressive behaviors, and suicide attempts. Conversely, the predominant hyperthymic disposition was a protective factor for several outcome measures, including relapse rate, severity of anxiety, depressive and manic symptoms, suicidality, and earlier age at onset. One limitationo of the present study is that the recruitment took place in two university sites; therefore, our findings cannot be fully generalized to the whole community of BD patients. Other limitations are the lack of a control group and the cross-sectional design of the study. Conclusions: The early identification of affective temperaments can help clinicians to identify those BD patients who are more likely to show a poor long-term outcome. An early screening of affective temperaments can be useful to develop targeted integrated pharmacological and psychosocial interventions.

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Long Term Outcome of Routine Image-enhanced Endoscopy in Newly Diagnosed Head and Neck Cancer: a Prospective Study of 145 Patients

Scientific Reports ◽

10.1038/srep29573 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 3

Author(s):

Chen-Shuan Chung ◽

Wu-Chia Lo ◽

Ming-Hsun Wen ◽

Chen-Hsi Hsieh ◽

Yu-Chin Lin ◽

...

Keyword(s):

Head And Neck Cancer ◽

Prospective Study ◽

Head And Neck ◽

Neck Cancer ◽

Newly Diagnosed ◽

Term Outcome ◽

Long Term Outcome ◽

A Prospective Study

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MP-20.26: A prospective study of long-term outcome following transurethral incision of the prostate (TUIP)

Urology ◽

10.1016/j.urology.2007.06.358 ◽

2007 ◽

Vol 70 (3) ◽

pp. 159

Author(s):

D.J. Argirovic

Keyword(s):

Prospective Study ◽

Term Outcome ◽

Long Term Outcome ◽

A Prospective Study ◽

Transurethral Incision

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[79] ACUTE HEMODYNAMIC RESPONSE TO BETA-BLOCKERS FOR THE PREDICTION OF LONG-TERM OUTCOME IN PRIMARY PROPHYLAXIS OF VARICEAL BLEEDING. FINAL RESULTS OF A PROSPECTIVE STUDY

Journal of Hepatology ◽

10.1016/s0168-8278(07)61677-8 ◽

2007 ◽

Vol 46 ◽

pp. S35 ◽

Cited By ~ 6

Author(s):

C. Aracil ◽

A. Colomo ◽

I. Ordas ◽

C. Guarner ◽

X. Torras ◽

...

Keyword(s):

Prospective Study ◽

Variceal Bleeding ◽

Beta Blockers ◽

Primary Prophylaxis ◽

Hemodynamic Response ◽

Term Outcome ◽

Long Term Outcome ◽

A Prospective Study

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Long-term outcome of anterior cruciate ligament tear without reconstruction: a longitudinal prospective study

International Orthopaedics ◽

10.1007/s00264-016-3294-0 ◽

2016 ◽

Vol 40 (11) ◽

pp. 2325-2330 ◽

Cited By ~ 3

Author(s):

Christian Konrads ◽

Stephan Reppenhagen ◽

Daniel Belder ◽

Sascha Goebel ◽

Maximilian Rudert ◽

...

Keyword(s):

Anterior Cruciate Ligament ◽

Prospective Study ◽

Cruciate Ligament ◽

Anterior Cruciate Ligament Tear ◽

Term Outcome ◽

Long Term Outcome ◽

Ligament Tear ◽

Anterior Cruciate

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PS01.005: HIGH-RESOLUTION MANOMETRY GUIDING SURGICAL PROCEDURE FOR TREATMENT OF ACHALASIA OF THE ESOPHAGUS. LONG-TERM RESULTS OF A PROSPECTIVE STUDY

Diseases of the Esophagus ◽

10.1093/dote/doy089.ps01.005 ◽

2018 ◽

Vol 31 (Supplement_1) ◽

pp. 51-51

Author(s):

Tania Triantafyllou ◽

Georgia Doulami ◽

Charalampos Theodoropoulos ◽

Georgios Zografos ◽

Dimitrios Theodorou

Keyword(s):

High Resolution ◽

Prospective Study ◽

Conflicts Of Interest ◽

Long Term Results ◽

Type I ◽

Laparoscopic Myotomy ◽

Term Outcome ◽

Long Term Outcome ◽

High Resolution Manometry

Abstract Background Laparoscopic myotomy and fundoplication for the treatment of achalasia presents with 90% success rate. The intraoperative use of manometry during surgery has been previously introduced to improve the outcome. Recently, we presented our pilot study proposing the use of the HRM during surgery. The aim of this study is to evaluate the long-term outcome of the intraoperative use of High-Resolution Manometry (HRM) in achalasia patients. Methods In this prospective study, consecutive achalasia patients underwent laparoscopic myotomy and fundoplication along with real-time use of HRM. Eckardt scores (ES) and HRM results were collected before and after surgery. Results Twenty-three achalasia patients (22% Type I, 57% Type II, 22% Type III, according to Chicago Classification v3.0) with a mean age 48 years underwent calibrated and uneventful myotomy and fundoplication. Eleven myotomies were further extended, while sixteen fundoplications were intraoperatively modified, according to manometric findings. During postoperative follow-up, mean resting and residual pressures of the LES were significantly decreased after surgery (16,1 vs. 41,9, P = 0 and 9 vs. 28,7, P = 0, respectively). The ES was also diminished (1 vs. 7, P = 0). Conclusion The intraoperative use of HRM during laparoscopic myotomy and fundoplication for the treatment of achalasia of the esophagus is a safe, promising and efficient approach aiming to individualize both myotomy and fundoplication for each achalasia patient. Disclosure All authors have declared no conflicts of interest.

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